Navigation Links
Hemostatic drug less effective than originally predicted
Date:11/15/2010

The use of recombinant activated factor 7 (rFVIIa) a drug used to treat bleeding in hemophiliacs in patients without hemophilia is not recommended because of the potential for adverse events, found a study published in CMAJ (Canadian Medical Association Journal) (pre-embargo link only) http://www.cmaj.ca/embargo/cmaj100408.pdf.

Recombinant activated factor 7 is a hemostatic agent licensed for the treatment of bleeding in hemophilia patients. It is also used "off-label" for the prevention and treatment of bleeding in patients without hemophilia including patients undergoing surgery, liver transplants and other procedures.

The use of rFVIIa in people without hemophilia appears to be common. For example, out of more than 2700 cases in the Australian and New Zealand Hemostasis Registry that use rFVIIa, only 1% had a diagnosis of hemophilia.

This systematic review was conducted to analyze the effectiveness and risks of rFVIIa in patients without hemophilia and to assess the implications of these results for future research.

"Physicians must believe that 'off-label' use is effective and outweighs risks," write Dr. Yulia Lin, Sunnybrook Health Sciences Centre and coauthors. "However, randomized controlled trials (RCTs) evaluating rFVIIa have raised concerns about adverse effects, particularly thromboembolic events (blood clots)."

The review, which looked at 14 prophylactic use RCTs including 1137 patients and 12 therapeutic use RCTs with 2538 patients, found uncertainty about the benefits and harms of this therapy.

"Clinically significant benefits of rFVIIa as a more general hemostatic drug (outside of hemophilia) remain unproven," conclude the authors. "This systematic review has not shown a consistent benefit of off-label rFVIIa use in the therapeutic setting and (at best) only modest benefits in the prophylactic setting. Given the potential risks, it cannot be recommended and in most cases, its use should
'/>"/>

