Navigation Links
Heart Drug Combos Raise Risk of Gastrointestinal Bleeding

Specialists should consider risks vs. benefits, researcher says

TUESDAY, June 2 (HealthDay News) -- Common drug combinations used to treat heart disease raise the risk of bleeding or perforation of the upper gastrointestinal tract, new research shows.

Researchers examined data on 78,084 patients aged 60 to 99 from a Department of Veterans Affairs national pharmacy and administrative database. About 30 percent were prescribed what is known as Complex Antithrombotic Therapy, combinations of two or three drugs, between January 2003 and September 2006.

The combinations include anticoagulant-antiplatelet (ACAP), aspirin-antiplatelet (ASAP), aspirin-anticoagulant (ASAC) or TRIP (aspirin-anticoagulant-antiplatelet).

The drugs are typically prescribed to treat people with a history of heart attack, stroke or peripheral vascular disease.

Within one year of starting the drugs, 1,061 experienced an upper gastrointestinal (GI) event, such as bleeding or perforation, requiring immediate medical attention. The upper GI tract includes the pharynx, esophagus and stomach.

Patients prescribed ASAP and ASAC drug combinations were two and a half times more likely to suffer an upper gastrointestinal event than those not taking the drugs. The fewest upper GI problems occurred among people taking ACAP.

The greatest risk came from TRIP, which correlated with a fourfold increased risk of an upper GI event, according to the study to be presented Tuesday at Digestive Disease Week 2009 in Chicago.

Younger patients -- those between 60 and 69 years old -- were at the highest risk. That age group was most likely to take the TRIP drug-combo because of a likelier history of ischemic heart disease, hypertension, diabetes and peripheral artery disease, the study found.

"The fact that triple therapy is most commonly prescribed to younger patients reflects the changes in current cardiac care," study author Dr. Neena S. Abraham, of the Michael E. DeBakey VA Medical Center and Baylor College of Medicine in Houston, said in a Digestive Disease Week news release. "The observed magnitude of UGIE [upper gastrointestinal event] risk suggests an unfavorable risk/benefit profile for CAT [Complex Antithrombotic Therapy] in the short term."

Gastroenterologists and cardiologists need to further evaluate the risk-benefit ratio of these therapies given the twofold to fourfold increased UGIE risk, Abraham said.

More information

The National Digestive Diseases Information Clearinghouse has more on digestive tract bleeding.

-- Jennifer Thomas

SOURCE: Digestive Disease Week, news release, June 2, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Drug for cluster headaches may cause heart problems
2. Use of certain lipid measures not more effective in predicting coronary heart disease
3. Restricting Blood Flow May Help Heart Bypass Patients
4. Urban Smog Tough on Young Adults Hearts
5. Stanford study highlights cost-effective method of lowering heart disease risks
6. Vitamin Es lack of heart benefit linked to dosage
7. Drug That Lowers Resting Heart Rate Being Tested
8. Heart Attack Boosts Diabetes Risk
9. Embryonic Stem Cells Repair Human Heart
10. U of M study: Early treatment can reverse heart damage
11. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
Post Your Comments:
Related Image:
Heart Drug Combos Raise Risk of Gastrointestinal Bleeding
(Date:11/26/2015)... ... November 26, 2015 , ... Inevitably when people think ... customers choose to buy during the Black Friday and Cyber Monday massage chair ... to search the Internet high and low to find the best massage chair deals, ...
(Date:11/26/2015)... ... 26, 2015 , ... PRMA Plastic Surgery is updating their record books yet ... 6,000th free flap breast reconstruction surgery! , “What an accomplishment for the PRMA team, ... lives and it’s an honor to have served all of these women.” , PRMA ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... more aggressive than those found on mammography, according to a study published online ... additional cancers not seen on mammography may necessitate a change in treatment. , ...
(Date:11/25/2015)... ... November 25, 2015 , ... TyloHelo Inc , ... accessories. , Sauna accessories help improve the bather experience in the sauna, and ... styles for the purist looking for simplicity in design to accessories that encourage ...
(Date:11/25/2015)... ... November 25, 2015 , ... According to an ... is being more and more widely heralded as a breakthrough for performing hernia repairs. ... has over traditional laparoscopic surgery is that it can greatly reduce the pain that ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... of the "2016 Future Horizons and ... Abuse Testing Market: Supplier Shares, Country Segment ... to their offering. --> ... "2016 Future Horizons and Growth Strategies ...
(Date:11/26/2015)... PUNE, India , November 26, ... --> --> ... Research Report" and "Investigation Report on ... 2019 and 2021 forecasts data and ... library. . ...
(Date:11/26/2015)... November 26, 2015 ... addition of the  "2016 Future Horizons ... Cell Surface Marker Testing Market: Supplier ... to their offering.  --> ... of the  "2016 Future Horizons and ...
Breaking Medicine Technology: