Navigation Links
Heart's Stem Cells Not Created Equally
Date:4/14/2008

Progenitor cells may not follow same pathways, researchers say

MONDAY, April 14 (HealthDay News) -- Not all heart cells are created by the same universal signal, a discovery that could lead to future treatments for congenital heart disease and heart attacks, U.S researchers say.

Experiments conducted on frogs challenge long-held beliefs that the stem cells that eventually develop into the heart's muscle tissue do so in reaction to the same cue.

"Not only does it tell us about how stem cells differentiate to create the heart, but it provides us with knowledge that may very well help us to repair heart muscle after a heart attack," researcher Dr. Cam Patterson, director of the Carolina Cardiovascular Biology Center at the University of North Carolina at Chapel Hill, said in a prepared statement.

The study was published online in the April 14 issue of the journal Developmental Cell and in the April 15 print edition.

The researchers manipulated genetic material in frog embryos so their cells would not produce a gene known as CASTOR, which had been linked to stem cell differentiation in the fruit fly.

Without CASTOR present, a small subset of cells at the base of an embryo's heart remained in a state of infancy while others developed. These infant cells, or progenitors, were later found to have developed into the outer walls of the heart's ventricles if they were allowed to progress normally.

This finding affects theories about the possibility of transplanting progenitor cells into the damaged area of the organ, such as heart-attack scarred muscle, in hope of creating healthy tissue. The theory supposes that all progenitors are the same.

"What we have found is that this belief simply isn't true," study senior author Frank Conlon, assistant professor of genetics in the UNC School of Medicine, said in a prepared statement. "Instead, there appear to be at least two types of progenitors, and we think there may be many more."

Conlon is now attempting to manipulate other genes in addition to CASTOR to determine how many types of heart cell progenitors exist. He hopes to verify his findings other animal models before searching for genetic counterparts in humans.

More information

The American Heart Association has more about common cardiovascular diseases.



-- Kevin McKeever



SOURCE: University of North Carolina at Chapel Hill, news release, April 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Healing Wounds and Hearts: Warrior Weekend Helps Soldiers Relax and Recover
2. Lack of Sleep Hurts Womens Hearts Most
3. Caring for Heart Patients Can Strain Hearts
4. Research Shows Alcohol Can Benefit the Hearts of New Drinkers
5. Pacemaker tune-up works chemical wonders on damaged hearts in dogs
6. King of Talk Celebrates Milestone With Quaker, The King of Hearts
7. Free For All on Leap Day to Get Hearts Pumping!
8. Childrens Heart Foundation (CHF) Hosts 4th Annual Arizona Swing For Their Hearts Golf Event
9. Study Finds Women Pay More Attention to Their Hair Than Their Hearts
10. Obesity Can Hurt Kids Hearts
11. Study Shows How Exercise Helps Womens Hearts
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Heart's Stem Cells Not Created Equally
(Date:4/28/2017)... ... ... The Radiology Business Management Association (RBMA) is pleased to announce ... process has been in place since the RBMA was founded in 1968 with all ... Jim Hamilton, MHA, CMM, FRBMA, as president. Dr. Dickerson the chief executive officer for ...
(Date:4/28/2017)... ... April 28, 2017 , ... ... and College of Urgent Care Medicine will host industry leaders for the annual ... will help those in the industry adapt to the issues currently affecting urgent ...
(Date:4/28/2017)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in Abilene, Texas, has ... which He does not. Yisrayl says with so many titles and names for the ... he says with a little Scripture, backed with a lot of research, the truth is ...
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... ... skincare and advanced nutraceutical supplements, through its Nova Skin Sciences division, recently ... hydrating benefits of a moisturizer with the power of an anti-aging concentrate. ...
(Date:4/28/2017)... ... 2017 , ... Christie Medical Holdings, Inc. , with its market-leading ... Medical Inc. , a leader in infusion therapy and pain management. , Intravenous ... percent of hospital patients receiving a peripheral IV catheter as part of their treatment ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , Tenn. and DALLAS , April 19, ... Inc., announced that the first patients in ... EndoStim device in the Lower Esophageal Sphincter Stimulation for ... minimally-invasive implantable device designed to provide long-term reflux control ... GERD affects nearly 65 million people in ...
(Date:4/19/2017)... , April 19, 2017  Novartis today announced ... National Heart, Lung, and Blood Institute (NHLBI) of ... 58% of patients with treatment-na├»ve severe aplastic anemia ... treated with eltrombopag at the initiation of and ... study evaluated three sequential treatment groups, or cohorts. ...
(Date:4/18/2017)... 18, 2017 Research and Markets has announced ... report to their offering. ... global arthroscopy devices market to grow at a CAGR of 6.35% ... Devices Market 2017-2021, has been prepared based on an in-depth market ... landscape and its growth prospects over the coming years. The report ...
Breaking Medicine Technology: