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Helping preterm babies get the best start
Date:6/27/2011

Babies born prematurely could be at greater risk of developing kidney diseases later in life according to a landmark study investigating the impacts of preterm birth on kidney development.

The Monash University study is identifying new strategies for minimising the consequences of being born preterm, which accounts for around eight per cent of births each year in Australia.

By comparing the kidneys of babies born prematurely with those born after the full nine-month gestation, the research team, led by Associate Professor Jane Black from the Department of Anatomy and Cell Biology, identified that preterm babies had far fewer nephrons the 'building blocks' that make our kidneys.

"An average person has around 800,000 to 1.5 million nephrons and the number we have at birth is the number we have for life," Associate Professor Black said.

"We have shown that babies born preterm have less nephrons, in the range of 400,000 600,000. This is because nephron development occurs in the last few weeks of pregnancy, so babies born preterm have not had time to complete the developmental process."

"Even moderate preterm babies, those born within four weeks of full gestation, who were previously considered to have achieved 'normal' development, were found to have far fewer nephrons and underdeveloped kidneys."

Associate Professor Black said the findings were of critical importance because of the known link between having fewer nephrons and renal, or kidney, diseases.

"The more nephrons you have the more 'solid' a structure your kidneys will have. When we look at kidneys that have fewer nephrons, abnormalities are present, which indicates that preterm babies could be much more susceptible to renal disease and possible kidney failure later in life," Associate Professor Black said.

"Particularly in the last 30 years, we have had great successes with preterm births and today even babies born 26 weeks premat
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Contact: Monash Media and Communciations
media@monash.edu
61-399-034-840
Monash University
Source:Eurekalert

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