Contact: Kim Barnhardt
kim.barnhardt@cmaj.ca
613-520-7116 x2224
Canadian Medical Association Journal
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Hemostatic powder stops bleeding ulcers: Doctor
2. New Malaria Drug Proves Effective in Study of African Children
3. 5-year results show keyhole bowel cancer surgery is safe and effective
4. New lymphoma therapy may be more effective with fewer side effects
5. Diverse surgeons initiative effectively increases underrepresented minorities in academic surgery
6. Gene Mutations May Blunt Plavixs Effectiveness, Study Finds
7. Newer, more intense chemotherapy with less radiation not more effective against Hodgkins lymphoma
8. Parent-only treatment may be equally effective for children who are obese
9. Home Monitoring of Blood-Thinner Use Appears Effective
10. Conventional, annual Pap smear cost-effective follow-up after cervical lesion treatment
11. Proton therapy safe, effective for early-stage lung cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... Adults 65 and older who ... coverage during the current open enrollment period can ... step-by-step guidance, the company announced today. , The ... the correct Medicare Advantage plan, understanding the differences ... , “With just one month remaining of open ...
(Date:10/31/2014)... News) -- Carving pumpkins and trick-or-treating may seem like ... emergency rooms in the United States every year, experts ... fifth highest number of ER visits involving children aged ... the National Electronic Injury Surveillance System. Nearly ... the American Academy of Orthopaedic Surgeons and the Pediatric ...
(Date:10/31/2014)... Dennis Thompson ... News) -- A full-court press involving all public health ... to quell the current West African epidemic, a new ... the Ebola-infected dead in a hygienic way, immediately isolating ... and providing better protection for health care workers -- ...
(Date:10/31/2014)... Institutes of Health will facilitate communication among scientists, ... research, from diagnosis to treatment. The Research Domain ... National Institute of Mental Health (NIMH), part of ... RDoC initiative. , The aim of the ... research that translates basic science into clinical settings ...
(Date:10/31/2014)... (HealthDay News) -- There are clear differences in the ... brains of healthy people, new research indicates. ... findings could help doctors diagnose this baffling condition and ... fatigue syndrome are often misdiagnosed or labeled as hypochondriacs. ... "we found that [chronic fatigue syndrome] patients, brains ...
Breaking Medicine News(10 mins):Health News:Halloween at the ER Is No Treat 2Health News:4 Steps Could Quell Ebola in West Africa, Researchers Say 2Health News:4 Steps Could Quell Ebola in West Africa, Researchers Say 3Health News:NIMH creates new unit to support its research domain criteria initiative 2Health News:Brain Scans Yield Clues to Chronic Fatigue Syndrome 2Health News:Brain Scans Yield Clues to Chronic Fatigue Syndrome 3
... and Author Honored for Worldwide Contribution to Medicine , ... is pleased to announce that world-renown laparoscopic surgeon Constantine Frantzides, ... has been selected as one of America,s Top Doctors ... the ninth annual Castle Connolly acclaimed guide to the top ...
... , , , , ... WESTPORT, Conn. , Jan. 23 Save the Children and ... affected by the earthquake. Westport -based Save the Children,s emergency response ... medical supplies in the town of Leogane and at the general hospital ...
... While genes matter, teacher/parent input is key, researchers find ... an important role in the growth of young children,s ... have to take more seriously genetic influences on learning, ... skills can make strides with proper instruction," lead author ...
... Experts find physical and mental benefits as people grow old ... military campaigns and gunning down bad guys might not sound ... or exercise. , But they might want to start, some ... video games have the potential to help seniors age more ...
... at St. Joseph,s Hospital and Medical Center have been awarded ... (NIH) to research the effects of nicotine and develop new ... research projects at the Phoenix-based institute in the next several ... Research at Barrow, is one of the world,s leading experts ...
... the medical university Karolinska Institutet have created a genetically ... by blue light. Shining blue light on brainstems or ... activity. The findings, which are published in the scientific ... to the recovery of walking after spinal cord injury. ...
Cached Medicine News:Health News:Dr. Constantine Frantzides Named One of America's Top Doctors 2Health News:Save the Children Partners with AmeriCares to Treat More than 85,000 Haitians 2Health News:Save the Children Partners with AmeriCares to Treat More than 85,000 Haitians 3Health News:Save the Children Partners with AmeriCares to Treat More than 85,000 Haitians 4Health News:Environment Crucial to Boosting Child's Reading Skills 2Health News:Video Gaming Just Might Fight Aging 2Health News:Video Gaming Just Might Fight Aging 3Health News:Scientists shed new light on walking 2
(Date:10/30/2014)... 30, 2014 Stryker Orthopaedics, the Official Joint ... is rounding out its debut year of the relationship ... Scottsdale, AZ. This marks the eleventh tournament ... that the brand has activated on-site with the "Stryker ... fans on the importance of joint health.  ...
(Date:10/30/2014)... , Oct. 30, 2014 WuXi PharmaTech (Cayman) Inc. ... capability and technology platform company serving the pharmaceutical, biotechnology, ... China and the United States ... office in the Tel Aviv ... will promote WuXi,s broad platform of integrated R&D services ...
(Date:10/30/2014)... -- Boston Scientific Corporation (NYSE: BSX ) ... Annual Healthcare Conference on Tuesday, November 11, 2014 in ... , executive vice president and chief financial officer, will ... 8:00 a.m. PT followed by a question and answer ... and question and answer session will be available to ...
Breaking Medicine Technology:Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 2Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 3Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 4WuXi AppTec Launches Representative Office in Israel, Forms Strategic Collaboration with Pontifax 2Boston Scientific To Participate In 2014 Credit Suisse Annual Healthcare Conference 2
... March 20 Optimum Health Regeneration,Center announced the ... management and impaired mobility. This New Mexico family, ... significant improvements in reduced pain,increased physical mobility and ... umbilical cord stem cells and ozone therapy at ...
... IDM Pharma, Inc.,(the Company) (Nasdaq: IDMI ... a clinical protocol finalized with the U.S. Food ... eligible,high-risk osteosarcoma patients through a compassionate access study., ... the increasing number of,requests for compassionate access to ...
Cached Medicine Technology:Family of Three Americans Become Pain Free and Improve Their Quality of Life With Stem Cell Treatment in Mexico 2IDM Pharma Announces Availability of Mifamurtide (L-MTP-PE) Through Compassionate Access Study 2IDM Pharma Announces Availability of Mifamurtide (L-MTP-PE) Through Compassionate Access Study 3IDM Pharma Announces Availability of Mifamurtide (L-MTP-PE) Through Compassionate Access Study 4IDM Pharma Announces Availability of Mifamurtide (L-MTP-PE) Through Compassionate Access Study 5
... Liters of pure water, Complete, Compact Systems ... Water,Millipores compact S.D.S. Storage and Distribution Systems ... liters of purified water produced by Elix ... purity of stored water, provide effective protection ...
... range of Milli-Q ultrapure water systems ... requirements. Each of the five new ... target contaminants detrimental to particular applications ... ICP-MS. The systems incorporate a high ...
... a range of Milli-Q ultrapure water ... quality requirements. Each of the five ... specifically target contaminants detrimental to particular ... and ICP-MS. The systems incorporate a ...
... range of Milli-Q ultrapure water systems ... requirements. Each of the five new ... target contaminants detrimental to particular applications ... ICP-MS. The systems incorporate a high ...
Medicine Products: