Navigation Links
Hepatitis B virus reemerges with long-term nucleoside analog treatment
Date:4/27/2011

A recently published study revealed that virological breakthrough (VBT) is common in patients receiving nucleoside analogs (NUCs) for chronic hepatitis B. Nearly 40% of the VBTs found were not related to antiviral drug resistance. Details of this retrospective study are published in the May issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases.

VBT is the first manifestation of antiviral drug resistance during NUC therapy of chronic hepatitis B. NUC drugs approved for treatment of chronic hepatitis B include lamivudine (LAM), adefovir (ADV), entecavir (ETV), telbivudine (TBV), and tenofovir (TDF). While the medications suppress the virus with few side effects, they do not eradicate HBV and require long-term treatment to provide clinical benefit. With long-term NUC therapy, studies have shown an increasing risk of drug resistance particularly with monotherapy regimens.

In the current study, Anna Lok, M.D. and colleagues from the University of Michigan Health System examined the incidence of VBT and genotypic resistance (GR) in 148 patients with chronic hepatitis B who were treated with NUCs between January 2000 and July 2010. The mean age of study participants was 45 years and 73% were male. Researchers reviewed medical records and recorded patient demographics, hepatitis B virus (HBV) markers, liver panel, blood counts and liver histology.

Results showed that during a mean follow-up of 38 months, 39 (26%) patients had at least one VBT, and upon retesting, 15 (38%) of these patients did not have a VBT and 10 had no evidence of GR. Researchers reported the probability of VBT, confirmed VBT, and GR at five years was 46%, 30%, and 34%, respectively. "Our analysis showed an alarmingly high rate of VBT in clinical practice and the only factor significantly linked to VBT was failure to achieve undectectable HBV DNA," said Dr. Lok.

