Navigation Links
Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
Date:5/20/2010

Children with certain variants who were treated with low-dose cancer drug at higher risk, study shows

THURSDAY, May 20 (HealthDay News) -- A new study finds that survivors of childhood cancer with certain genetic variations are more likely than other survivors to develop heart disease.

Researchers say the findings could help them personalize treatment for certain children with cancer to prevent the toxic effects of anthracycline chemotherapy upon the heart.

"Although we depend heavily on anthracyclines for treating children with cancer, we are fully aware of their toxic effects to the heart. We also know that some patients -- despite being exposed to higher doses -- don't develop heart problems, while others with little exposure have considerable cardiac damage," said study senior author Dr. Smita Bhatia, professor and chair of the department of population sciences at the City of Hope National Medical Center in Duarte, Calif., in a news release.

"Our results are a good example of how understanding a cancer patient's genetic makeup can help us better tailor individual therapies," Bhatia said.

About eight out of every 10 children with cancer survive, but they may suffer from health problems related to treatment later in life.

The researchers studied 165 childhood cancer survivors who were diagnosed with heart disease between 1996 and 2008, and compared them to a control group of 323 cancer survivors without heart disease. Among the children who had been treated with low doses of anthracyclines, particular genetic variants of the CBR gene boosted the risk of heart disease.

In the future, oncologists may be able to screen for these gene variants and if necessary, to choose a therapy that will not damage the heart.

The study is scheduled to be released June 7 at the American Society of Clinical Oncology annual meeting in Chicago.

More information

The U.S. National Library of Medicine has more on childhood cancer.



-- Randy Dotinga



SOURCE: American Society of Clinical Oncology, May 20, 2010, press release.


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New research identifies modifiable risk factors for heart disease
2. Magnetic field measurements of the human heart at room temperature
3. Summit Medical Group hosts “Go Red Day” to Raise Awareness of Heart Disease and Stroke
4. Top 10 Ways to Avoid a Heart Attack This Super Bowl
5. Blood Thinner Combos Risky for Heart Attack Patients
6. HeartMath Offers Free Certificates that Celebrate Love and the Heart
7. Texas Health Dallas Launches Screening Program for Female Heart Disease
8. NHLBI funds preclinical tests on devices for infants and children with congenital heart defects
9. Surgery on beating heart thanks to robotic helping hand
10. Renowned Cardiologist Offers Heart Healthy Tips for the Holiday Season
11. American Heart Month Recognized Feb. 1-28, 2010
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... “America On The ... identity. “America On The Brink” is the creation of published author, William Nowers. ... great-grandchildren. As a WWII veteran, he spent thirty years in the Navy. ...
(Date:10/12/2017)... ... October 12, 2017 , ... The ... demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, ... to meet the highest standard. , These products are also: Gluten Free, ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... drug delivery system that we intend to develop to enable prevention of a ... lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... On Saturday, ... a treadmill relay – Miles by Moonlight to raise money for the American Heart ... or more. , Teams will work together to keep their treadmills moving for ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... in wound care advancements to physician colleagues, skilled nursing facility medical directors and ... the Treacherous Waters of Wound Care." , "At many of these conferences we ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... Pa. , Oct. 12, 2017 ... leader in innovative solutions for injectable drug administration, today ... before the market opens on Thursday, October 26, 2017, ... the results and business expectations at 9:00 a.m. Eastern ... (U.S.) or 253-336-8738 (International). The conference ID is 94093362. ...
(Date:10/11/2017)... 11, 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), ... in Las Piedras, Puerto Rico , ... Following a ... sustained minor structural damage, temporary loss of power and ... been completed, manufacturing operations have resumed, and the company ...
(Date:10/5/2017)... Ill. , Oct. 5, 2017  In ... Association of Oral and Maxillofacial Surgeons (AAOMS) released ... opioids – to be used as a first-line ... pain. Recognizing ... the AAOMS White Paper "Opioid Prescribing: Acute and ...
Breaking Medicine Technology: