Navigation Links
Help for children with sick hearts
Date:3/2/2009

These bacteria carry a special protein sequence, the so-called PARF motif, on their surface. In the renowned journal PLoS ONE Singh Chhatwal and his colleague Patric Nitsche-Schmitz of the Helmholtz Centre for Infection Research (HZI) in Braunschweig illustrate the role played by PARF in the development of rheumatic heart disease. With this knowledge they are developing a test system that is able to recognise and prevent the disease at an early stage.

"PARF means 'peptide associated with rheumatic fever'," explains Nitsche-Schmitz. "It is a small section from a bacterial surface protein , which is used by the streptococcus to adhere to our cells and cause disease." Rheumatic fever develops from harmless sore throats amongst children in India, Australia and Africa in particular. The reason: inadequate medical treatment: if children with a streptococcus infection in the throat receive no or inadequate antibiotic treatment, then the surviving bacteria with the PARF sequence on their surface will adhere to their collagen. Collagen is present throughout the body as a major component of bone and cartillage it determines shape and structure of our body and it strengthens the connective tissue of the skin, the heart valves and blood vessels with its high resistance to tensile forces. Adhesion of PARF-bearing streptococci to collagenconfuses our immune system and our body's defence system not only targets the bacteria, but also healthy and vital collagen. The auto-immune disease rheumatic fever breaks out. If this in turn also fails to be treated correctly, the consequence is rheumatic heart disease: the heart valves, rich in collagen, become inflamed and cease to function.

Overall, only around five percent of all throat infections with streptococci result in an auto-immune disease. In order to filter out these five percent and treat them at an early stage, the Braunschweig infection researchers are developing a simple test strip that reacts
'/>"/>

Contact: Dr. Bastian Dornbach
bad@helmholtz-hzi.de
49-053-161-811-407
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Children of depressed moms do better when dad is involved, SLU researcher finds
2. High pollution linked to poor lung function growth in children in Mexico City
3. NYC-area 1st: Morgan Stanley Childrens Hospital performs transcatheter pulmonary valve replacement
4. Obese Children Miss More School Days
5. Ultra-Runner to Run 63 Marathons in 63 Days for Children with Incurable Disease
6. Psoriasis Cure Now offers Back to School Resources for Parents of Children with Psoriasis
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Practice-based intervention has sustained benefits for children and families
10. 1.5 million children could be saved
11. Annual flu shot cuts need for doctors visits, hospitalization among children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... 29, 2014, 2 PM US Eastern Time)The current ... inject antibodies, commonly produced in animals, to neutralize ... from safety to difficulties in developing, producing and ... New research led by Charles Shoemaker, Ph.D., professor ... Health at the Cummings School of Veterinary Medicine ...
(Date:8/29/2014)... The microbiology testing sector is one of the ... is also the hugest challenge facing suppliers during these ... of AIDS – still the world’s key health threat ... opportunistic infections (OIs); bioterrorism threat; advancements in technologies for ... Although for certain infections the etiology remains a mystery, ...
(Date:8/29/2014)... FRIDAY, Aug. 29, 2014 (HealthDay News) -- Prostate cancer ... good treatment decisions. This can lead to worse quality ... The study included 70 men, with a median age ... cancer. Poor understanding of the disease was associated ... less confidence that the treatment would be effective, the ...
(Date:8/29/2014)... 2014 Edvance360, a leading provider of ... online teaching, as well as 2011 winner and six-time-finalist ... Management System, announced that Brooke Education Services, Northwest Academy, ... Interactive Advertising Bureau of Canada (IAB Canada), StarSVCS, and ... are delighted to welcome each new client to the ...
(Date:8/29/2014)... is a U.S. Food and Drug Administration (FDA)-approved ... raloxifene is as effective at reducing fracture risk ... by suppressing bone loss. With the use of ... respectively), researchers carried out experiments at the U.S. ... at Argonne National Laboratory that revealed an additional ...
Breaking Medicine News(10 mins):Health News:Mice study shows efficacy of new gene therapy approach for toxin exposures 2Health News:Infectious Disease Testing Universe Examined in New VPG Research Report Available at MarketPublishers.com 2Health News:Infectious Disease Testing Universe Examined in New VPG Research Report Available at MarketPublishers.com 3Health News:Faced With Prostate Cancer, It Helps to Know the Enemy 2Health News:Edvance360 Continues to Experience Growth in Corporate, K-12, Health, and Non-Profit Sectors 2Health News:Revealing a novel mode of action for an osteoporosis drug 2
... ... Roberto Giraldo shows that AIDS is a result of multiple, repeated and chronic exposure to ... and most of all, emotional. , ... Oakland, CA (PRWEB) November 8, 2009 -- From Nov. 6 – 8, 2009, ...
... Nov. 7 Today, the House of Representatives passed ... amendment to the "Affordable Health Care for America Act" ... preventing federal funding for abortion and for benefits packages ... who receive affordability credits and those who do not, ...
... H.R. 3961 to Secure the Stability of Medicare , ... M.D., President, American Medical Association. , (Logo: http://www.newscom.com/cgi-bin/prnh/20081209/AMALOGO ... the House health reform bill, which will help improve the ... passage of H.R. 3961 to secure the stability of the ...
... Calif., Nov. 8 March of Dimes hosted the ... individuals who are celebrating the birth of their children ... commitment to improve the health of babies. As ... Month campaign, celebrities and special guests were urged to ...
... , Jacquelyn T. Coleman (CT), David A. Cook ... David L. Tarver (LA) Honored , CHICAGO, Nov. ... five medical society executive leaders with achievement awards to ... the medical profession. The awards were presented at the ...
... , WASHINGTON, Nov. 7 The U.S. bishops November ... vote for the Stupak-Ellsworth Amendment to the health care ... current federal law on abortion funding and conscience protections ... 3962)," they said. , The letter was signed by ...
Cached Medicine News:Health News:Revolutionary New Views on AIDS Highlight the Rethinking AIDS 2009 Congress; Emotional Issues can be a Significant Contributing Factor 2Health News:Revolutionary New Views on AIDS Highlight the Rethinking AIDS 2009 Congress; Emotional Issues can be a Significant Contributing Factor 3Health News:Family Research Council Praises Passage of Pro-life Amendment to Health Care Bill 2Health News:AMA Hails House Passage of Health Reform Bill (H.R. 3962) 2Health News:Hollywood Stars Joined in a Celebration of Babies 2Health News:Hollywood Stars Joined in a Celebration of Babies 3Health News:AMA Honors Medical Society Executives 2Health News:Bishops Urge Passage of Stupak-Ellsworth Anti-Abortion Amendment for Health Reform Bill 2
(Date:8/29/2014)... Research and Markets  has announced the ... Devices Market 2014-2018" report to their offering. ... cells that connect, support, or surround bones. There are ... ligaments, cartilage, fascia, and other fibrous tissues. Repetitive use, ... age result in wear and tear in these tissues. ...
(Date:8/28/2014)... 28, 2014 Reportlinker.com announces ... is available in its catalogue: ... Services Industry (U.S.): Analytics, Extensive Financial ... 2021, NAIC 541380 ... Testing Laboratories, Safety and Compliance Services ...
(Date:8/28/2014)... -- Pharmatech initiated enrollment for its AccessPPM program ... for matching cancer patients to cancer clinical trials. ... cancers, disease staging, and genetic mutations - which ... the first place. The challenge that the industry ... well known to the patient or even their ...
Breaking Medicine Technology:Global Orthopedic Soft Tissue Repair Devices Market 2014-2018: Key Vendors are ArthroCare, Biomet, DePuy Synthes and Smith & Nephew 2Global Orthopedic Soft Tissue Repair Devices Market 2014-2018: Key Vendors are ArthroCare, Biomet, DePuy Synthes and Smith & Nephew 3Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 2Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 3Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 4Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 5Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 6Enrollment in Pharmatech's Revolutionary AccessPPM Program Launches 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: