Navigation Links
Heart drug cuts prostate cancer risk; holds potential for therapeutic use
Date:4/2/2011

Johns Hopkins scientists and their colleagues paired laboratory and epidemiologic data to find that men using the cardiac drug, digoxin, had a 24 percent lower risk for prostate cancer. The scientists say further research about the discovery may lead to use of the drug, or new ones that work the same way, to treat the cancer.

Digoxin, made from the foxglove plant, has been used for centuries in folk medicine and for decades to treat congestive heart failure and heart rhythm abnormalities. It also emerged as a leading candidate among 3,000 drugs screened by the Johns Hopkins team for the drugs' ability to curb prostate cancer cell growth, according to the investigators, who published their findings in the April 3 issue of Cancer Discovery.

Additional research, by the team, in a cohort of more than 47,000 men revealed that those who took digoxin for heart disease had a significantly lower risk of prostate cancer. The scientists cautioned, however, that their work does not prove digoxin prevents prostate cancer nor are they suggesting the drug be used to prevent the disease. "This is not a drug you'd give to healthy people," says Elizabeth Platz, Sc.D., M.P.H., professor of epidemiology, oncology, and urology at the Johns Hopkins Bloomberg School of Public Health. Serious side effects include male breast enlargement and heart rhythm irregularities, and the drug commonly causes nausea, vomiting and headache.

In the first stage of research, Johns Hopkins assistant professor Srinivasan Yegnasubramanian, M.D., Ph.D, Kimmel Cancer Center director and professor William G. Nelson, M.D., Ph.D., and professor Jun Liu, Ph.D., identified 38 compounds already FDA-approved or with a history of medical use out of a database of more than 3,000. The 38 candidate drugs reduced prostate cancer cell growth in the laboratory by at least 50 percent. They did not include known chemotherapy drugs among the 38.

Nelson and Yegnasubramanian then took the list of 38 drugs to Platz, a prostate cancer research collaborator. "They literally burst into my office and asked, 'Can you look at this list of drug candidates and see if you can study any of them in an epidemiologic cohort?'" recalls Platz.

"We realized that combining our laboratory and epidemiologic approaches could reduce the possibility that results on the candidate drugs might be due to chance," says Platz. "Adding the epidemiology study to the drug screen step provided an assessment of the drug's potential activity in people."

The top hit on the list of anti-prostate cancer drugs, disulfiram, is used to treat chronic alcoholism, but because it is rarely used among the general population, it could not be evaluated effectively in the epidemiologic study. The second candidate was digoxin, they report, which was prescribed often enough to be studied.

To see if they could identify a link between digoxin and prostate cancer in humans, they turned to a cohort of about 47,000 men aged 40-75 who participated in Harvard's Health Professionals Follow-up Study from 1986 through 2006 and did not have a cancer diagnosis before 1986. Study participants had completed a questionnaire every two years, reporting on demographic information, medical history, medication use and lifestyle factors. For men who reported a prostate cancer diagnosis, researchers evaluated their medical records and pathology reports.

Among the study participants, 5,002 cases of prostate cancer were reported. Two percent of all study participants reported regular use of digoxin at the beginning of the study, and those men had a 24 percent lower relative risk of getting prostate cancer compared with men who did not use the drug. Those who used digoxin for more than 10 years had about half the risk of developing prostate cancer as those who did not.

Even after ruling out such potentially "confounding factors" as PSA screening, family history of prostate cancer, and use of other heart drugs, the lower risk of prostate cancer among digoxin users held up, the researchers say.

Platz and Yegnasubramanian say that the next steps will be to determine the mechanism of digoxin's effect on prostate cancer cells, which will support testing digoxin or other drugs that work in the same way in clinical trials as a potential prostate cancer therapy. Digoxin alters enzymatic pathways for sodium and potassium in heart cells, and according to the researchers, may also have an effect on the same or different pathways in prostate cancer.


'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Related medicine news :

1. Laughter Not Only Feels Good, Its Good for the Heart
2. Study suggests a relationship between migraine headaches in children and a common heart defect
3. Risks May Rise With Need for Nursing Care After Heart Failure
4. Cost of heart drugs makes patients skip pills, putting themselves at risk
5. Conflicts of Interest Cloud Heart Treatment Guidelines: Study
6. Healthy Lifestyles Could Halve Cases of Dangerous Irregular Heartbeat
7. Dark Chocolate May Harbor Benefits for the Heart
8. Americans Exposure to Mercury From Fish Wont Harm Hearts: Study
9. Outcomes improved by longer delays between heart attacks and elective surgeries
10. Study: Infrequent Sex Can Raise Risk of Heart Attack, Death
11. Do all student athletes need heart screenings?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... February 10, 2016 , ... Western University ... health services to the developmentally disabled in the Coachella Valley. , The two ... new facility at 71-949 Highway 111, Suite 100-B, in Rancho Mirage, California. The ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... and Video Remote Interpreting (VRI) within Healthcare, recently partnered with Heart City ... interpreting (VRI). , For nearly 23 years, Heart City Health Center has provided ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... charity program created to assist the local community. Pledging to select a new ... nonprofit organizations in the area. Their goal is to bring community awareness to ...
(Date:2/10/2016)... , ... February 10, 2016 , ... ... announces that his office is now offering a variety of comprehensive procedures for ... enhancement, eyebrow lift, facial volume restoration, lip enhancement and nasal reshaping. , ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... will bring together more than 200 of the country’s top healthcare executives to ... , “The true benefit of the Forum is the provider-centric perspective, experience, expertise ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 11, 2016 PLAD, Inc. (OTC Pink: PLAD) is ... sales exceeding company targets, are adding key personnel to ... from the United States Patent and Trademark Office for ... Executive Officer of PLAD, Inc.  In January, PLAD established ... with two new customers, Cumberland Goodwill EMS ...
(Date:2/11/2016)... February 11, 2016 F ast ... answers at the ... provider of scientific, technical and medical information products and services, has launched ... peer reviewed clinical information via a mobile device. Elsevier designed the mobile ... Nursing. The new app is available in Android and ...
(Date:2/11/2016)... Ohio , Feb. 11, 2016  Community pharmacists ... increasing efficiency for the pharmacy through a custom-built medication ... Schieber , pharmacist and owner at Schieber Family ... "We can get a lot of patients enrolled in ... for everybody. It,s a win for the patient, and ...
Breaking Medicine Technology: