Navigation Links
Heart's Stem Cells Not Created Equally

Progenitor cells may not follow same pathways, researchers say

MONDAY, April 14 (HealthDay News) -- Not all heart cells are created by the same universal signal, a discovery that could lead to future treatments for congenital heart disease and heart attacks, U.S researchers say.

Experiments conducted on frogs challenge long-held beliefs that the stem cells that eventually develop into the heart's muscle tissue do so in reaction to the same cue.

"Not only does it tell us about how stem cells differentiate to create the heart, but it provides us with knowledge that may very well help us to repair heart muscle after a heart attack," researcher Dr. Cam Patterson, director of the Carolina Cardiovascular Biology Center at the University of North Carolina at Chapel Hill, said in a prepared statement.

The study was published online in the April 14 issue of the journal Developmental Cell and in the April 15 print edition.

The researchers manipulated genetic material in frog embryos so their cells would not produce a gene known as CASTOR, which had been linked to stem cell differentiation in the fruit fly.

Without CASTOR present, a small subset of cells at the base of an embryo's heart remained in a state of infancy while others developed. These infant cells, or progenitors, were later found to have developed into the outer walls of the heart's ventricles if they were allowed to progress normally.

This finding affects theories about the possibility of transplanting progenitor cells into the damaged area of the organ, such as heart-attack scarred muscle, in hope of creating healthy tissue. The theory supposes that all progenitors are the same.

"What we have found is that this belief simply isn't true," study senior author Frank Conlon, assistant professor of genetics in the UNC School of Medicine, said in a prepared statement. "Instead, there appear to be at least two types of progenitors, and we think there may be many more."

Conlon is now attempting to manipulate other genes in addition to CASTOR to determine how many types of heart cell progenitors exist. He hopes to verify his findings other animal models before searching for genetic counterparts in humans.

More information

The American Heart Association has more about common cardiovascular diseases.

-- Kevin McKeever

SOURCE: University of North Carolina at Chapel Hill, news release, April 14, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Healing Wounds and Hearts: Warrior Weekend Helps Soldiers Relax and Recover
2. Lack of Sleep Hurts Womens Hearts Most
3. Caring for Heart Patients Can Strain Hearts
4. Research Shows Alcohol Can Benefit the Hearts of New Drinkers
5. Pacemaker tune-up works chemical wonders on damaged hearts in dogs
6. King of Talk Celebrates Milestone With Quaker, The King of Hearts
7. Free For All on Leap Day to Get Hearts Pumping!
8. Childrens Heart Foundation (CHF) Hosts 4th Annual Arizona Swing For Their Hearts Golf Event
9. Study Finds Women Pay More Attention to Their Hair Than Their Hearts
10. Obesity Can Hurt Kids Hearts
11. Study Shows How Exercise Helps Womens Hearts
Post Your Comments:
Related Image:
Heart's Stem Cells Not Created Equally
(Date:12/1/2015)... D.C. (PRWEB) , ... December 01, 2015 , ... ... updated, comprehensive website detailing the important role that meat and poultry play ... in meat and poultry, a nutrition quiz where visitors can check their “meat ...
(Date:12/1/2015)... ... December 01, 2015 , ... Integrated Rental Services (“Integrated ... Industries International, LLC (“JII”). , With support from JII, Integrated Rental is poised ... hospitals, surgery centers, clinics, research labs and medical facilities across the United States. ...
(Date:12/1/2015)... ... 01, 2015 , ... Califia Farms , one of the fastest growing ... won top honors in Beverage World Magazine’s Global Packaging Design Awards, taking home the ... been selected as a 2015 U.S.A. Taste Champion in the American Masters of Taste ...
(Date:12/1/2015)... ... December 01, 2015 , ... December ... seen vast improvements in scientific research and discoveries, leading us to better understand ... and relief to those affected by HIV/AIDS. Mediaplanet’s cross-platform edition of “World AIDS ...
(Date:12/1/2015)... ... December 01, 2015 , ... The importance of ... is the focus of numerous abstracts accepted for presentation here, at the 101st ... Nine abstracts highlight the use of Volpara Solutions’ quantitative breast imaging software tools ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... N.J. , Dec. 1, 2015 ... held in San Francisco, CA ... solutions to the coronary marketplace. During a satellite ... in Stent Design to Minimize Restenosis", a renowned ... currently available Medinol NIRxcell™ CoCr Coronary Stent System ...
(Date:12/1/2015)... 2015 Relmada Therapeutics, Inc. (OTCQB: RLMD), a clinical-stage ... announced today that the company will present at the LD ... at the Luxe Sunset Boulevard Hotel in Los ... Relmada Therapeutics, will present on Thursday, December 3, at 9:00 ... . Please register at least 10 minutes prior to the ...
(Date:12/1/2015)...  InCarda Therapeutics, Inc. (InCarda), a privately-held biopharmaceutical company ... cardiovascular conditions via the inhalation route, today announced that ... Australia . InCarda is planning to undertake its ... in the first half of 2016. The company ... Adelaide and Melbourne.  In addition, ...
Breaking Medicine Technology: