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Heart failure hospitalization more than doubles in IBD flares
Date:5/18/2014

Athens, 18 May 2014: Heart failure hospitalisation more than doubles during inflammatory bowel disease (IBD) flares, according to a study of more than 5 million Danish people. The research was presented today at the Heart Failure Congress 2014, held 17-20 May, in Athens, Greece. The Congress is the main annual meeting of the Heart Failure Association of the European Society of Cardiology.

Dr Sren L. Kristensen, lead author, said: "Previous studies have shown an association between chronic inflammatory diseases (psoriasis, rheumatoid arthritis, systemic lupus erythematosus, celiac disease and IBD) and an increased incidence of venous- and arterial thrombotic disease (primarily heart attack and stroke). Researchers suggest the link is at least in part caused by inflammatory prothrombotic effects."

He added: "However not many studies have investigated whether the risk of heart failure is elevated in patients with these inflammatory diseases, and none at all in patients with IBD. In the present study we aimed to clarify whether IBD patients had an increased risk of heart failure, and secondly whether this risk was correlated to periods of activity or 'flares' in the IBD."

The researchers used a nationwide cohort of 5 436 647 Danish citizens aged 18 years and above with no history of IBD or heart failure. In this study IBD was defined as Crohn's disease and ulcerative colitis. During 1997 to 2011, IBD developed in 23 681 patients, of whom 553 were hospitalised with heart failure during follow-up. Rates of hospitalisation for heart failure were compared between the IBD group and the remaining Danish population, adjusted for age and sex differences.

In patients with new-onset IBD, disease activity (flare, persistent activity, remission) was monitored continuously throughout the study and determined by hospitalisations and prescriptions of glucocorticoids. Flares were defined as a prescription or hospitalisation following a quiescent pe
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Contact: ESC Press Office
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European Society of Cardiology
Source:Eurekalert

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