Navigation Links
Hebrew University researchers discover expanded role for cancer-causing gene
Date:11/8/2010

Jerusalem, November 7, 2010 Researchers at the Hebrew University of Jerusalem have discovered that Vav1 an oncogene (cancer-causing gene) found in recent years to be one of the factors in tumorous tissue growth -- plays a wider role in several types of cancer than had previously been thought. The discovery has implications for further concentration on targeting this gene in cancer research.

The work of the researchers, led by Dr. Shulamit Katzav-Shapira of the Institute for Medical Research Israel-Canada at the Hebrew University of Jerusalem Faculty of Medicine, was published recently in the Journal of Biological Chemistry.

Vav1 has been known to be involved in alterations in gene expression in the immune system, where it is physiologically expressed. Vav1 was discovered a few years ago by Katzav-Shapira when she was working in the National Cancer Institute laboratory of Dr. Mariano Barbacid in the US. Since this newly identified gene represented the sixth oncogene detected in Dr. Barbacid's laboratory, it was designated by Katzav-Shapira as Vav (six in Hebrew) 1.

Vav1 is involved in the process whereby cells are "triggered" into action. When receptors on the surface of a cell, known as growth factor receptors, receive signals for growth, they relay this information into the cell. This chain of command is often called a "signal transduction cascade" or a "pathway." Signal transduction cascades play a fundamental role in controlling normal cell proliferation, differentiation, cell adhesion, spontaneous movement, and programmed cell death.

Mutations in the proteins driving this signal transduction process are among the main causes for driving cells to develop into cancer. Thus, identification of the signal transducers that are involved in malignant transformation is a prerequisite for understanding cancer and improving its diagnosis and treatment. Since Vav1 was shown to be involved in events leading to alte
'/>"/>

Contact: Jerry Barach
jerry@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Collagen manufactured from transgenic tobacco plants at Hebrew University
2. Hebrew University added to Singapore research program
3. University of Virginia Health System Medical Laboratories Selects Sunquest's Specimen Collection Solution
4. Akron Institute of Herzing University Launches Its First Bachelors Degree Programs to Prepare Students for Even Greater Success in Business, Health Care and IT
5. Most pandemic plans in Ontario hospitals have not been tested: Queens University study
6. San Diego State University and BIOCOM Institute Receive $4.95 Million Grant: The BRIDGE Project, Linking Education to Employment in San Diegos Life Sciences Industry
7. Smithsonian Institution, Arizona State University announce education and research partnership
8. Untreated poor vision in elderly linked to dementia, University of Michigan study shows
9. Giarmarco, Mullins & Horton, P.C. President Joseph F. Page to Speak at University of Michigan
10. Arizona State Universitys Decision Theater offers balance to an off-kilter world
11. Forest City Announces Joint Venture with Health Care REIT for University Park Life Science Properties
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hebrew University researchers discover expanded role for cancer-causing gene
(Date:8/21/2014)... PA (PRWEB) August 21, 2014 The ... Crossing Historic Park in Washington Crossing, Pennsylvania on Thursday, ... the park. “We have been looking for different ways ... said Matt Kiernan, Partner with Pharmica Consulting. “When we ... part of U.S. history, we jumped at the opportunity.” ...
(Date:8/21/2014)... She was 12 years old when the unthinkable happened – ... correct her frequent headaches failed. , In her new ... her journey of overcoming devastating obstacles involving dual disability, greed ... justice for years. , “My faith in God helped ... light,” Strom-Stewart said. “But it took me more than a ...
(Date:8/21/2014)... 21, 2014 The rising numbers of teen ... Beach, FL. For many years, countless lives have been lost ... the community a new helpline was established to provide a ... who are seeking to overcome their youth substance abuse ... Beach helpline at (561) 257-4053, parents and their teens can ...
(Date:8/21/2014)... Michael E. Steuer , local doctor in Memphis, TN, ... City with recent philanthropy at local synagogue. “The state of ... says friend and Rabbi David Julian of Or Chadash in ... in-house for the needy and teaching Hebrew to students, Steuer ... synagogue. And to remain close with the development of Israel, ...
(Date:8/21/2014)... SC (PRWEB) August 21, 2014 ... of seven start-ups selected to participate in the ... provides entrepreneur mentorship, curriculum sessions and valuable resources.he ... businesses in the region. Each start-up selected for ... support in order to help businesses grow quickly, ...
Breaking Medicine News(10 mins):Health News:Pharmica Spends the Day Helping to Preserve Washington Crossing Historic Park 2Health News:The Dramatic, Uplifting Story from a Brain Injured Woman 2Health News:Troubled Teens in Boynton Beach, FL Turn to Helpline for Valuable Assistance 2
... possessing gun in assault situation 4.5 times more likely to be ... In a first-of-its-kind study, epidemiologists at the University of ... not protect those who possessed them from being shot in an ... 4.5 times more likely to be shot in an assault than ...
... ... today that Wayne Cockburn, President and CEO will present an overview of Muscle ... pain, neurology, medical device , ... Huntington Beach, CA (PRWEB) September 30, 2009 -- iTech Medical, Inc. (OTCBB: ...
... ... Publishing releases CNS Complications in the Immunocompromised Patient, an ABR-approved online radiology self-assessment ... ... 2009 -- Oakstone Medical Publishing announces the launch of the ABR-approved radiology online ...
... , WASHINGTON, Sept. 29 The American Federation of Government Employees ... Management that premiums under FEHBP would be rising by an average ... average is the fact that for 60% of the enrollees in ... premiums will be going up by 15% for self coverage and ...
... Cadence Pharmaceuticals, Inc. (Nasdaq: CADX ), a biopharmaceutical ... candidates principally for use in the hospital setting, announced ... will present the company,s corporate overview on Tuesday, October ... during the JMP Securities Healthcare Focus Conference at the ...
... and post-menopausal women who self-rated themselves as being sexually ... scores for "positive well-being" and "vitality," compared with sexually ... active more than twice a month. The study, ... , also uncovered a positive association between age and ...
Cached Medicine News:Health News:Penn Study Asks, Protection or Peril? Gun Possession of Questionable Value in an Assault 2Health News:Penn Study Asks, Protection or Peril? Gun Possession of Questionable Value in an Assault 3Health News:iTech Medical to Present at BioContact Qubec 2009 2Health News:iTech Medical to Present at BioContact Qubec 2009 3Health News:iTech Medical to Present at BioContact Qubec 2009 4Health News:iTech Medical to Present at BioContact Qubec 2009 5Health News:Oakstone Medical Publishing Introduces an Online ABR Qualified Self-Assessment Module for Radiologists Designed to Satisfy MOC Requirements 2Health News:Sexually satisfied women have better general well-being and more vitality 2Health News:Sexually satisfied women have better general well-being and more vitality 3
(Date:8/20/2014)... PLAINFIELD, N.J. , Aug. 20, 2014 PTC Therapeutics, ... will participate at two upcoming investor conferences: - ... Seasons Hotel in Boston on Wednesday, ... Biotech Conference at The Mandarin Oriental Boston on Thursday, September ... present a company update at the Bank of America Merrill ...
(Date:8/20/2014)... YORK , Aug. 20, 2014 ... is available in its catalogue: The ... IVD Industry http://www.reportlinker.com/p01618927/The-Impact-of-Healthcare-Reform-PPACA-On-the-US-IVD-Industry.html ... Act" (H.R. 3590) is complex legislation that affects ... of its provisions are beginning to take effect ...
(Date:8/20/2014)... 20, 2014 Reportlinker.com announces that ... in its catalogue: Personal Accident ... and Opportunities to 2017 ... The report provides in depth market analysis, ... accident and health insurance segment, including: • ...
Breaking Medicine Technology:PTC Therapeutics to Participate at Upcoming Investor Conferences 2The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 2The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 3The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 4The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 5The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 6Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 2Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 3Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 4Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 5Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 6Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 7Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 8Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 9Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 10Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 11Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 12Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 13Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 14Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 15Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 16Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 17Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 18Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 19Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 20Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 21Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 22Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 23
... REDWOOD CITY, Calif., March 19, 2012 Ingenuity Systems, ... life science researchers, today announced that the Weill Cornell ... iReport for use in its sequencing core facility.  Variant ... the output of whole genome and exome sequencing experiments ...
... 19, 2012  Johnson & Johnson (NYSE: JNJ) will provide ... parties on Monday, March 26th at approximately 10:30 ... College of Cardiology (ACC) Annual Scientific Sessions in ... of the EINSTEIN-PE study in treating patients with ...
Cached Medicine Technology:Weill Cornell Medical College Selects Ingenuity® Variant Analysis™ and Ingenuity® iReport™ for Sequencing Core Facility 2
Adjustable Velcro© closures at crown and behind the neck distinguish this immediate post-op face and chin garment for maximum support and compression....
A CDI original design with seams on the outside, away from the skin, adjustable fit and removable/adjustable back strap, provides patient comfort and needed compression....
Ideal for autoplasty and liposuction of chin and cheeks...
Applies pressure on scalp to stretch it before surgery...
Medicine Products: