Navigation Links
Heart Risks Emerging in People With HIV

The virus, medications, or both might be the culprit, experts say

THURSDAY, June 19 (HealthDay News) -- Drugs that suppress HIV are keeping infected individuals alive and relatively healthy for years, even decades. But studies suggest that a new health risk is emerging for these long-term survivors: increased odds for heart attack and stroke.

It's not clear whether the cause is the virus itself or the drugs used to treat it, said Dr. Steven Grinspoon, professor of medicine at Harvard University.

The exact cause of heightened heart risk among HIV patients "may not be just one or the other," he said. "Both may act, in different ways. The drugs may be causing metabolic problems such as dyslipidemia in the traditional way, while the virus can cause inflammation, which is a known factor in atherosclerosis."

Dyslipidemia is an abnormal increase in levels of blood fats such as cholesterol. Having HIV is associated with low levels of "good" HDL cholesterol and high levels of the blood fats called triglycerides, experts have noted.

And studies have shown that HIV drug therapy can cause abnormal accumulations of fat around the organs deep in the abdomen. The U.S. Food and Drug Administration said in March that it was studying the possibility of label changes for two HIV drugs, Ziagen and Videx, because studies showed a higher rate of heart attacks among people taking them.

Whatever the cause, studies, including one led by Grinspoon, show that living with HIV increases the risk of cardiovascular disease by about 70 percent, he said.

"The relative risk is higher for women than for men," Grinspoon said. "It also increases with increasing age. A lot of HIV people are young, so the absolute rates are low, because they are young."

Grinspoon is co-chair of a meeting on HIV and cardiovascular risk, the conclusions of which are reported in both Circulation and the Journal of Acquired Immune Deficiency Syndrome.

"A lot of the studies so far have concentrated on medications," noted Dr. Priscilla Hsue, a cardiologist who is assistant professor of medicine at the University of California, San Francisco, and a member of the group preparing the report. "We've just begun to realize that the virus itself might be responsible. It affects the immune system and results in chronic inflammation, and both have effects on the cardiovascular system."

In terms of prevention, there should be an emphasis on well-known risk factors such as high blood pressure, obesity and smoking, Grinspoon and Hsue said. "We concentrate on smoking, because a lot of [patients with HIV] smoke cigarettes," she said. "But we must work on all the primary risk factors -- weight loss for obesity, family history, diabetes."

One important priority is to develop a cardiovascular risk factor profile that is specific for people infected with HIV, according to Grinspoon.

In terms of primary prevention of heart trouble, Hsue is a strong advocate for the use of daily aspirin. "It is really cheap and very effective at reducing heart attack and stroke," she said.

Close attention to risk factors is one part of "a two-prong approach," the other prong being development of more effective anti-HIV drugs, Grinspoon added. "The drug companies should develop medications with less side effects," he said.

But it is important for HIV-infected individuals to keep taking their HIV-suppressing drugs, he said. At least one study has shown a higher risk for people who went off and then back on HIV therapy, Grinspoon noted.

"It is definitely better to take your HIV medication," he said. "It is very positive. It saves lives."

More information

Find out more on treating HIV infection at the U.S. Department of Health and Human Services.

SOURCES: Steven Grinspoon, M.D., professor, medicine, Harvard Medical School, Boston; Priscilla Hsue, M.D., assistant professor, medicine, University of California, San Francisco; June, 2008, Circulation, Journal of Acquired Immune Deficiency Syndrome

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. First gene therapy for heart failure offered at NewYork-Presbyterian/Columbia
2. SCAI Creates New Council for Rising Interest in Interventional Therapies for Structural Heart Disease
3. People With Lower Incomes, Lower Education Levels Have Higher Death Rates After Experiencing Heart Attack
4. American Heart Associations 3rd new journal -- Circulation: Cardiovascular Imaging
5. American Heart Associations Third New Journal - Circulation: Cardiovascular Imaging - Set for July Launch
6. Less Intensive Treatment Given Diabetic Women With Heart Disease
7. U.S. Preventive Medicine Experts Available to Discuss Role of Prevention in Avoiding Heart Attacks
8. American Heart Association Extends Sympathy to Family of Journalist Tim Russert
9. Chinese Red Yeast Rice May Prevent Heart Attack
10. Lifestyle Counseling Reduces Heart Risk
11. WorldHeart Announces Voluntary Delisting from the Toronto Stock Exchange
Post Your Comments:
Related Image:
Heart Risks Emerging in People With HIV
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the ... Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , “We ... new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of ... of the latter, setting the bar too high can result in disappointment, perhaps even ... progress toward their goal. , Research from reveals that behind ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... ... 2016 , ... Comfort Keepers® of San Diego, CA is excited to announce ... program to drive cancer patients to and from their cancer treatments. Comfort Keepers ... of life and ongoing independence. Getting to and from medical treatments is one ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute ... Dr. Barry M. Weintraub as a prominent plastic surgeon and the network’s newest ... world, and the most handsome men, look naturally attractive. Plastic surgery should be ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced ... as its e-clinical software solution of choice.  This ... best possible value to their clients by offering ... The preferred relationship establishes nowEDC as the EDC ... for MedSource,s full-service clients.  "nowEDC has long been ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that it ... (procalcitonin) assay as a dedicated testing solution for people ... Roche is the first IVD company in the U.S ... assessment and management. PCT is a sepsis-specific ... blood can aid clinicians in assessing the risk of ...
Breaking Medicine Technology: