WEDNESDAY, Nov. 28 (HealthDay News) -- The widely used heart drug digoxin is associated with an increased risk of death in people with the common heart rhythm disorder know as atrial fibrillation, a new study finds.
Researchers analyzed data from more than 4,000 patients with atrial fibrillation and found that digoxin was associated with a 41 percent increased risk of death from all causes, a 35 percent increased risk of death from cardiovascular causes, and a 61 percent increased risk of death from problems with the rate and rhythm of the heartbeat.
The findings mean that among patients with atrial fibrillation who take taking digoxin -- compared to those not taking digoxin -- one additional patient out of six will die from any cause over five years, one additional patient out of eight will die from cardiovascular causes, and one additional patient out of 16 will die from arrhythmias, the study authors said.
The study, led by Samy Claude Elayi, an associate professor of medicine at the Gill Heart Institute at the University of Kentucky, was published online Nov. 28 in the European Heart Journal.
Digoxin is found naturally in the foxglove plant, from which it is extracted. The drug helps the heart beat more strongly and with a more regular rhythm and is commonly used in both atrial fibrillation patients and heart failure patients. However, while the use of digoxin has been widely studied in heart failure patients, there's been a lack of data about its use in patients with the irregular heartbeat, according to the study authors.
They said their findings call into the question the widespread use of digoxin in atrial fibrillation patients.
"These findings mean that physicians should try to control a patient's heart rate by using alternatives as a first line, such as beta-blockers or calcium blockers; if digoxin is used, use a low dose with careful clinical follow-up, evaluate potential drug inter
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