Navigation Links
Heartburn Drugs May Raise Fracture Risk in Older Women

By Steven Reinberg
HealthDay Reporter

TUESDAY, Jan. 31 (HealthDay News) -- Older women who take popular medications to control indigestion and heartburn may put themselves at higher risk for hip fractures, researchers report.

Long-term use of these drugs, called proton pump inhibitors (PPIs), may increase that risk by 35 percent to 50 percent for current or former smokers, the researchers added. Prilosec, Nexium and Prevacid are some examples of these medications.

"Although PPI use might be strongly indicated in some patients, at least for short-term use, we believe that clinicians should continue to carefully monitor the need for long-term use of these medications, specifically among postmenopausal women with a history of smoking," said lead researcher Dr. Hamed Khalili, a clinical and research fellow in gastroenterology at Massachusetts General Hospital in Boston.

"Our data supports the recent decision by the U.S. Food and Drug Administration to revise labeling of PPIs to incorporate concerns about a possible increase in risk of fractures with these drugs," he said.

The report was published in the Jan. 31 online edition of the BMJ.

For the study, Khalili's team collected data on almost 80,000 postmenopausal women. Over the course of eight years, from 2000 to 2008, almost 900 hip fractures occurred -- a 35 percent increased risk for women using PPIs compared to women who didn't take the drugs.

In absolute terms, the risk of hip fracture works out to about 2.02 fractures for every 1,000 person years for those taking PPIs, compared with 1.51 fractures per 1,000 person years. Person years are the number of years in a study multiplied by the number of people in the study.

The increased risk of fractures among women who smoked was even higher, reaching 50 percent, they added. The longer a women took a PPI, the more her risk increased, the researchers noted.

In 2000, 6.7 percent of the women used PPIs regularly; by 2008 that had jumped to 18.9 percent. This could mean that more fractures will be seen in years to come, they added.

Women who stopped using PPIs saw their risk of hip fracture return to normal within two years, Khalili's group noted.

In calculating the risk of hip fracture, the researchers tried to account for weight, age, exercise, smoking, calcium in the diet and supplement use.

Dr. Olveen Carrasquillo, chief of general internal medicine at the University of Miami Miller School of Medicine, said that, "I have really been concerned about doctors dispensing too many PPIs and people taking these for life."

"A lot of the time, PPIs are used for things that are controlled better with diet," he said.

PPIs should be given for a few months and then tapered off, Carrasquillo said. "The problem is that if you stop them suddenly you get acid rebound, and patients start having symptoms again, so you need to taper them off the medication slowly," he explained.

Carrasquillo noted that smokers are at higher risk of gastric problems and complications from PPIs. So, quitting smoking is a good start in controlling these issues, he said.

Often, calcium supplements are used to bolster bone strength, but because PPIs affect the absorption of calcium, taking calcium supplements may not be effective, he said. The researchers did take calcium supplement use into account and the risk remained, he added.

"It looks like, even among women who are smokers, taking calcium supplements doesn't seem to make a difference," he said.

There is a small group of patients whose symptoms will persist and for these patients one has to balance the risk of fracture with the benefit of the drug, Carrasquillo said. "But in the vast majority of cases these patients should not be on PPIs," he said.

More information

For more on PPIs, visit the U.S. National Library of Medicine.

SOURCES: Hamed Khalili, M.D., clinical and research fellow, gastroenterology, Massachusetts General Hospital, Boston; Olveen Carrasquillo, M.D., chief, general internal medicine, University of Miami Miller School of Medicine; Jan. 31, 2012, BMJ, online

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Heartburn Meds Wont Help, May Harm Kids With Asthma
2. Chronic Heartburn a Growing Problem in U.S.
3. Heartburn treatment may extend survival in IPF patients
4. Popular Heartburn Meds May Boost Fracture Risk
5. Scott & White Healthcare -- Round Rock performing surgery without incisions for heartburn
6. Heartburn Drugs May Raise Pneumonia Risk
7. For Most, Chronic Heartburn Not a Big Risk for Esophageal Cancer
8. No Link Between Heartburn Drugs and Birth Defects: Study
9. Heartburn Drugs, Plavix Seem Safe to Take Together
10. Plavix, Heartburn Drug Safe to Take Together: Study
11. FDA Warns of Fracture Risk With Popular Heartburn Drugs
Post Your Comments:
Related Image:
Heartburn Drugs May Raise Fracture Risk in Older Women
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing ... which patients and their families pay tribute to a genetic counselor by nominating him ... Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome ...
(Date:6/24/2016)... New York, NY (PRWEB) , ... June 24, ... ... lifestyle publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as ... believes that “the most beautiful women in the world, and the most handsome ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, LLC ... by obtaining investment capital for emerging technology companies. SCP has delivered investment ... resulted in more than a million dollars of capital investment for five companies. ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th ... Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised ... have been wounded in battle and their families. Venture Construction Group is a 2016 ...
(Date:6/24/2016)... Gilbert, Arizona (PRWEB) , ... June 24, 2016 ... ... Gilbert-based practice, is supporting the upcoming 2016 Miss Arizona pageant as its official ... primarily serves Scottsdale, Tempe, Mesa, and Chandler, Arizona. , Dr. Olson says ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June ... -based mobile pulmonary function testing company, is now able to ... devices developed by ndd Medical Technologies , Inc. ... done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ... , can get any needed testing done in the comfort of ...
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ., ... developing innovative inhaled drugs, announced today that it was ... Investments reconstituted its comprehensive set of U.S. and ... "This is an important milestone for Pulmatrix," said Chief ... shareholder awareness of our progress in developing drugs for ...
(Date:6/23/2016)...  MedSource announced today that it has selected ... of choice.  This latest decision demonstrates MedSource,s commitment ... clients by offering a state-of-the-art electronic data capture ... as the EDC platform of choice in exchange ... has long been a preferred EDC platform by ...
Breaking Medicine Technology: