Navigation Links
Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
Date:5/20/2010

Children with certain variants who were treated with low-dose cancer drug at higher risk, study shows

THURSDAY, May 20 (HealthDay News) -- A new study finds that survivors of childhood cancer with certain genetic variations are more likely than other survivors to develop heart disease.

Researchers say the findings could help them personalize treatment for certain children with cancer to prevent the toxic effects of anthracycline chemotherapy upon the heart.

"Although we depend heavily on anthracyclines for treating children with cancer, we are fully aware of their toxic effects to the heart. We also know that some patients -- despite being exposed to higher doses -- don't develop heart problems, while others with little exposure have considerable cardiac damage," said study senior author Dr. Smita Bhatia, professor and chair of the department of population sciences at the City of Hope National Medical Center in Duarte, Calif., in a news release.

"Our results are a good example of how understanding a cancer patient's genetic makeup can help us better tailor individual therapies," Bhatia said.

About eight out of every 10 children with cancer survive, but they may suffer from health problems related to treatment later in life.

The researchers studied 165 childhood cancer survivors who were diagnosed with heart disease between 1996 and 2008, and compared them to a control group of 323 cancer survivors without heart disease. Among the children who had been treated with low doses of anthracyclines, particular genetic variants of the CBR gene boosted the risk of heart disease.

In the future, oncologists may be able to screen for these gene variants and if necessary, to choose a therapy that will not damage the heart.

The study is scheduled to be released June 7 at the American Society of Clinical Oncology annual meeting in Chicago.

More information

Th
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. New research identifies modifiable risk factors for heart disease
2. Magnetic field measurements of the human heart at room temperature
3. Summit Medical Group hosts “Go Red Day” to Raise Awareness of Heart Disease and Stroke
4. Top 10 Ways to Avoid a Heart Attack This Super Bowl
5. Blood Thinner Combos Risky for Heart Attack Patients
6. HeartMath Offers Free Certificates that Celebrate Love and the Heart
7. Texas Health Dallas Launches Screening Program for Female Heart Disease
8. NHLBI funds preclinical tests on devices for infants and children with congenital heart defects
9. Surgery on beating heart thanks to robotic helping hand
10. Renowned Cardiologist Offers Heart Healthy Tips for the Holiday Season
11. American Heart Month Recognized Feb. 1-28, 2010
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... editorial published today in The Lancet Neurology ... consideration the long term neurological problems that repeated ... most common form of sports-related traumatic brain injury ... may include dementia, amyotrophic lateral sclerosis, and other ... is perhaps more concerning, is that even when ...
(Date:7/13/2014)... County, NC (PRWEB) July 13, 2014 ... of its newest location, the Carolinas HealthCare System - ... facility replaces the aged Anson Community Hospital in Wadesboro. ... is approximately three miles from the previous facility. Situated ... single-story floorplan that includes an emergency room drop-off, helipad, ...
(Date:7/13/2014)... type-1 diabetes could improve patient care worldwide and ... the device,s inventors at the Stanford University School ... be published online July 13 in Nature ... type-1 diabetes outside hospital settings. The handheld microchips ... mellitus, which are both characterized by high blood-sugar ...
(Date:7/13/2014)... Victorian Hotel has recently announced that it ... bikes for its "Cycle the City" program, which encourages ... the area using a rental bicycle, available for just ... call Vancouver home, as it is a city with ... journeys through the countryside. Vancouver hotel rooms often play ...
(Date:7/13/2014)... 2014 The report “Micronutrient Market ... Form (Chelated & Non Chelated), Application Mode (Soil, ... Trends and Forecast to 2018” defines and segments ... and forecasting of the global value and volume ... and restraining factors for the global agriculture micronutrients ...
Breaking Medicine News(10 mins):Health News:Carolinas HealthCare System - Anson Hospital Now Open 2Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 2Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 3Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 4Health News:Victorian Hotel Creates Excitement by Adding "Cycle the City" Bike Rentals for Its Vancouver Hotel Rooms 2Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 2Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 3Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 4
... Amanda Gardner HealthDay Reporter , MONDAY, Feb. 21 (HealthDay ... the early morning hours. Now a new study finds that blood ... as heart attacks -- also follow a circadian pattern and peak ... also found that this type of blood clot, known as stent ...
... February 21 in the Journal of Experimental Medicine ... tumor-promoting inflammation in pancreatic and breast tumors. ... for exampleeach classified according to the proteins, or cytokines, ... produce Th2 cytokines, which some studies suggest drive tumor ...
... News) -- Too often surgical breast biopsies, and not less ... who have abnormal mammograms, a new study says. The ... online in the American Journal of Surgery , said ... 10 percent, 30 percent of the breast biopsies studied between ...
... that sunbathing increases the risk of skin cancer and that ... of melanoma. New research published in BioMed Central,s open access ... in this ,at risk, group are still ignoring sun safety ... and Control Program, New Jersey, asked over 500 people with ...
... body and shake hands with yourself, gain an extra limb ... Henrik Ehrsson has demonstrated that the brain,s image of the ... and virtual worlds. Ask a child if their ... But how does the brain actually identify its own body? ...
... SUNDAY, Feb. 20 (HealthDay News) -- Having "Jack Frost nipping ... it, but frostnip and frostbite can be serious cold weather ... to narrow and constrict, reducing blood flow to the ears, ... and feet, while shifting blood flow to the vital organs. ...
Cached Medicine News:Health News:Clots in Coronary Stents More Likely in Early Morning 2Health News:Clots in Coronary Stents More Likely in Early Morning 3Health News:Study Finds Too Many Surgical Breast Biopsies Performed 2Health News:Study Finds Too Many Surgical Breast Biopsies Performed 3Health News:How to leave your body 2Health News:Frostnip, Frostbite Can Take the Fun Out of Winter 2
(Date:7/10/2014)... July 10, 2014   LabStyle Innovations Corp ... today announced the appointment of Professor Richard ... its Board of Directors. Prof. Stone ... experience to LabStyle as an entrepreneur, venture capitalist ... corporate governance expert. He currently serves on the ...
(Date:1/15/2014)... , Jan. 15, 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com adds ... its store . (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ... upgrade and policy support, China,s ... years, with total market size rising from 3.28 billion ...
(Date:1/15/2014)... Foundation today announced it has established a relief fund ... weather that has gripped much of the nation. AARP and ... to support these emergency relief efforts AARP and AARP Foundation ... up to $500,000 in aid. The matching program will be ...
Breaking Medicine Technology:LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 4Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3
... Letter – recognized since 1959 as the most trusted ... launch of its new blog: More@MedLetter | The official ... found at blog.medicalletter.org . "The Medical ... analysis of the issues reported in our publications or ...
... N.C., May 30, 2012 DebMed ®, creator ... system based on the World Health Organization,s (WHO,s) Five ... system and several new product innovations at the upcoming ... in San Antonio, June 4-6. Product ...
Cached Medicine Technology:DebMed® to Debut Benefits of World's First Electronic Hand Hygiene Compliance Monitoring System Using the WHO Five Moments at Annual Infection Control Conference 2DebMed® to Debut Benefits of World's First Electronic Hand Hygiene Compliance Monitoring System Using the WHO Five Moments at Annual Infection Control Conference 3
A charge capture solution for physicians. Use your handheld to track hospital and ambulatory charges....
... MD Coder Web Edition, gives the Physician, ... access to the MD Coder Web Edition ... the functionality and features of the Enterprise ... behind. Software training, maintenance, upgrades and white ...
A Palm Pilot and Desktop utility that you can use. Search for ICD codes in your office on your computer or in the field using your Palm Pilot....
ZapBill is program that tracks time and anesthesia units. It also automatically determines the proper anesthesia procedure code from the surgical procedure code using a "cross-walk" table....
Medicine Products: