Navigation Links
Heartburn treatment may extend survival in IPF patients
Date:7/19/2011

Patients with idiopathic pulmonary fibrosis (IPF) who report treatment for gastroespophageal reflux (GER) appear to have longer survival than IPF patients who are not treated for GERD, according to a new study from the University of California, San Francisco.

"While preliminary, these findings support a relationship between GER, chronic microaspiration and IPF," said lead researcher Joyce Lee, MD, clinical instructor in the Department of Medicine at UCSF. Microaspiration occurs when gastric droplets reflux into the esophagus and enter the airways.

The study was published online ahead of the print edition of the American Thoracic Society's American Journal of Respiratory and Critical care Medicine.

IPF is a devastating and incurable lung disease, characterized by progressive scarring of the lung tissue, which ultimately prevents the lungs from being able to supply the body with adequate oxygen. The median survival time from diagnosis is 2-3 years.

Dr. Lee and colleagues retrospectively identified patients with IPF from two longitudinal cohorts of patients with interstitial lung disease who were seen at either UCSF or the Mayo Clinic in Rochester, Minn., between April 2001 and July 2008. At both clinics, GER symptoms and treatment were recorded and reviewed prospectively by the treating physician. The researchers recorded demographic data, radiologic data of the extent of fibrosis and survival time.

Of 204 patients, they found that symptoms of GER were present in 34 percent, and patient- or physician-reported history of GER was present in 45 percent (as compared with 10 to 20 percent in the population at large). At the time of diagnosis with IPF, about half of patients reported that they were currently being treated for GER with medication. Eleven patients reported having undergone surgical treatment for GER.

Remarkably, Dr. Lee and colleagues found that patients who had undergone or were undergoing treatment for GER had a significantly improved survival time in comparison to those who had not been treated.

"There is controversy among pulmonologists about how aggressively GER should be treated in patients with IPF, given the risks of both surgical and medical treatment," said Dr. Lee. "However, our study showed that the use of these treatments is not only associated with a lesser degree of fibrosis, but also with a longer survival time."

Two previous case series have suggested that treatment for GER stabilizes IPF, but there is disagreement among IPF experts what the significance of GER is in IPF, Dr. Lee said. "Theoretically, one would suspect more airways manifestations and less peripheral lung involvement if GER and microaspiration were involved in the pathogenesis of IPF, but this is something that is not observed in IPF."

Still, she continued, "The most straightforward explanation for our study results is also the most controversial: that the treatment of GER is beneficial to survival in IPF.suppressing the acidity of gastric contents may reduce the injury caused by microaspiration." Reducing the acidity of gastric contents with medication alone does not prevent microaspiration of weakly-acidic reflux, which may explain why Nissen fundoplication, a surgical procedure that reduces both acidic and weakly-acidic GER, appeared to have an additional benefit over medication alone in the study.

"The results of our study need validation to confirm the association between reported GER medication and survival time," said Dr. Lee. "The next step would be a prospective longitudinal cohort of patients with carefully recorded GER-related variables. If our results are validated, future studies should look beyond association and address how the treatment of GER might affect survival in IPF."


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Popular Heartburn Meds May Boost Fracture Risk
2. Scott & White Healthcare -- Round Rock performing surgery without incisions for heartburn
3. Heartburn Drugs May Raise Pneumonia Risk
4. For Most, Chronic Heartburn Not a Big Risk for Esophageal Cancer
5. No Link Between Heartburn Drugs and Birth Defects: Study
6. Heartburn Drugs, Plavix Seem Safe to Take Together
7. Plavix, Heartburn Drug Safe to Take Together: Study
8. FDA Warns of Fracture Risk With Popular Heartburn Drugs
9. Coming Soon: A Low-Heartburn Coffee?
10. Columbia University Medical Center receives $38.9 million to help translate science into treatment
11. Innovations in cardiovascular therapies and treatments will be presented at TCT 2011
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... May 02, 2016 , ... ... announced a new Specialty Pharmacy Patient Satisfaction Award that will recognize specialty pharmacies ... quarterly results from Zitter Health Insights’ Specialty Pharmacy Patient Satisfaction Survey compiled throughout ...
(Date:5/2/2016)... ... May 02, 2016 , ... Visceral fat, also known as ... kidneys, liver and pancreas. If not properly addressed, visceral fat can lead to ... Medicine, Medical Oncology and Palliative Care, warns against the dangers of visceral fat. ...
(Date:5/2/2016)... (PRWEB) , ... May 02, ... ... researchers report that many commonly used prescription medications, including anxiolytics, painkillers, antidepressants ... mitigate these risks, Novus Medical Detox Center —a leading Florida-based drug ...
(Date:5/2/2016)... , ... May 02, 2016 , ... Pregnancy Awareness Month ... trying to conceive. , “If you are ready to have a baby, ... “My book, HealthChequesTM: Journal Babies is your Personal Conception & Pregnancy Organizer, written ...
(Date:5/2/2016)... , ... May 02, 2016 , ... ... and urgent care facilities designed to automate and improve the rapid diagnosis, triage ... it is demonstrating their platform, application, and mobile experience for the first time ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)...   Acsis , a leading provider of supply ... research and advisory firm IDC has named it a ... Pharmaceutical Track and Trace Software 2016 Vendor Assessment (doc ... of the capabilities and business strategies of 10 vendors ... Logo - http://photos.prnewswire.com/prnh/20160427/360791LOGO ...
(Date:4/28/2016)... 2016 New market research ... a report that provides an overview of the ... by identifying new targets and MOAs to produce ... discussed in this H1 2016 Osteoarthritis Pipeline report ... Inc., Abiogen Pharma S.p.A., Ablynx NV, Achelios Therapeutics, ...
(Date:4/27/2016)... 2016   ... sur le trimestre, soutenu par une croissance de ... Croissance de +16% des ventes aux hôpitaux et ... Technologies (Euronext : MKEA, FR0010609263 ; OTCQX : MKEAY), inventeur de ... son chiffre d,affaires pour le premier trimestre clos ...
Breaking Medicine Technology: