Navigation Links
Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
Date:5/20/2010

Children with certain variants who were treated with low-dose cancer drug at higher risk, study shows

THURSDAY, May 20 (HealthDay News) -- A new study finds that survivors of childhood cancer with certain genetic variations are more likely than other survivors to develop heart disease.

Researchers say the findings could help them personalize treatment for certain children with cancer to prevent the toxic effects of anthracycline chemotherapy upon the heart.

"Although we depend heavily on anthracyclines for treating children with cancer, we are fully aware of their toxic effects to the heart. We also know that some patients -- despite being exposed to higher doses -- don't develop heart problems, while others with little exposure have considerable cardiac damage," said study senior author Dr. Smita Bhatia, professor and chair of the department of population sciences at the City of Hope National Medical Center in Duarte, Calif., in a news release.

"Our results are a good example of how understanding a cancer patient's genetic makeup can help us better tailor individual therapies," Bhatia said.

About eight out of every 10 children with cancer survive, but they may suffer from health problems related to treatment later in life.

The researchers studied 165 childhood cancer survivors who were diagnosed with heart disease between 1996 and 2008, and compared them to a control group of 323 cancer survivors without heart disease. Among the children who had been treated with low doses of anthracyclines, particular genetic variants of the CBR gene boosted the risk of heart disease.

In the future, oncologists may be able to screen for these gene variants and if necessary, to choose a therapy that will not damage the heart.

The study is scheduled to be released June 7 at the American Society of Clinical Oncology annual meeting in Chicago.

More information

Th
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. New research identifies modifiable risk factors for heart disease
2. Magnetic field measurements of the human heart at room temperature
3. Summit Medical Group hosts “Go Red Day” to Raise Awareness of Heart Disease and Stroke
4. Top 10 Ways to Avoid a Heart Attack This Super Bowl
5. Blood Thinner Combos Risky for Heart Attack Patients
6. HeartMath Offers Free Certificates that Celebrate Love and the Heart
7. Texas Health Dallas Launches Screening Program for Female Heart Disease
8. NHLBI funds preclinical tests on devices for infants and children with congenital heart defects
9. Surgery on beating heart thanks to robotic helping hand
10. Renowned Cardiologist Offers Heart Healthy Tips for the Holiday Season
11. American Heart Month Recognized Feb. 1-28, 2010
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... Most people think of donating food around ... overlooked for a variety of reasons—thus making these months ... this need, Dr. Bryne Willey of AlignLife of ... center, wanted to heighten awareness of the need in ... Thanksgiving in July food drive to collect non-perishable foods ...
(Date:8/20/2014)... Los Angeles, CA (PRWEB) August 21, 2014 ... that features in-depth information and reviews of some of ... and many others, is pleased to announce that it ... of the systems. For seniors who are on a ... of medical device, this announcement comes as very welcome ...
(Date:8/20/2014)... 2014 iFitDress.com, the well-known wedding dress ... cheap evening gowns . All items in ... are priced under $100. , iFitDress.com is among ... keeps trying its best to help clients worldwide to ... members are kind and professional. According to its development ...
(Date:8/20/2014)... City, UT (PRWEB) August 20, 2014 ... Benefits Solution, announced the publication of a new ... Zane Benefits, many small business owners feel uncertain ... employees, their family, and their bottom line. , ... comprehensive FAQs, and helps businesses navigate their upcoming ...
(Date:8/20/2014)... By Dennis Thompson ... -- U.S. teen birth rates fell dramatically during the past ... dollars, a new government report shows. An estimated 4 ... the decline, according to researchers from the U.S. Centers for ... "leapt out at me from the report," said Bill Albert, ...
Breaking Medicine News(10 mins):Health News:AlignLife Springfield Office Donates 565 Canned Goods to Springfield Food Pantry 2Health News:Medical Alert Systems Website Now Offering Special Prices on the Popular Medical Guardian Product 2Health News:Medical Alert Systems Website Now Offering Special Prices on the Popular Medical Guardian Product 3Health News:iFitDress.com Releases a New Range of Cheap Evening Gowns 2Health News:Teen Birth Rate Has Dropped Dramatically in Last Two Decades: CDC 2Health News:Teen Birth Rate Has Dropped Dramatically in Last Two Decades: CDC 3
... ages, even small changes affect incidence, study finds ... affect older adults, risk of diabetes, a new study ... lifestyle and incidence of diabetes over 10 years in ... lifestyle factors examined included physical activity, dietary habits, tobacco ...
... for first time in the Middle East and the Asia-Pacific ... of confirmed cases of swine flu in the United States ... all the new cases coming from a New York City ... infectious disease. , Some news reports Tuesday were listing the ...
... Early and Accurate Carbon Monoxide Exposure Detection Following ... Purchase Rad-57sIRVINE, Calif., April 28 ... of Pulse CO-Oximetry(TM) and Measure-Through Motion and Low-Perfusion ... Pulse CO-Oximeter has been added to the Federal ...
... Challenge Faced by Troops Coming Home from WarCAMBRIDGE, Mass., ... Construction and Veterans Affairs Appropriations Subcommittee on behalf of ... Development Institute (ALS TDI), last Thursday. Dr. Appel ... therapeutic development, such as the one at ALS TDI. ...
... Solutions conducting further research to identify which processes ... While sustained excellence in cardiac care is rare, ... of cardiac care -- acute myocardial infarction (AMI), ... graft surgery (CABG) -- have more cardiac patient ...
... 28 , WHO: Myles Druckman, MD, a leading disease outbreak ... past, Dr. Druckman has been interviewed by, ... The Washington Post, about SARS, avian flu, and other, ... to discuss the swine flu outbreak and associated topics, ...
Cached Medicine News:Health News:Lifestyle Factors Tied to Older Adults' Diabetes Risk 2Health News:Some Reports Put Number of U.S. Swine Flu Cases at 50 2Health News:Some Reports Put Number of U.S. Swine Flu Cases at 50 3Health News:Some Reports Put Number of U.S. Swine Flu Cases at 50 4Health News:Some Reports Put Number of U.S. Swine Flu Cases at 50 5Health News:FEMA Adds Masimo Rad-57(R) Pulse CO-Oximeter(TM) to Required Medical Equipment List 2Health News:FEMA Adds Masimo Rad-57(R) Pulse CO-Oximeter(TM) to Required Medical Equipment List 3Health News:FEMA Adds Masimo Rad-57(R) Pulse CO-Oximeter(TM) to Required Medical Equipment List 4Health News:FEMA Adds Masimo Rad-57(R) Pulse CO-Oximeter(TM) to Required Medical Equipment List 5Health News:ALS Therapy Development Institute Delivers Impassioned Testimony to Congressional Subcommittee on Veterans Affairs 2Health News:ALS Therapy Development Institute Delivers Impassioned Testimony to Congressional Subcommittee on Veterans Affairs 3Health News:Sustaining Excellence in All Aspects of Cardiac Care Rare But Lives Could Be Saved If More Patients Were Treated at Top-Performing Hospitals 2Health News:Sustaining Excellence in All Aspects of Cardiac Care Rare But Lives Could Be Saved If More Patients Were Treated at Top-Performing Hospitals 3Health News:Available for Interviews: Pandemic, Disease Outbreak Expert to Discuss Swine Flu 2Health News:Available for Interviews: Pandemic, Disease Outbreak Expert to Discuss Swine Flu 3
(Date:8/20/2014)...  The National Association of Drug Diversion Investigators ... the real-time, pseudoephedrine (PSE) blocking system in Kentucky. The ... (NPLEx), automatically blocks unlawful PSE sales and helps ... make arrests. Data released by NPLEx shows electronic ... the sale of more than 23,478 boxes of medicine ...
(Date:8/20/2014)... 20, 2014 Reportlinker.com announces ... is available in its catalogue: ... Control (Sterilization, Disinfection, Testing and Treatment) ... Given the cost of ... has increased for solutions that can ...
(Date:8/20/2014)... Aug. 20, 2014 Reportbuyer.com has added a ... Industry https://www.reportbuyer.com/product/98394/Global-Cardiac-Defibrillators-Industry.html This ... US$ Million by the following Product Segments: Implantable/Internal Cardiac ... analytics for the US, Canada , ... , Asia-Pacific , Middle ...
Breaking Medicine Technology:Kentucky's Stop-Sale System Achieves Significant Results In Battle Against Meth 2The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 2The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 3The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 4The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 5The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 6Global Cardiac Defibrillators Industry 2Global Cardiac Defibrillators Industry 3Global Cardiac Defibrillators Industry 4Global Cardiac Defibrillators Industry 5Global Cardiac Defibrillators Industry 6Global Cardiac Defibrillators Industry 7Global Cardiac Defibrillators Industry 8Global Cardiac Defibrillators Industry 9Global Cardiac Defibrillators Industry 10Global Cardiac Defibrillators Industry 11Global Cardiac Defibrillators Industry 12Global Cardiac Defibrillators Industry 13Global Cardiac Defibrillators Industry 14Global Cardiac Defibrillators Industry 15Global Cardiac Defibrillators Industry 16Global Cardiac Defibrillators Industry 17Global Cardiac Defibrillators Industry 18Global Cardiac Defibrillators Industry 19Global Cardiac Defibrillators Industry 20
... Jan. 26 Liquent, ... - a hosted software as a service (SaaS) solution ... regulatory dossiers.  Omnicare Clinical Research is a leading Phase I ... medical device industries. , LiquentConnect enables organizations to ...
... , SAN DIEGO , Jan. 26 ... company, today announced the execution of a commercialization agreement ... distribute, promote and sell PROLEUKIN® (aldesleukin) in the ... for treatment in adults with metastatic melanoma and metastatic ...
Cached Medicine Technology:Omnicare Clinical Research Licenses LiquentConnect to Create Added Value for Clients 2Omnicare Clinical Research Licenses LiquentConnect to Create Added Value for Clients 3Prometheus Acquires Exclusive Rights to PROLEUKIN(R) (aldesleukin) in the U.S. 2Prometheus Acquires Exclusive Rights to PROLEUKIN(R) (aldesleukin) in the U.S. 3Prometheus Acquires Exclusive Rights to PROLEUKIN(R) (aldesleukin) in the U.S. 4
6 mm tying platform. Round knurled handle with polished finish. Teeth: 0.3 mm, 1 x 2. Orientation: Left hand....
0.12 mm, 1 x 2 teeth set at 45 degrees with 6 mm tying platform. Wide serrated handle with polished finish....
Stainless steel model of the popular Nordan titanium Colibri forceps. Tying platform with 0.12 mm teeth for grasping delicate structures. Flattened round handle with polished finish....
0.12 mm, 1 x 2 teeth set at 45 degrees with 4.5 mm tying platform. Serrated handle with polished finish....
Medicine Products: