Navigation Links
Heart Drug Combos Raise Risk of Gastrointestinal Bleeding
Date:6/2/2009

Specialists should consider risks vs. benefits, researcher says

TUESDAY, June 2 (HealthDay News) -- Common drug combinations used to treat heart disease raise the risk of bleeding or perforation of the upper gastrointestinal tract, new research shows.

Researchers examined data on 78,084 patients aged 60 to 99 from a Department of Veterans Affairs national pharmacy and administrative database. About 30 percent were prescribed what is known as Complex Antithrombotic Therapy, combinations of two or three drugs, between January 2003 and September 2006.

The combinations include anticoagulant-antiplatelet (ACAP), aspirin-antiplatelet (ASAP), aspirin-anticoagulant (ASAC) or TRIP (aspirin-anticoagulant-antiplatelet).

The drugs are typically prescribed to treat people with a history of heart attack, stroke or peripheral vascular disease.

Within one year of starting the drugs, 1,061 experienced an upper gastrointestinal (GI) event, such as bleeding or perforation, requiring immediate medical attention. The upper GI tract includes the pharynx, esophagus and stomach.

Patients prescribed ASAP and ASAC drug combinations were two and a half times more likely to suffer an upper gastrointestinal event than those not taking the drugs. The fewest upper GI problems occurred among people taking ACAP.

The greatest risk came from TRIP, which correlated with a fourfold increased risk of an upper GI event, according to the study to be presented Tuesday at Digestive Disease Week 2009 in Chicago.

Younger patients -- those between 60 and 69 years old -- were at the highest risk. That age group was most likely to take the TRIP drug-combo because of a likelier history of ischemic heart disease, hypertension, diabetes and peripheral artery disease, the study found.

"The fact that triple therapy is most commonly prescribed to younger patients reflects the changes in current cardiac care," study author Dr. Neena S. Abraham, of the Michael E. DeBakey VA Medical Center and Baylor College of Medicine in Houston, said in a Digestive Disease Week news release. "The observed magnitude of UGIE [upper gastrointestinal event] risk suggests an unfavorable risk/benefit profile for CAT [Complex Antithrombotic Therapy] in the short term."

Gastroenterologists and cardiologists need to further evaluate the risk-benefit ratio of these therapies given the twofold to fourfold increased UGIE risk, Abraham said.

More information

The National Digestive Diseases Information Clearinghouse has more on digestive tract bleeding.



-- Jennifer Thomas



SOURCE: Digestive Disease Week, news release, June 2, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Drug for cluster headaches may cause heart problems
2. Use of certain lipid measures not more effective in predicting coronary heart disease
3. Restricting Blood Flow May Help Heart Bypass Patients
4. Urban Smog Tough on Young Adults Hearts
5. Stanford study highlights cost-effective method of lowering heart disease risks
6. Vitamin Es lack of heart benefit linked to dosage
7. Drug That Lowers Resting Heart Rate Being Tested
8. Heart Attack Boosts Diabetes Risk
9. Embryonic Stem Cells Repair Human Heart
10. U of M study: Early treatment can reverse heart damage
11. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Heart Drug Combos Raise Risk of Gastrointestinal Bleeding
(Date:8/18/2017)... , ... August 18, 2017 , ... The Golseth Agency, ... the Dallas/Fort Worth area, is spearheading a regional charity campaign organized to provide support ... In early June of this year, Christina and her children returned from out of ...
(Date:8/18/2017)... ... August 18, 2017 , ... With over 16,000 active ... hormone replacement therapy and integrative medicine, has become a frontrunner for people seeking ... as menopause, andropause, thyroid disorder and adrenal insufficiencies. , Founded in 2003 ...
(Date:8/18/2017)... Boca Raton (PRWEB) , ... August 18, 2017 , ... ... is continuing to ramp up its marketing efforts with its product now available through ... hangover remedy to the public. The effervescent powdered drink is designed to quickly detox ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... ... numbers and call tracking and monitoring solutions, announced today the launch of a ... include a modern navigation and aesthetic, fully responsive design, and an enhanced search ...
(Date:8/18/2017)... ... 18, 2017 , ... “Dangerous Inheritance”: a mystery about saving the family farm. ... from Southwest Nebraska where she was raised on a farm. As Diane wrote ... fictional, but the friendships and mantra of ‘neighbors helping neighbors’ have always been a ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... Aug. 2, 2017 Fenita J. ... as a Pinnacle Lifetime Professional in the Field ... Manager at Turing Pharmaceuticals, AG. Her skills and ... relationship building.                ... 25 years of experience as a highly successful ...
(Date:8/2/2017)... -- Life Flight Network and PeaceHealth Oregon Network announced they renewed ... operational efficiency for patients at hospitals in Eugene ... Grove , and Florence, Oregon , ... Network work collaboratively to move patients who require the highest ... sensitive emergency exists. ...
(Date:8/1/2017)... , Aug. 1, 2017   CerSci Therapeutics , ... Dallas, Texas , has received notice from the ... Institutes of Health (NIH) that it has been awarded ... totaling over $650,000 in 2017 with an additional $1,000,000 ... Investigational New Drug application of their lead non-opioid drug ...
Breaking Medicine Technology: