Navigation Links
Hepatitis C treatment's side effects can now be studied in the lab
Date:11/16/2012

The adverse side effects of certain hepatitis C medications can now be replicated and observed in Petri dishes and test tubes, thanks to a research team led by Craig Cameron, the Paul Berg Professor of Biochemistry and Molecular Biology at Penn State University. "The new method not only will help us to understand the recent failures of hepatitis C antiviral drugs in some patients in clinical trials," said Cameron. "It also could help to identify medications that eliminate all adverse effects." The team's findings, published in the current issue of the journal PLOS Pathogens may help pave the way toward the development of safer and more-effective treatments for hepatitis C, as well as other pathogens such as SARS and West Nile virus.

First author Jamie Arnold, a research associate in Cameron's lab at Penn State, explained that the hepatitis C virus (HCV), which affects over 170,000,000 people worldwide, is the leading cause of liver disease and, although antiviral treatments are effective in many patients, they cause serious side effects in others. "Many antiviral medications for treating HCV are chemical analogs for the building blocks of RNA that are used to assemble new copies of the virus's genome, enabling it to replicate," he said. "These medications are close enough to the virus's natural building blocks that they get incorporated into the virus's genome. But they also are different in ways that lead to the virus's incomplete replication. The problem, however, is that the medication not only mimics the virus's genetic material, but also the genetic material of the patient. So, while the drug causes damage to the virus, it also may affect the patient's own healthy tissues."

A method to reveal these adverse side effects in the safety of a laboratory setting, rather than in clinical trials where patients may be placed at risk, has been developed by the research team, which includes Cameron; Arnold; Suresh Sharma, a research associate
'/>"/>

Contact: Barbara K. Kennedy
science@psu.edu
814-863-4682
Penn State
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Antiviral Therapy May Cut Recurrence of Hepatitis B-Linked Liver Cancer
2. Earlier treatment for young patients with chronic hepatitis B more effective in clearing virus
3. Telaprevir: Added benefit in certain patients with hepatitis C
4. Test All Baby Boomers for Hepatitis C: CDC
5. Annals of Internal Medicine publishes new CDC recommendations on hepatitis C screening
6. Hepatitis A Vaccine for Children Lasts for 10 Years: Study
7. Hepatitis C Treatment May Hamper Kids Growth
8. Hepatitis A vaccination in children under 2 remains effective for 10 years
9. World Hepatitis Day - EASL calls on the United Nations to join the effort to tackle viral hepatitis
10. Smoking Tied to Risk for Hepatitis Return After Liver Transplant
11. NIH scientists identify likely predictors of hepatitis C severity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hepatitis C treatment's side effects can now be studied in the lab
(Date:8/1/2015)... ... 01, 2015 , ... On March 19, 2015 Phil Valentine – the Executive Director of Connecticut ... Trail by stepping off Springer Mountain and heading north. Since that day, Phil has ... Connecticut and was greeted by friends and family. He visited CCAR and left an ...
(Date:7/31/2015)... ... July 31, 2015 , ... When the weather turned hot and warm-season ... type of sod called Leisure Time(TM) zoysia . It's nicknamed LTZ(TM) for short. ... introduction of this new type of sod, Super-Sod is giving away red Adirondack chairs ...
(Date:7/31/2015)... ... ... Ticket Down is a reliable source for authentic tickets for the 2015 ... festival will end on Sunday, August 2nd. , Music fans have traveled ... unique and unbelievably popular festival attracts the best in entertainment from around the world. ...
(Date:7/31/2015)... ... July 31, 2015 , ... Last week, ... GoodThreads. The store can be accessed by visiting http://www.curemeso.org/store . , “Our ... customizable. The best part: whenever a product is purchased, the Meso Foundation receives ...
(Date:7/31/2015)... ... July 31, 2015 , ... There’s no better way to enjoy ... comes time to cook the next meal, making July the most appropriate to be ... grilling tips and recipes. , Make the next cookout different than the ones in ...
Breaking Medicine News(10 mins):Health News:Connecticut Executive Hikes Appalachian Trail to Raise Awareness About Recovery. 2Health News:Super-Sod Introduces Leisure Time(TM) Zoysia Grass with an Adirondack Chair Promotion 2Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3
... 12 Repligen Corporation (Nasdaq: RGEN ), ... A products, announced today that the Company has received ... practices for manufacturing and quality systems. ISO certification ... manufacture of products and related services underlying its Protein ...
... and CEO, Scott Grisanti, Publishes Letter Outlining Strategy, ... 12 MedClean Technologies, Inc. (OTC Bulletin Board: ... for the onsite treatment and disposal of regulated ... CEO, Scott Grisanti, has published a letter to ...
... Inc., a premier,technology consulting firm, and Studio Velo, an ... the launch of a new bike club dedicated,to the ... good cause,the American Brain Tumor Association (ABTA). , ... The Studio Velo/Kovarus Cycling Club ...
... Health Integrated, the leading Targeted Population Health ... Analytics company, are partnering to jointly offer health ... targeted population management with advanced business intelligence. Mede,s ... and accurately informed about areas of particular concern ...
... and Ear Infirmary Joins International Observance To Draw Attention To ... In an effort to combat one of ... and the World Glaucoma Patient Organization have set March 12, ... The day will be marked by awareness and educational events ...
... Historic Perspective and Future DirectionsRALEIGH, N.C., Feb. 12 ... leading Clinical Research Organization, will host a prominent panel ... on February 25. Discussions will include case scenarios on ... are applicable to other fields of infectious disease research.The ...
Cached Medicine News:Health News:Repligen Announces ISO 9001:2000 Certification 2Health News:Repligen Announces ISO 9001:2000 Certification 3Health News:MedClean Technologies Inc. CEO Publishes Letter to Shareholders 2Health News:Biking for Fun, Sport, and Brain Tumor Awareness 2Health News:Biking for Fun, Sport, and Brain Tumor Awareness 3Health News:MedeFinance and Health Integrated Partner to Give Health Plans Competitive Advantage 2Health News:MedeFinance and Health Integrated Partner to Give Health Plans Competitive Advantage 3Health News:World Glaucoma Day Set For March 12, 2009 2Health News:World Glaucoma Day Set For March 12, 2009 3Health News:World Glaucoma Day Set For March 12, 2009 4Health News:PRA International Speaking Event: Rational Drug Design and Development in Infectious Diseases 2
(Date:7/30/2015)... 2015  Cleveland Clinic President Wael Barsoum , ... month that industry is compelled to adopt declining reimbursements ... efficiencies—and develop the transformational innovations -- required to thrive ... preceded by Doug Kohrs , past President and ... stressed that industry must add "episode of care," also ...
(Date:7/30/2015)... July 30, 2015 Future Market ... titled, "Continuous Glucose Monitoring Systems Market: Global Industry Analysis ... report, the global continuous glucose monitoring systems market was ... expected to reach US$ 788.4 Mn by 2020, registering ... to 2020. Global continuous glucose monitoring systems ...
(Date:7/30/2015)... , July 30, 2015 Takeda Pharmaceutical ... study to fulfill the post-marketing commitment and submissions ... Pan European Multi-Database Bladder Cancer Risk Characterization Study ... cohort study, conducted in four European countries, for ... up to 10 years of follow-up. Findings demonstrate ...
Breaking Medicine Technology:Orthopaedic Surgery Reimbursement Shifts to Episode of Care 2Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 2Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 3Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 4Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 2Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 3Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 4Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 5Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 6
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: