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Heavy Beer Drinking, Genetics May Raise Risk of Stomach Cancer
Date:4/4/2011

By Alan Mozes
HealthDay Reporter

MONDAY, April 4 (HealthDay News) -- Heavy beer drinkers who carry a gene mutation involved in the metabolism of alcohol may face a higher risk than others of developing stomach cancer, new European research suggests.

Having a certain genetic variant and drinking roughly three 12-ounce cans or more of beer a day appears to markedly increase the risk of "non-cardia gastric cancer," a study found.

"This is the first time we've seen this genetic variant associated with gastric cancer risk, so we need to emphasize that this result needs to be replicated in other populations," cautioned study lead author Eric Duell, a senior epidemiologist at the Catalan Institute of Oncology in Barcelona, Spain.

"For now, if people want to know whether they should go out and get tested for this variant or whether they should stop drinking if they're heavy beer drinkers, I would basically say that we're not there yet," added Duell.

"All we can currently say is that the genetic variant is associated with increased risk, heavy drinking is associated with increased risk, and when the two are together, the risk is even worse," he noted.

The study focused on the "rs1230025 variant" located among a group of three genes already linked to alcohol digestion.

And although the results focus on the coupling of the mutation with heavy drinking, the authors also found that either factor on its own also raised stomach cancer risk, although less dramatically. Namely, cancer risk was elevated among non-drinkers bearing the mutation and among heavy drinkers without the mutation.

Duell and his colleagues are slated to present their findings Monday in Orlando, Fla., at the annual meeting of the American Association for Cancer Research. Findings presented at meetings are considered preliminary until published in a peer-reviewed journal.

Globally, stomach cancer is the se
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