Navigation Links
Hepatic injury in cholelithiasis and cholecystitis
Date:8/25/2009

Acute hepatocellular injury is a commonly encountered phenomenon in patients with cholelithiasis and concomitant common bile duct (CBD) stones. However, in clinical practice, it seemed to occur also in cholelithiasis patients without evidence of CBD stones. Its incidence and final outcome necessitated clarification.

A research article to be published on August 14, 2009 in the World Journal of Gastroenterology addresses this question. The research team, led by Dr. Shou-Chuan Shih from Mackay Memorial Hospital (Taiwan, China) investigated acute transient hepatocellular injury in patients with cholelithiasis and cholecystitis but no evidence of choledocholithiasis.

The medical records of patients with cholelithiasis who underwent cholecystectomy between July 2003 and June 2007 were retrospectively reviewed. Imaging studies to detect CBD stones were performed in 186 patients, who constituted the study population. Biochemical liver tests before and after surgery, and with the presence or absence of CBD stones were analyzed.

They found that, in 96 patients with cholelithiasis and cholecystitis without evidence of CBD stones, 49 (51.0%) had an alanine aminotransferase level elevated to 2-3 times the upper limit of normal, and 40 (41.2%) had an elevated aspartate aminotransferase level. Similar manifestations of hepatocellular injury were, as would be expected, even more obvious in the 90 patients with CBD stones. These markers of hepatocellular injury resolved almost completely within 2 week to 1 moth after cholecystectomy. Compared to 59 patients with histologically less severe cholecystitis.

The result indicated that acute hepatocel lular injury in cholelithiasis and cholecystitis without choledocholithiasis is mild and transient . Hyperbilirubinemia and leukocytosis may predict severe inflammatory changes in the gallbladder.


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. A potential therapeutic agent for hepatic fibrosis
2. Are imaging features of hepatic angiomyolipoma related to its clinical setting?
3. Large congenital and solitary intrahepatic arterioportal
4. Cathepsin B increases apoptosis in fulminant hepatic failure
5. May hepatic granulomas be part of the histological spectrum of chronic hepatitis C?
6. Stem cells from umbilical cord used in the treatment of hepatic diseases
7. Hyperion Therapeutics Announces Enrollment of First Patient in Phase 2 Clinical Trial in Patients With Hepatic Encephalopathy
8. Attention: Extra-hepatic manifestation of hepatitis C virus infection
9. Strong link found between concussions and brain tissue injury
10. A Miracle Man's 30-Foot Fall Leave New York Personal Injury Attorneys Believing in Miracles, too
11. Brain and Spinal Injury Trust Fund Commission Annual Meeting and Award Ceremony
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... 2016 , ... Healing Cancer in This Century is a Summit ... recovery and is offered by creator and visionary Carlos Caridad. Healing Cancer In ... considering medical and healing modalities of the fields of Integrative, Alternative, Energetic, Holistic ...
(Date:5/3/2016)... ... ... Calvary Hospital recently hosted a reception to mark a new music program ... Mary, Manning Walsh Home (MMW) in Manhattan. , During the school year, a ... once a week. The music brings a lot of joy to the patients, family ...
(Date:5/3/2016)... (PRWEB) , ... May 03, 2016 , ... ... a process that selects DNA or RNA from a random library of sequences ... be used as drugs or diagnostic agents. SELEX selection is commonly performed using ...
(Date:5/3/2016)... ... May 03, 2016 , ... Cosmetic surgeon Dr. Mark Youssef ... 2014, incorporating the injectable filler into his menu of services to give his patients ... than a year later, he’s still improving his approach to ensure he stays at ...
(Date:5/3/2016)... WORTH, Texas (PRWEB) , ... May 03, 2016 , ... ... of the signs of pet anxiety. "Pet owners often think anxiety only manifests ... sending stress signals in other ways, and there’s things that be done about it,” ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... , April 29, 2016 ... Life Sciences, Product Development Capabilities in ... Customer Base . Indegene ( ... announced the acquisition of Skura Corporation,s life science ... in adaptive sales enablement technology for life science ...
(Date:4/28/2016)... 28, 2016   Click here for supplemental ... (NYSE: DPLO), the nation,s largest independent specialty pharmacy, ... agreement to acquire Valley Campus Pharmacy, Inc., doing ... leading specialty pharmacy that provides individualized patient care, ... . In 2015, TNH generated approximately $400 million ...
(Date:4/28/2016)... Dr. ... und Stephen Schmidt werden Teil ... ein führender Anbieter cloudbasierter Softwarelösungen für den ... neue Führungskräfte zum Team Sicherheit und Pharmakovigilanz ... Erfahrungen mitbringen.  Dies wird die Geschäftseinheit Sicherheit ...
Breaking Medicine Technology: