Navigation Links
Heart, Bone Problems May Follow Prostate Cancer Treatment
Date:4/27/2009

Men on hormone-lowering therapy may require close monitoring, researchers say,,

MONDAY, April 27 (HealthDay News) -- Though proven effective, treating prostate cancer with the testosterone-lowering treatment known as androgen deprivation therapy may raise men's risk for developing bone fractures and fatal cardiovascular disease, a new study suggests.

The likelihood of developing either side effect remains low, the researchers noted. But the study shines fresh light on the question of how best to weigh the potential benefits of androgen deprivation therapy (ADT) against the potentially serious complications that can ensue.

"It is important to point out that these adverse outcomes due to ADT are all preventable, so it's up to a patient's doctor to be vigilant of changes in either cardiovascular or skeletal health that might develop as a result of the therapy," said the study's lead author, Lockwood Taylor, a doctoral candidate in the division of epidemiology and disease control at the University of Texas Health Science Center in Houston.

The findings will appear in the June 1 issue of Cancer.

To assess side effects from ADT, Taylor and his colleagues reviewed 14 studies from 1966 to 2008 that focused on skeletal and cardiovascular side effects linked to ADT among men battling prostate cancer.

They found that ADT boosted the risk for overall fracture by 23 percent relative to men with prostate cancer not undergoing treatment.

Similarly, the chances of dying from heart disease were 17 percent higher among men with cancer on ADT than those not on ADT.

They also pointed to two large studies that had indicated a substantial increase in the risk for developing diabetes among ADT patients.

"It would certainly be important to point out that, although we observed some statistically significant increases in the relative risk for these side effects, the absolute risks are still very low," Taylor stressed.

"But I would say that doctors should certainly monitor their patients on ADT for changes in bone mineral density, and, if they see a decrease, then they should consider some preventive therapies," he advised. "They should also be vigilant for abnormal lipo [blood fat] profiles, in terms of cholesterol levels and serum levels of insulin, which are markers for both cardiovascular and skeletal fracture."

He said that doctors could prescribe statin drugs to help lower cholesterol, while encouraging lifestyle changes to improve diet and physical activity.

Dr. Nelson Neal Stone, a clinical professor of urology and radiation oncology at the Mount Sinai School of Medicine in New York City, said that the findings "reinforce what we already know".

"It's been well known for a while that ADT boosts a patient's risk for fracture, just like it happens among women who go on anti-estrogen therapy for breast cancer," Stone noted. "And there have been several studies published in the last three to five years that find that men who go on the therapy are at an increased risk for all sorts of cardiovascular issues."

"While we all know that this therapy is needed to prevent the progression of metastases, it is true that while you are preventing a serious event on the one hand you are potentially putting the patient at risk," Stone said.

"So the bottom-line is that we have to be careful about who we put on ADT," he said. And research into preventive techniques needs to continue, he said, "because the therapy obviously entails some potentially severe side effects."

More information

The American Cancer Society has more on prostate cancer.



SOURCES: Lockwood Taylor, M.P.H., doctoral candidate, division of epidemiology and disease control, School of Public Health, University of Texas Health Science Center, Houston; Nelson Neal Stone, M.D., clinical professor, urology and radiation oncology, Mount Sinai School of Medicine; New York City; June 1, 2009, Cancer


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Another Study Links Western Diet to Heart, Health Risks
2. Healthy Heart, Healthy Home
3. Single Mutation in Mitochondrial DNA Weakens Heart, Muscles
4. One Drink May Help Heart, But Two Is Too Many
5. Statement of Robert Jarvik, MD, President and CEO of Jarvik Heart, Inc. Regarding the Lipitor DTC Advertisements
6. Survival rates exceed national averages for UCSF heart, liver and lung transplant programs
7. Omega-3 Fatty Acids Protect the Spinal Cord, Heart, Brain and Eyes
8. Pacific Heart, Lung & Blood Institute Position on Ban Asbestos Legislation
9. When It comes to Matters of the Heart, Almonds Are a Multi-Tasker
10. CARDIA Studies Open Window on Heart, Lung Diseases
11. Red Wine Compound Helps Heart, May Slow Aging
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Heart, Bone Problems May Follow Prostate Cancer Treatment
(Date:5/27/2016)... ... May 27, 2016 , ... Each year ... complementary medicine. Allison Outerbridge is this year’s Life University winner of ... at the university’s Student Leadership Awards ceremony. , Outerbridge is approaching her last ...
(Date:5/26/2016)... ... 26, 2016 , ... W.S. Badger Co. Inc ., the maker of ... When Work Works Award for its use of effective workplace strategies to increase business ... project administered by the Families and Work Institute (FWI) and the Society for Human ...
(Date:5/26/2016)... ... May 26, 2016 , ... Connor Sports, ... as a partner for the Tamika Catchings Legacy Tour that will commemorate ... leader in hardwood basketball surfaces in all forms and levels of the game, Connor ...
(Date:5/26/2016)... ... May 26, 2016 , ... There are nearly 14.5 million ... million cancer survivors worldwide. On Sunday, June 5, 2016, communities around the world will ... Survivors Day®. , National Cancer Survivors Day® is an annual worldwide Celebration of ...
(Date:5/26/2016)... ... May 26, 2016 , ... An April Gallup survey found ... The 550 employees of Sun Health Senior Living (SHSL) may not share ... their doctor and prescription copays for the year, while holding the line on increasing ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... LONDON , May 24, 2016 ... erfüllt beide primären Endpunkte ... und Überlegenheit in ‚ausgezeichneter plus guter ... aufsteigenden Colons    ,      (Logo: ... B.V. gab heute neue positive Daten von der ...
(Date:5/24/2016)... Mass. , May 24, 2016  NxStage Medical, ... technology company focused on advancing renal care, today announced ... plans to participate in the following schedule of investor ... be made available at http://ir.nxstage.com/ . ... Jefferies Healthcare Conference NY, NY           Friday, June ...
(Date:5/24/2016)... HONG KONG , May 24, 2016 /PRNewswire/ ... primer stent de doble terapia del mundo, introduce ... fístula arteriovenosa. OrbusNeich, una compañía global ... cambian las vidas, ha expandido su cartera incluyendo ... catéteres balón JADE™ y Scoreflex™ PTA son los ...
Breaking Medicine Technology: