Navigation Links
Hebrew U. scientists identify molecular basis for DNA breakage
Date:7/19/2011

Jerusalem, July 19, 2011 - Scientists from the Hebrew University have identified the molecular basis for DNA breakage, a hallmark of cancer cells. The findings of this research have just been published in the journal Molecular Cell.

The DNA encodes the entire genetic information required for building the proteins of the cell. Hence, DNA breaks disrupt the proteins and lead to changes in the cell function. These changes can lead to defects in the control of cellular proliferation resulting in cancer development.

Using cutting edge technologies, researchers Prof. Batsheva Kerem and doctoral student Efrat Ozeri-Galai, of the Alexander Silverman Institute of Life Sciences in the Faculty of Science were able to characterize for the first time the DNA regions which are the most sensitive regions to breakage in early stages of cancer development. This is a breakthrough in our understanding of the effect of the DNA sequence and structure on its replication and stability.

"A hallmark of most human cancers is accumulation of damage in the DNA, which drives cancer development," says Prof. Kerem. "In the early stages of cancer development, the cells are forced to proliferate. In each cycle of proliferation the DNA is replicated to ensure that the daughter cells have a full DNA. However, in these early stages the conditions for DNA replication are perturbed, leading to DNA breaks, which occur specifically in regions defined as 'fragile sites'."

In this research Prof. Kerem and Ozeri-Galai used a sophisticated new methodology which enables the study of single DNA molecules, in order to study the basis for the specific sensitivity of the fragile sites. The findings are highly important since they shed new light on the DNA features and on the regulation of DNA replication along the first regions that break in cancer development.

The results show that along the fragile region there are sites that slow the DNA replication and even stop it. In order to allow completion of the DNA replication the cells activate already under normal conditions mechanisms that are usually used under stress. As a result, under conditions of replication stress, such as in early cancer development stages, the cell has no more tools to overcome the stress, and the DNA breaks.

The results of this study reveal the molecular mechanism that promotes cancer development. Currently, different studies focus on the very early stages of cancer development aiming to identify the events leading to cancer on the one hand and on their inhibition, on the other. The result of the current research identified for the first time DNA features that regulate DNA replication along the fragile sites, in early stages of cancer development. In the future, these findings could lead to the development of new therapeutic approaches to restrain and/or treat cancer.


'/>"/>

Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert  

Related medicine news :

1. Three senior Hebrew University faculty members receive Kaye Awards for innovations
2. Group led by Hebrew University professor chosen as Israeli Center for Research Excellence
3. Hebrew University researchers show octopuses make some pretty good moves
4. Hebrew University researchers demonstrate why DNA breaks down in cancer cells
5. Mechanism for invasion of tumorous cells discovered by Hebrew University researchers
6. Hebrew University researchers discover expanded role for cancer-causing gene
7. Hebrew University added to Singapore research program
8. Collagen manufactured from transgenic tobacco plants at Hebrew University
9. Scientists Spot Possible Target in Ovarian Cancer
10. 7 in 1 blow: Scientists discover DNA regions influencing prostate cancer risk
11. Gold nanoparticles bring scientists closer to a treatment for cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hebrew U. scientists identify molecular basis for DNA breakage
(Date:6/26/2016)... Viejo, California (PRWEB) , ... June 26, 2016 , ... ... Final Cut Pro X. , "Film editors can give their videos a whole new ... said Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels contains ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... they have been diagnosed with endometriosis. These women need a treatment plan to ... a comprehensive approach that can help for preservation of fertility and ultimately achieving ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June ... , brings up a new, often overlooked aspect of head lice: the parasite’s ability to ... is not a common occurrence, but a necessary one in the event that lice have ...
(Date:6/25/2016)... ... 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned ... the David Geffen School of Medicine at UCLA. He trained in Internal Medicine at ... fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Any dentist who has made an implant ... process. Many of them do not even offer this as ... high laboratory costs involved. And those who ARE able to ... a high cost that the majority of today,s patients would ... Parsa Zadeh , founder of Dental Evolutions Inc. and inventor ...
(Date:6/23/2016)... Research and Markets has announced the ... 2016 - Forecast to 2022" report to their offering. ... up to date financial data derived from varied research sources ... with potential impact on the market during the next five ... comprises of sub markets, regional and country level analysis. The ...
(Date:6/23/2016)... , June 23, 2016 , ... on Thursday, July 7, 2016 , , , , LOCATION: ... , , , , EXPERT PANELISTS:  , , , ... Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and ... The global pharmaceutical industry is witnessing an exceptional era. ...
Breaking Medicine Technology: