Navigation Links
Heart's Stem Cells Not Created Equally
Date:4/14/2008

Progenitor cells may not follow same pathways, researchers say

MONDAY, April 14 (HealthDay News) -- Not all heart cells are created by the same universal signal, a discovery that could lead to future treatments for congenital heart disease and heart attacks, U.S researchers say.

Experiments conducted on frogs challenge long-held beliefs that the stem cells that eventually develop into the heart's muscle tissue do so in reaction to the same cue.

"Not only does it tell us about how stem cells differentiate to create the heart, but it provides us with knowledge that may very well help us to repair heart muscle after a heart attack," researcher Dr. Cam Patterson, director of the Carolina Cardiovascular Biology Center at the University of North Carolina at Chapel Hill, said in a prepared statement.

The study was published online in the April 14 issue of the journal Developmental Cell and in the April 15 print edition.

The researchers manipulated genetic material in frog embryos so their cells would not produce a gene known as CASTOR, which had been linked to stem cell differentiation in the fruit fly.

Without CASTOR present, a small subset of cells at the base of an embryo's heart remained in a state of infancy while others developed. These infant cells, or progenitors, were later found to have developed into the outer walls of the heart's ventricles if they were allowed to progress normally.

This finding affects theories about the possibility of transplanting progenitor cells into the damaged area of the organ, such as heart-attack scarred muscle, in hope of creating healthy tissue. The theory supposes that all progenitors are the same.

"What we have found is that this belief simply isn't true," study senior author Frank Conlon, assistant professor of genetics in the UNC School of Medicine, said in a prepared statement. "Instead, there appear to be at least two types of progenitors, and we think there may be many more."

Conlon is now attempting to manipulate other genes in addition to CASTOR to determine how many types of heart cell progenitors exist. He hopes to verify his findings other animal models before searching for genetic counterparts in humans.

More information

The American Heart Association has more about common cardiovascular diseases.



-- Kevin McKeever



SOURCE: University of North Carolina at Chapel Hill, news release, April 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Healing Wounds and Hearts: Warrior Weekend Helps Soldiers Relax and Recover
2. Lack of Sleep Hurts Womens Hearts Most
3. Caring for Heart Patients Can Strain Hearts
4. Research Shows Alcohol Can Benefit the Hearts of New Drinkers
5. Pacemaker tune-up works chemical wonders on damaged hearts in dogs
6. King of Talk Celebrates Milestone With Quaker, The King of Hearts
7. Free For All on Leap Day to Get Hearts Pumping!
8. Childrens Heart Foundation (CHF) Hosts 4th Annual Arizona Swing For Their Hearts Golf Event
9. Study Finds Women Pay More Attention to Their Hair Than Their Hearts
10. Obesity Can Hurt Kids Hearts
11. Study Shows How Exercise Helps Womens Hearts
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Heart's Stem Cells Not Created Equally
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding emergency ... its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. Ogunleye ... M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. Ogunleye ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... a startling report released today, National Safety Council research ... proven plan to eliminate prescription opioid overdoses. Prescription Nation ... tackling the worst drug crisis in recorded U.S. history, assigned a ... , New Mexico , Tennessee ... failing states, three – Michigan , ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... their offering. The current ... environment for MedImmune to enter. The US ageing population creates ... drive considerable growth for effective anti-influenza medications. The introduction of ... but development is still in its infancy. ...
Breaking Medicine Technology: