Navigation Links
Heat shock proteins are co-opted for cancer
Date:9/20/2007

CAMBRIDGE, Mass. (Sept. 20, 2007) A Jekyll-Hyde mechanism that both protects healthy cells and enables cancer cells could be the basis for new cancer-fighting drugs.

Scientists in the laboratory of Whitehead Member Susan Lindquist have discovered that a certain transcription factora protein that binds to specific areas of the genome and acts to switch genes on and offknown to aid in handling stresses also facilitates the survival of cancer cells.

According to the study, which appears online in Cell on Sept. 20, this transcription factor may be the basis for powerful new ways to fight cancer.

The transcription factor is the master regulator of cells protective heat-shock responsea complex and multifaceted defense system that kicks in when an organism is exposed to increased temperature, infection, toxins or other stresses. The heat-shock response is thought to have existed for more than a billion years and is found in organisms from bacteria to fruit flies to humans.

Heat-shock transcription factors turn on genes for helpful chaperone proteins that help keep proteins from going bad. If proteins form unhealthy clumps, heat-shock proteins (HSPs) pull them apart. If proteins misfold, HSPs help them refold. If the errant proteins are too far gone, HSPs ship them off to be destroyed.

Postdoctoral associate Chengkai Dai and his colleagues looked at the role of heat-shock factor 1 (HSF1), the master regulator of the heat-shock response, in enabling normal cells to turn into cancer cells.

This work provides the first direct evidence of an important role for HSF1 in helping cells to undergo a malignant transformation, says co-author Luke Whitesell, a research scientist in the Lindquist lab.

While the transcription factor does not itself cause the transformation of a normal cell into a cancer cell, it orchestrates a network of core functions in the cancer cells that govern their proliferation, survival, protein synthesis and metabolism.

In mice, an HSF1 deficiency drastically limited tumor formation induced by either a chemical carcinogen or a cancer-causing genetic mutation.

Using cells from a variety of human tumors, Dai showed that depriving the cancer cells of HSF1 strongly suppressed their ability to grow and survive. We propose that HSF1 could provide a uniquely effective target for the discovery of broadly active anticancer agents, says Lindquist.

Its increasingly apparent, Whitesell comments, that many biological mechanisms can play dual rolessometimes beneficial, sometimes not.

It makes perfect sense to us that HSF1 plays this dual role, Dai says. It has been shown that HSF1 is involved in protecting against neurodegeneration, in which brain cells die slowly over time. In cancer, the opposite is true: cancer cells dont die. Ironically, cancer cells hijack and exploit this evolutionarily conserved self-protective function of HSF1.

In fact, he says, cancer cells appear much more sensitive than normal cells to the loss of HSF1 function.

It will be interesting to see how the insights gained from studies such as this one can be applied to develop useful therapeutics, Whitesell says. The next step is to look for existing compounds that induce or inhibit the heat-shock response in cells. The challenge will be to manipulate the target for therapeutic advantage without tipping the scales too much or in the wrong places.


'/>"/>

Contact: Eric Bender
bender@wi.mit.edu
617-258-9183
Whitehead Institute for Biomedical Research
Source:Eurekalert

Related medicine news :

1. Shock it to Heal!!
2. Aprotinin in the treatment of hemorrhagic shock trauma patients
3. New Implantable Cardioverter Defibrillators to avoid unnecessary shocks
4. Shocked out of drugs?
5. Shock Wave Therapy Increase The Risk Of Diabetes
6. Health Experts Shocked As 11-year-old Girl To Be UKs Youngest Mother
7. Cardiogenic Shock is the Leading Cause of Death for Heart Attack Patients
8. Radioprotective effect of Heat Shock Proteins
9. New Study Finds On/Off Switch for Septic Shock
10. Are call centers turning a deaf ear to potential acoustic shocks?
11. Hong Kong - HIV Test Shock Sparks Warning
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... March 23, 2017 , ... The IoT (Internet of Things) is revolutionizing ... a huge impact on businesses and individual consumers alike. Laboratories can maximize their ... a value anywhere from $4 trillion to $11 trillion dollars by the year 2025. ...
(Date:3/23/2017)... TX (PRWEB) , ... March 23, 2017 , ... March ... organs that pack a punch when it comes to maintaining good health. Every day, ... 30 minutes, your kidneys filter every drop of your blood, eliminating waste, regulating fluid ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... program owned and organized by HMP Communications Holdings, LLC, today announced that ... within its nationwide network of wound centers interested in becoming Certified Wound Specialist ...
(Date:3/23/2017)... ... March 23, 2017 , ... After raising more than $1.135 million ($1,479,231 AUD) ... travel pillow in crowdfunding history, has established a U.S. Headquarters in New York ... to Americans. , “We’re excited to be operating on U.S. shores, where most of ...
(Date:3/23/2017)... Grants Pass, OR (PRWEB) , ... March 23, 2017 , ... ... Power of Water, Global Climate Change and Your Health on VoiceAmerica, recently talked on ... 22nd, but she also used the occasion to remind listeners of an important distinction. ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... March 23, 2017 Newborns are highly ... most vaccines because their young immune systems typically ... Children,s Hospital report achieving strong vaccine responses in ... model before human trials — by adding compounds ... In two simultaneous papers, they also describe improved ...
(Date:3/23/2017)... , March 23, 2017 /PRNewswire/ - INVICTUS MD ... IVITF; FRA: 8IS) Invictus MD announces that AB Laboratories ... in its licensed production facility under the Access to ... Hamilton, Ontario . The ... in October 2016, is currently operating at half capacity, ...
(Date:3/23/2017)... NEW YORK , March 23, 2017 /PRNewswire/ ... the NASDAQ Composite ended the trading session at ... edged 0.03% lower, to finish at 20,661.30; and ... 0.19%. Gains were broad based as six out ... This Thursday, Stock-Callers.com has initiated reports coverage on ...
Breaking Medicine Technology: