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Hearing-loss-prevention drugs closer to reality thanks to new UF test
Date:1/17/2013

are routinely exposed to noise as they work.

Le Prell's model is the first to use controlled music levels to reliably cause low-level, temporary hearing loss in human participants. Other studies have used beeps or tones, user-selected music levels, or music exposures that don't result in temporary hearing loss. Three monitoring boards ensured that studies of the UF model met national safety standards for research in humans. Co-investigator Patrick Antonelli, M.D., the George T. Singleton Professor and chair of the UF department of otolaryngology, provided onsite supervision of study participant safety, and collaborators at the University of Michigan and Southern Illinois University were involved in study design and safety discussions.

"Dr. Le Prell started with a unique idea to create a reversible noise-induced hearing loss and has established solid groundwork for this new model in the use of clinical drug testing," said hearing expert Jianxin Bao, Ph.D., an associate professor of otolaryngology and biology and biomedical sciences at Washington University School of Medicine in St. Louis, who was not involved in the UF study. "As for every new model, several unknown factors exist for this elegant experiment model, which requires further detailed studies."

To induce temporary hearing loss, study participants listened to rock or pop music on a digital music player via headphones for four hours at sound levels ranging from 93 decibels the noise level of a power lawn mower to 102 decibels, the noise of a jackhammer. Each participant got a hearing test four times, 15 minutes to three-and-a-quarter hours after his or her listening session, as well as follow-up tests one day and one week later. Fifteen minutes after the music stopped, those who listened to the highest music levels had lost just a small amount of hearing six decibels, on average. Hearing returned to normal within three hours.

Le Prell's group will use this testing mode
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Contact: Jill Pease
jpease@phhp.ufl.edu
352-273-5816
University of Florida
Source:Eurekalert  

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Hearing-loss-prevention drugs closer to reality thanks to new UF test
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