Navigation Links
Heart Drug Combos Raise Risk of Gastrointestinal Bleeding
Date:6/2/2009

Specialists should consider risks vs. benefits, researcher says

TUESDAY, June 2 (HealthDay News) -- Common drug combinations used to treat heart disease raise the risk of bleeding or perforation of the upper gastrointestinal tract, new research shows.

Researchers examined data on 78,084 patients aged 60 to 99 from a Department of Veterans Affairs national pharmacy and administrative database. About 30 percent were prescribed what is known as Complex Antithrombotic Therapy, combinations of two or three drugs, between January 2003 and September 2006.

The combinations include anticoagulant-antiplatelet (ACAP), aspirin-antiplatelet (ASAP), aspirin-anticoagulant (ASAC) or TRIP (aspirin-anticoagulant-antiplatelet).

The drugs are typically prescribed to treat people with a history of heart attack, stroke or peripheral vascular disease.

Within one year of starting the drugs, 1,061 experienced an upper gastrointestinal (GI) event, such as bleeding or perforation, requiring immediate medical attention. The upper GI tract includes the pharynx, esophagus and stomach.

Patients prescribed ASAP and ASAC drug combinations were two and a half times more likely to suffer an upper gastrointestinal event than those not taking the drugs. The fewest upper GI problems occurred among people taking ACAP.

The greatest risk came from TRIP, which correlated with a fourfold increased risk of an upper GI event, according to the study to be presented Tuesday at Digestive Disease Week 2009 in Chicago.

Younger patients -- those between 60 and 69 years old -- were at the highest risk. That age group was most likely to take the TRIP drug-combo because of a likelier history of ischemic heart disease, hypertension, diabetes and peripheral artery disease, the study found.

"The fact that triple therapy is most commonly prescribed to younger patients reflects the changes in current cardiac care," study author Dr. Neena S. Abraham, of the Michael E. DeBakey VA Medical Center and Baylor College of Medicine in Houston, said in a Digestive Disease Week news release. "The observed magnitude of UGIE [upper gastrointestinal event] risk suggests an unfavorable risk/benefit profile for CAT [Complex Antithrombotic Therapy] in the short term."

Gastroenterologists and cardiologists need to further evaluate the risk-benefit ratio of these therapies given the twofold to fourfold increased UGIE risk, Abraham said.

More information

The National Digestive Diseases Information Clearinghouse has more on digestive tract bleeding.



-- Jennifer Thomas



SOURCE: Digestive Disease Week, news release, June 2, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Drug for cluster headaches may cause heart problems
2. Use of certain lipid measures not more effective in predicting coronary heart disease
3. Restricting Blood Flow May Help Heart Bypass Patients
4. Urban Smog Tough on Young Adults Hearts
5. Stanford study highlights cost-effective method of lowering heart disease risks
6. Vitamin Es lack of heart benefit linked to dosage
7. Drug That Lowers Resting Heart Rate Being Tested
8. Heart Attack Boosts Diabetes Risk
9. Embryonic Stem Cells Repair Human Heart
10. U of M study: Early treatment can reverse heart damage
11. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Heart Drug Combos Raise Risk of Gastrointestinal Bleeding
(Date:4/28/2017)... ... ... Intellitec Solutions announced the publication of a case study ... solution that integrates to their PointClickCare EHR software package. With the guidance of ... now has the capability to achieve its goal for a comprehensive EHR solution, ...
(Date:4/28/2017)... ... April 28, 2017 , ... Semrock’s highly popular SearchLight ... online modeling resource for fluorescence microscopists and optical system designers, enabling The Right ... years spanning the globe, SearchLight has become a tremendously popular tool for the ...
(Date:4/27/2017)... (PRWEB) , ... April 27, 2017 , ... Healthcare companies ... But they will rapidly reject an outdated healthcare executive resume. , “If you’re a ... at your executive resume and wondering if it’s as ready as you are for ...
(Date:4/27/2017)... ... April 27, 2017 , ... SyncDog, ... sponsorship at MobileIron Live! 2017 in Santa Clara, California. Each year, ... educational approach to helping organizations maximize the benefits of mobility in their operations ...
(Date:4/27/2017)... ... April 27, 2017 , ... Plastic Surgery Associates is excited to ... to present at the upcoming Aesthetic Meeting. Held in San Diego, at the San ... and Canales will lend their expertise to the Premier Global Hot Topics session, speaking ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... Corporation (TSX: CRH) (NYSE MKT: CRHM) (the "Company"), announces that it will ... at the Sheraton Hotel in Toronto, Ontario . ... Company is scheduled to present on Tuesday, May 2 at 10:00 ... of the Board, Tony Holler will also attend the ... For more details about ...
(Date:4/19/2017)... April 19, 2017 Global Prostate Cancer ... on the prostate cancer therapeutics market analyzes the ... Increasing prevalence of prostate cancer, launch of promising ... development of new drugs & therapeutic biological products, ... due to lesser side effects are some of ...
(Date:4/19/2017)... BOSTON , April 19, 2017  New research provides ... with advanced Parkinson,s, according to a study released today that ... 69th Annual Meeting in Boston , ... comes to the treatment of Parkinson,s disease, the oral drug ... of life and longevity. But as the disease progresses, the ...
Breaking Medicine Technology: