Navigation Links
Heartburn Drugs, Plavix Seem Safe to Take Together
Date:10/7/2010

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, Oct. 6 (HealthDay News) -- Heartburn drugs known as proton-pump inhibitors can safely be taken with the blood thinner Plavix, a new study indicates.

There has been concern that these medications, called PPIs, might interfere with the ability of Plavix (clopidogrel) to do its job.

"This is reassuring data that there is not any clinically significant interaction between clopidogrel and PPIs," said lead researcher Dr. Deepak L. Bhatt, chief of cardiology at the Veterans Affairs Boston Healthcare System.

"This is contrary to prior observational, non-randomized studies that showed that if you took clopidogrel and a PPI, it blunted the ability of clopidogrel to protect from things like heart attack," he noted.

In addition, this is the first randomized clinical trial to show that prophylactic use of PPIs for patients taking Plavix reduces gastrointestinal bleeding, he said.

Doctors often prescribe the two drugs in combination to prevent clotting and reduce the risk of stomach bleeding, which can be a serious complication for patients taking Plavix.

Randomized, double-blind trials that compare outcomes of patients taking a drug or placebo, or another drug are considered the "gold standard" of clinical trials, because they can actually show what patients experience.

In contrast, observational studies use data from patient records or other sources to paint a picture of patient outcomes. Since these data are from past experience, the conclusions of these studies can find associations, but not establish causes of outcomes.

The report is published in the Oct. 6 online edition of the New England Journal of Medicine.

For the study, Bhatt and colleagues randomly assigned 3,873 patients who needed Plavix to Plavix alone or in combination with omeprazole (Prilosec) or a placebo; patients also received aspirin.

Over six months, 51 patients had gastrointestinal bleeding. That was a rate of bleeding of 1.1 percent among those taking Plavix plus Prilosec and 2.9 percent among those taking Plavix and a placebo, the researchers found.

In addition, 109 patients had a heart attack, stroke, died or needed another cardiac procedure. The rate of these events was 4.9 percent among those receiving Prilosec and 5.7 percent among those receiving a placebo, Bhatt's group found.

More patients taking Prilosec had a higher risk of diarrhea, the researchers noted.

The study also had two main limitations, the researchers reported: It was terminated early due when the sponsor, Cogentus Pharmaceuticals, lost financing, and the numbers of participants were not large enough to rule out the possibility of a clinically significant difference in cardiovascular events, such as heart attack, due to the use of a PPI.

However, the study did not find any significant increases in the risk of cardiovascular events, even in high-risk group, the researchers reported.

"This should be quite reassuring to physicians that there isn't a bad interaction to worry about," Bhatt said.

Commenting on the study, Dr. Gregg Fonarow, a professor of cardiology at the University of California, Los Angeles, said that "there have been significant concerns based on observational studies and platelet function testing that proton-pump inhibitors like Prilosec may interfere with the antiplatelet effect of clopidogrel, increasing the risk patients would have cardiovascular events."

"This trial is quite reassuring, with no signal of cardiovascular harm when proton pump inhibitors are given to patients receiving clopidogrel and aspirin," said Fonarow, who was not involved with the study. "Prophylactic use of proton-pump inhibitors may be appropriate in patients at increased risk for gastrointestinal bleeding."

Another expert, Dr. James Brophy, a professor of medicine and epidemiology at the Royal Victoria Hospital in Montreal, said that "much of the problem of earlier research in this area has been observational and therefore subject to potential biases. The present study is a big step forward as it was a randomized study."

This latest finding -- coupled with the fact that other recent studies have not confirmed earlier studies suggesting an increased in adverse cardiac events -- is reassuring, he said.

"For the moment, the data is reassuring that PPIs can be safely prescribed if there is a clinical indication," Brophy said. "The story does seem a prime example of the Proteus phenomena, initially very positive worrisome results generally being proven to be not as extreme as initially feared."

Indeed, a recent Danish study also found that taking Plavix and a PPI together was safe and did not compromise the effects of Plavix.

More information

For more information on the Plavix-PPI combo, visit the U.S. Food and Drug Administration.

SOURCES: Deepak L. Bhatt, M.D., M.P.H., chief, cardiology, Veterans Affairs Boston Healthcare System and Brigham & Women's Hospital, Boston; James Brophy, M.D., Ph.D., professor, medicine and epidemiology, Royal Victoria Hospital, Montreal; Gregg Fonarow, M.D., American Heart Association spokesman and professor, cardiology, University of California, Los Angeles; Oct. 6, 2010, New England Journal of Medicine, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Plavix, Heartburn Drug Safe to Take Together: Study
2. FDA Warns of Fracture Risk With Popular Heartburn Drugs
3. Coming Soon: A Low-Heartburn Coffee?
4. New Data Supports Link Between Diabetes Drugs, Fractures
5. Teen Girls Becoming More Open to Drugs, Alcohol
6. As FDA Eyes Prostate Cancer Drugs, Experts Urge Caution
7. Scientific exchange program promotes collaborative quality standards for drugs, food ingredients
8. New Drugs, Approaches Offer Hope Against Prostate Cancer
9. Double-Dose Plavix Benefits Certain Patients, Study Finds
10. Plavix Can Help Cut Death Risk in Certain Heart Patients
11. Newer Blood Thinner Beats Plavix for Bypass Patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Heartburn Drugs, Plavix  Seem Safe to Take Together
(Date:5/28/2016)... ... May 28, 2016 , ... "Color Grading media can be time ... preset onto their media," said Christina Austin - CEO of Pixel Film Studios. ... and easily add stylish color grades to their footage. A LUT is a Lookup ...
(Date:5/28/2016)... ... ... of the city where’s it’s easy to spot the neon lights of chains serving fast ... diners with a taste for real food. , On May 13, the Best ... urban casual restaurant focusing on dishes made by hand with wholesome, organic ingredients that are ...
(Date:5/27/2016)... ... May 27, 2016 , ... Two director-level employees of Horizon ... to Women and Industry (TWIN) 2016 honorees. The award recognizes businesswomen who excel ... year, Geri Boone, Director of the MLTSS (Managed Long-Term Services and Supports) Program at ...
(Date:5/27/2016)... ... May 27, 2016 , ... With over 60 percent of acute stroke ... a sustainable product to aid in the rehabilitation process has steadily increased. Ekso Bionics ... individuals with hemiplegia due to stroke. , Ekso Bionics has now received clearance from ...
(Date:5/27/2016)... ... May 27, 2016 , ... ... educate the many who are unaware of the plight of aphasia. In collaboration ... within the “Stroke Awareness” campaign. , The link between stroke and aphasia is ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... 27, 2016 Hutchison China ... focused on the highly lucrative global oncology and ... of potential first-in-class or best-in-class tyrosine kinase inhibitor ... with strategic partners. HCM,s profitable Chinese healthcare business ... We expect progress of the mid-to-late-stage pipeline during ...
(Date:5/26/2016)... , May 26, 2016 A ... growth is the emergence of new treatments. Cardax, a ... for osteoarthritis treatment. The therapy is expected to fulfil ... Research UK is conducting studies to develop new treatments ... where the genes involved in osteoarthritis are being investigated, ...
(Date:5/25/2016)... 25, 2016 According to a ... (3D, 2D, 4D), by Therapeutic Area (Oncology, Cosmeceutical/Plastic Surgery), ... (Medical Device Manufacturers, Hospitals/ Clinics) - Forecast to 2021", ... Animation Market for the forecast period of 2016 to ... Million by 2021 from USD 117.3 Million in 2016, ...
Breaking Medicine Technology: