Navigation Links
Helicobacter pylori can multiply in autophagic vesicles
Date:1/27/2009

Helicobacter pylori, a Gram-negative, flagellated, microaerophilic bacterium, can selectively colonize in the human stomach. Its infection is widespread throughout the world, and is present in about 50% of the global human population with 80% in developing countries and 20-50% in industrialized countries. Infection of the stomach with H. pylori induces a local immune response with infiltration of the mucosa by macrophages, neutrophils and lymphocytes. Although the innate and adaptive immune responses are activated, the bacterium is rarely eliminated and infections can last for decades if left untreated. Most infections are asymptomatic, but overt diseases can occur in 10-20 % of infected individuals. The disease spectrum ranges from gastritis to peptic ulceration disease. A long-term chronic infection will increase the risk to gastric adenocarcinoma and mucosa-associated lymphoid-tissue lymphoma. It has been classified as a class I carcinogen by the WHO. Despite intensive studies, and the award of the 2005 Nobel Prize in Physiology for the discovery of the bacterium H. pylori by Robin Warren and Barry Marshall, our understanding of H. pylori-infection-caused disease is still limited. H. pylori has evolved several mechanisms to increase its adherence and persistence in the host. In addition, it must also evade immune clearance. Elimination of H. pylori by phagocytes is inefficient because H. pylori exhibits several virulence factors to evade opsonization, retard phagocytosis, and disrupt membrane trafficking and phagosome maturation after internalization of the microorganism.

In the February 2009 issue of Experimental Biology and Medicine researchers at the National Cheng Kung University, Tainan, Taiwan, have reported a novel phenomenon involving autophagosome formation induced by H. pylori infection and subsequent adoption of these autophagic vesicles by H. pylori for replication in macrophages. The fate of H. pylori is dependent on the strains (isolates) as well as the host macrophages used. Several clinical isolates of H. pylori from Taiwanese patients, but not standard strains, can multiply in the double-layered vesicles of macrophages. The senior author, Dr. Huan-Yao Lei stated that "The autophagy induction by H. pylori is not only found in macrophages, but also in dendritic cells and gastric epithelial cells". This new finding has several implications for the life cycle of H. pylori in the host. H. pylori can be considered as a kind of intracellular microorganism because it can invade host cells to undergo replication within the autophagosome. The bacterium's residence inside infected cells not only increases its resistance to antibiotic treatment, but also avoids neutralization by anti-H. pylori antibodies. In view of the critical role of dendritic cells in presenting H. pylori antigen to initiate the immune response, it is possible that H. pylori-infected dendritic cells induce an inadequate immune response to H. pylori infection that might hinder the clearance of this bacterium. Alternatively, the various immunopathogenesis during the H. pylori-caused diseases might be caused by an unbalanced Th-1 or Th2-mediated response post infection. Finally, the micro-heterogeneity of Taiwanese H. pylori isolates used in this study provides an important hint as to why this microorganism causes so broad a spectrum of diseases. Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine stated "This study also has potential implications for new anti-H. pylori drugs that target the enhancement of autophagy. Dr. Lei and his co-workers have provided an important contribution to our understanding of H. pylori infection."


'/>"/>

Contact: Dr. Huan-Yao Lei
hylei@mail.ncku.edu.tw
886-623-53535
Society for Experimental Biology and Medicine
Source:Eurekalert

Related medicine news :

1. How do Lactobacilli treat Helicobacter pylori-related diseases?
2. Helicobacter pylori inhibits intercellular communication of cultured gastric cells
3. Gastric juice for diagnosis of H. pylori infection in patients on proton pump inhibitors
4. How is H pylori adhesion to gastric cells associated with MUC1 mucin VNTR size?
5. A low prevalence of H pylori in HIV-positive patients
6. Bernadette Peters Joins Board of Directors of Standing Tall, Innovative Program for Multiply Disabled Children
7. Extracts of catfish caught in polluted waters cause breast cancer cells to multiply
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... (PRWEB) , ... June 28, 2017 , ... Anyone with a remote control has seen ... can do it, you the flipper will get rich in no time. But what ... wrong things can get for the buyer of a flipped house. An email recently ...
(Date:6/28/2017)... Philadelphia, PA (PRWEB) , ... June 28, 2017 ... ... will host a one-day corporate governance program for mid-market executives as a kick-off ... will be held Sunday, Sept. 24, 2017 on the University of Pennsylvania campus, ...
(Date:6/28/2017)... ... 28, 2017 , ... Canadian Zeolite Corp. (the “Company”) (TSX.V: ... study conducted by the University of Saskatchewan in partnership with PotashCorp, Agrium and ... groundwater. As a part of the study, batch adsorption experiments were conducted with ...
(Date:6/28/2017)... ... June 28, 2017 , ... Designers ... to communities in northern Virginia and DC, is announcing a cooperative charity event ... with Alzheimer’s and other disorders that lead to memory impairment. , The Insight ...
(Date:6/27/2017)... (PRWEB) , ... June 27, 2017 , ... ... a cosmetic treatment, according to survey data released today by the American ... Cosmetic Dermatologic Procedures indicates the percentage of consumers considering a cosmetic medical ...
Breaking Medicine News(10 mins):
(Date:6/5/2017)... Kohll,s Pharmacy & Homecare is the first distributor of ... . The Raizer is a simple battery operated mobile ... an almost-standing position within a few minutes. The ... and does not require any extra effort besides a ... can operate it, and lightweight and portable so ...
(Date:6/1/2017)... BELL, Pa. , June 1, 2017 ... (PRN) and Veterinarian Recommended Solutions (VRS), and KD Pharma ... investment in Nutriceutical Holdings by KD Pharma Group. KD ... Holdings with the option to acquire the entire company. ... partner in KD. They are committed to growing the ...
(Date:5/30/2017)... TEL AVIV, Israel , May 30, 2017 /PRNewswire/ ... clinical stage pharmaceutical Company specializing in the development ... management will present a company overview at three ... The 7th Annual LD Micro Invitational: ... Date:                     ...
Breaking Medicine Technology: