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Hearing-loss-prevention drugs closer to reality thanks to new UF test
Date:1/17/2013

l in two first-of-a-kind clinical trials of therapeutics designed to determine if noise-induced hearing loss can be prevented in humans. The first study uses a dietary supplement called Soundbites, manufactured by Hearing Health Science, a University of Michigan bioscience spinoff company. Soundbites contains the vitamin A precursor beta carotene, vitamins C and E and the mineral magnesium. This antioxidant formula, the patent for which Le Prell shares, has prevented temporary and permanent hearing loss in laboratory animals.

In the other ongoing study, participants take a drug called SPI-1005 produced by Sound Pharmaceuticals Inc. The test capsule contains a new molecule called ebselen that mimics a protective inner ear protein.

The Food and Drug Administration will monitor the studies to ensure openness, analytical rigor and participant safety as the researchers try to get badly needed drugs onto the market.

"We really want to find out what's going to work and we want to make it possible for strategies that do work to get in the hands of the people who need them," Le Prell said.


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Contact: Jill Pease
jpease@phhp.ufl.edu
352-273-5816
University of Florida
Source:Eurekalert  

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