HBV DNA decreased
'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New screening system for hepatitis C
2. Groundbreaking research to find vaccine for hepatitis C
3. 1 in 5 At-Risk U.S. Babies Doesnt Get Hepatitis B Vaccine
4. Vaccination, Prevention Is Beating Back Hepatitis
5. Bipartisan Capitol Hill Media Event: Health Experts, Lawmakers to Urge Federal Government to Fix the Funding Failure for Chronic Viral Hepatitis
6. Hepatitis C treatment less effective in urban minority patients
7. Researchers identify potential new target for treating hepatitis C
8. Donor kidneys from Hepatitis C patients needlessly denied to patients with that infection
9. Henry Ford Hospital atudy: Hepatitis C infection doubles risk for kidney cancer
10. New Drug Shows Promise for Curing Hepatitis C
11. Hepatitis C Tied to Higher Kidney Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... small protein beta-amyloid is strongly associated with Alzheimer,s disease; ... this peptide is the causal agent of the onset ... such confirmation is that beta-amyloid is not harmful when ... is when it self-assembles to form the so-called amyloid ... target, beta-amyloid alone, but with multiple ones because each ...
(Date:10/1/2014)... research co-funded by the Engineering and Physical Sciences ... of the UK,s vital industrial control systems which ... electricity grid, and the rail network. , ... from hackers or malware infiltrating the systems behind ... Institute in Trustworthy Industrial Control Systems (RITICS), based ...
(Date:10/1/2014)... Familylifeinsurancequotes.org has released a new blog post explaining ... , Senior citizens can qualify for affordable term life ... who are over 50 years old. Some term life ... examination. , Term life insurance with a simplified issue ... Having life insurance during retirement is important for covering ...
(Date:10/1/2014)... Lifeinsurance-policy.com has released a new blog post ... for smokers. , Smoking will always have a negative ... the best method to find affordable coverage. Insurance brokerage ... coverage. , Whole life insurance premiums will be ... the coverage is permanent, the initial rates are ...
(Date:10/1/2014)... FARMINGTON, Conn. (PRWEB) October 01, 2014 ... its company, including a redefined mission and visual ... the power of partnering with them to create ... more agile brand that focuses on empowering customers ... benefits communications. , The crown jewel of the ...
Breaking Medicine News(10 mins):Health News:Laying siege to beta-amyloid, the key protein in Alzheimer's disease 2Health News:£2.5 million to recognize and reduce cyber-attack threats to critical infrastructure 2Health News:Affordable Term Life Insurance - Senior Citizens Can Qualify for Coverage! 2Health News:Affordable Whole Life Insurance Premiums for Smokers! 2Health News:Farmington Company Launches Rebrand and New Positioning 2
... SAN DIEGO, March 11 NuVasive, Inc. (Nasdaq: ... developing products for minimally disruptive surgical treatments for the ... is scheduled to present at the Cowen & Company ... Place in Boston, Massachusetts on Wednesday, March 18, 2009, ...
... disability, quality of life similar on levodopa or pramipexole, ... Two drugs -- levodopa and pramipexole -- used to ... disadvantages, but their overall impact appears to even out ... conclusion of a new study that included hundreds of ...
... In the end the objective was clear: a European Research ... findings and technology would be as natural as the free ... the year 2020. , Although there is still a long ... start has been made in many areas. This was apparent ...
... Karp and Ron Fink Open Their Door at CareMinders Home ... Need of Their Services.WEST BLOOMFIELD, Mich., March 11 It,s ... Fink turned the lights on in their West Bloomfield offices ... impact in the community.While very few startup companies have been ...
... the congress of the European Association of Cardiovascular Prevention ... a five-year period of heart-healthy political activity in Europe ... the European Heart Health Charter to the European Parliament. ... joint organiser Professor Joep Perk. "Now is the time ...
... French . , Montreal, March 11, 2009 Thrill-seeking ... of cannabis (DUIC) and engage in reckless driving, according to ... journal Accident Analysis and Prevention , men who are ... taking the wheel after consuming cannabis more often than older ...
Cached Medicine News:Health News:NuVasive to Present at Cowen and Company 29th Annual Healthcare Conference 2Health News:Parkinson's Treatment Drugs Even Out Over Long Term 2Health News:Science as a pioneer 2Health News:Science as a pioneer 3Health News:There is No Place Like CareMinders Home Care and the Dedication and Commitment of the Owners 2Health News:EuroPRevent 09: Changing hearts and minds in the drive to prevent cardiovascular disease 2Health News:EuroPRevent 09: Changing hearts and minds in the drive to prevent cardiovascular disease 3Health News:Study finds cannabis use, dangerous driving behaviors interrelated 2
(Date:10/1/2014)... Oct. 1, 2014  Express Scripts (NASDAQ: ... 2015 Express Scripts Medicare ® Prescription Drug Plans ... Walgreens (NYSE: WAG ) (NASDAQ: ... and clinical support  for their Medicare dollars. ... Value or Choice plans for ...
(Date:10/1/2014)... 1, 2014 Ardelyx, Inc. (NASDAQ: ... company focused on cardio-renal, gastrointestinal and metabolic ... 371 patient Phase 2b clinical trial evaluating ... syndrome (IBS-C).  Results from this study demonstrated ... IBS-C symptoms for tenapanor-treated patients compared to ...
(Date:9/30/2014)... , Sept. 30, 2014 /CNW/ - Protecting the health and safety ... Health Canada uses the appropriate powers and tools at its disposal ... safety and quality standards. To that end, Health ... stop the import into Canada of all ... . They are: , Apotex Pharmachem India Pvt ...
Breaking Medicine Technology:Express Scripts Collaborates with Walgreens to Create Value-Driven Medicare Prescription Drug Plan Pharmacy Network 2Express Scripts Collaborates with Walgreens to Create Value-Driven Medicare Prescription Drug Plan Pharmacy Network 3Express Scripts Collaborates with Walgreens to Create Value-Driven Medicare Prescription Drug Plan Pharmacy Network 4Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 2Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 3Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 4Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 5Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 6Statement by the Honourable Rona Ambrose on the import ban of drug products from three plants in India 2
... Pacific Bridge Medical will be attending the Medical ... 28-30, 2010, at the Donald E. Stephens Convention ... is part of a national conference series for ... affairs within the pharmaceutical and medical device manufacturing ...
... 23 BioMarin Pharmaceutical Inc. (Nasdaq: BMRN ) ... M. Bate to its Board of Directors. "We ... to our Board of Directors.  With experience, vision and proven ... to take on this important role in the company," said ...
Cached Medicine Technology:Asian Medical Markets Expert to Attend the MD&M Midwest Conference 2BioMarin Appoints William Young and Kenneth Bate to Its Board of Directors 2BioMarin Appoints William Young and Kenneth Bate to Its Board of Directors 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: