Navigation Links
Heart scientists discover protein that may be 1 cause of heart failure
Date:5/23/2011

Researchers at the Peter Munk Cardiac Centre discovered a protein switch which can trigger a cascade of events leading to heart failure, pointing to a new direction for drug development.

Our research suggests that PINK1 is an important switch that sets off a cascade of events affecting heart cell metabolism, says Dr. Phyllis Billia, principal author, clinician‑scientist and heart failure specialist at the Peter Munk Cardiac Centre. This could be one of the inciting events in the development of heart failure.

The findings, published today in Proceedings of the National Academy of Sciences, show that the absence of a certain protein, PINK1, causes heart cells to produce less energy. This lack of energy causes some heart cells to die, forcing the remaining cells to work harder to keep the heart going. In response to this stress, the heart muscle cells thicken, a condition known as hypertrophy.

Heart failure is the most common cause of hospitalization in North American adults, and over 50,000 are treated for advanced heart failure annually. Transplantation is the only long-term treatment for end-stage heart failure patients and the long wait times for a matching donor organ make it necessary to find other alternatives.

"Heart Failure remains a silent epidemic in North America, except for those who suffer from this devastating disease. Current therapies, while effective, only target the symptoms of heart failure," says Dr. Vivek Rao, co-author of the study and Surgical Director of the Heart Transplant Program at the Peter Munk Cardiac Centre. "The discovery of PINK-1's role in the development of heart failure may lead to novel treatment to prevent heart failure in those at risk. This discovery represents a novel and as yet, untapped mechanism to fight the battle against heart failure."

In the lab, researchers "knocked-out" or genetically removed the PINK1 gene in mice and studied their heart cells under the microscope. They found that although the hearts initially develop normally, they begin to fail after two months, suggesting that PINK1 isn't required for organ development; rather it is crucial for protecting against heart failure.

Until now, research into the PINK1 gene has focused on its links to early-onset Parkinson's disease and certain cancers including esophageal and endometrial. This is the first study to establish its connection to heart disease.

While more research is required to develop potential clinical treatments, this discovery represents a new way of thinking about the involvement of certain proteins in the progression of heart failure.

"We need to learn more about PINK1 and the other proteins it interacts with at the sub-cellular level," says Dr. Billia. "But if we've identified the inciting event that causes the chain of events leading to failure, research and drug development strategies should be focused in this new area of science."


'/>"/>

Contact: Nicole Bodnar
nicole.bodnar@uhn.on.ca
416-340-4636
University Health Network
Source:Eurekalert

Related medicine news :

1. Younger Docs More Likely to Prescribe Drugs for Heart Disease: Study
2. Blood Pressure Drug Helps Those With Mild Heart Failure
3. Sleep Disorder Linked to Heart Rhythm Problems
4. Breakthrough medical food reverses risk of heart disease and diabetes
5. Dietary inorganic nitrate may reduce heart dysfunction caused by powerful anti-cancer drug
6. Standard Heart Drugs Wont Ease Pulmonary Hypertension
7. Extremely obese children have higher prevalence of psoriasis, higher heart disease risk
8. Simple fitness test could predict long-term risk for heart attack, stroke in middle-aged people
9. Dairy consumption does not elevate heart-attack risk, study suggests
10. Politics May Trump Looks, Personality in Matters of the Heart
11. What Protects the Heart May Also Ward Off Kidney Stones
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/25/2017)... ... March 25, 2017 , ... Getting earned media coverage meaningful for Garden ... , All through the year, Garden Media aims to provide material helpful to clients’ ... and pitching client’s key messages to gain coveted media placements, Garden Media ...
(Date:3/24/2017)... ... March 24, 2017 , ... Infectious disease affects billions ... the United States, it’s a threat that is constantly changing and evolving. Mediaplanet's ... and offers strategies for the healthcare community to help decrease the number of ...
(Date:3/24/2017)... , ... March 24, 2017 , ... The iaedp Foundation, ... other medical professionals caring for those suffering from the full spectrum of disordered eating, ... as eating disorders professionals from nearly all 50 states and several countries converged on ...
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... Assili, announce that they are now offering treatments for sleep apnea and TMJ ... dental offices. Sleep apnea , specifically the obstructive type, is increasingly being ...
(Date:3/24/2017)... , ... March 24, 2017 , ... ... year of enhancements, upgrading their training and leads programs. , In February, 2017, ... for elite sales agents, Performance Partners is designed to teach how to maximize ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... , Mar. 23, 2017 Research and Markets ... Market: Analysis By Procedure, Replacement Procedure By Technique, Repair Procedure By ... ... Valve Devices Market is forecasted to grow at a CAGR of ... devices is driven by rising aging population, growth in population with ...
(Date:3/23/2017)... March 23, 2017 ... created through extensive primary research (inputs from industry ... aims to present the analysis of global heart ... (Replacement and Repair); Replacement Procedure By Technique (Mechanical, ... Technique (Surgical Devices, Balloon Valvuloplasty, Transcatheter Mitral Valve ...
(Date:3/23/2017)... 23, 2017 As a result of ... the prevalence of allergic diseases, cutting edge developments ... revolutionising the ways in which pharmaceutical and biotech ... promises to be both a high quality meeting ... interest groups, immunologists, research scholars and doctors. The ...
Breaking Medicine Technology: