Navigation Links
Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
Date:5/20/2010

Children with certain variants who were treated with low-dose cancer drug at higher risk, study shows

THURSDAY, May 20 (HealthDay News) -- A new study finds that survivors of childhood cancer with certain genetic variations are more likely than other survivors to develop heart disease.

Researchers say the findings could help them personalize treatment for certain children with cancer to prevent the toxic effects of anthracycline chemotherapy upon the heart.

"Although we depend heavily on anthracyclines for treating children with cancer, we are fully aware of their toxic effects to the heart. We also know that some patients -- despite being exposed to higher doses -- don't develop heart problems, while others with little exposure have considerable cardiac damage," said study senior author Dr. Smita Bhatia, professor and chair of the department of population sciences at the City of Hope National Medical Center in Duarte, Calif., in a news release.

"Our results are a good example of how understanding a cancer patient's genetic makeup can help us better tailor individual therapies," Bhatia said.

About eight out of every 10 children with cancer survive, but they may suffer from health problems related to treatment later in life.

The researchers studied 165 childhood cancer survivors who were diagnosed with heart disease between 1996 and 2008, and compared them to a control group of 323 cancer survivors without heart disease. Among the children who had been treated with low doses of anthracyclines, particular genetic variants of the CBR gene boosted the risk of heart disease.

In the future, oncologists may be able to screen for these gene variants and if necessary, to choose a therapy that will not damage the heart.

The study is scheduled to be released June 7 at the American Society of Clinical Oncology annual meeting in Chicago.

More information

The U.S. National Library of Medicine has more on childhood cancer.



-- Randy Dotinga



SOURCE: American Society of Clinical Oncology, May 20, 2010, press release.


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New research identifies modifiable risk factors for heart disease
2. Magnetic field measurements of the human heart at room temperature
3. Summit Medical Group hosts “Go Red Day” to Raise Awareness of Heart Disease and Stroke
4. Top 10 Ways to Avoid a Heart Attack This Super Bowl
5. Blood Thinner Combos Risky for Heart Attack Patients
6. HeartMath Offers Free Certificates that Celebrate Love and the Heart
7. Texas Health Dallas Launches Screening Program for Female Heart Disease
8. NHLBI funds preclinical tests on devices for infants and children with congenital heart defects
9. Surgery on beating heart thanks to robotic helping hand
10. Renowned Cardiologist Offers Heart Healthy Tips for the Holiday Season
11. American Heart Month Recognized Feb. 1-28, 2010
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... Apple Rehab Shelton Lakes , which specializes in the delivery ... as part of a disaster drill on October 3rd. , Apple Rehab participated with ... Manager, as well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer ... one of the most popular and least understood books in the Holy Scriptures, Revelation. ... descriptions that have baffled scholars for centuries. Many have tossed it off as mere ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... services for healthcare compliance program management, will showcase a range of technology and ... for Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) will ... during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual ... F. Collen, a pioneer in the field of medical informatics, this prestigious award is ...
(Date:10/12/2017)... ... ... Leading pediatric oncology experts at Children’s National Health System will ... the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by Jeffrey ... Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of the Division ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., a ... design, and immune-engineering today announced the launch of ... development of personalized therapeutic cancer vaccines. EpiVax has ... exclusive access to enabling technologies to the new ... will lead EpiVax Oncology as Chief Executive Officer. ...
(Date:9/22/2017)... Sept. 22, 2017  As the latest Obamacare repeal ... Bill Cassidy (R-LA) and Lindsey Graham ... the medical device industry is in an odd place. ... the 2.3% excise tax on medical device sales passed ... want covered patients, increased visits and hospital customers with ...
(Date:9/19/2017)... Mich. , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company ... destruction of targeted tissues, announced three leadership team developments today:   ... PhD ... ... Veteran medical device executive Josh ...
Breaking Medicine Technology: