Navigation Links
'Healthy' individuals may be at risk for heart disease
Date:9/7/2008

WINSTON-SALEM, N.C. In the face of a growing obesity epidemic in the United States, researchers at Wake Forest University Baptist Medical Center have new study results that indicate that how much fat a person has is not as important as where that fat is located when assessing risk for cardiovascular events and metabolic disease.

"We are facing an obesity epidemic, which obviously affects many things metabolic abnormalities, cardiovascular disease, etc.," said Jingzhong Ding, M.D., lead researcher and an assistant professor of gerontology. "Now we are finding out that where the fat is distributed is of high importance."

The findings of the study, funded by the National Heart, Lung and Blood Institute and the National Institutes of Health, will appear in the September issue of the American Journal of Clinical Nutrition, a publication of the American Society for Nutrition.

For the study, researchers used cardiac and CT scans to measure multiple fat depots in 398 white and black participants from Forsyth County, N.C., ages 47-86. They found that the amount of fat a person had deposited around organs and in between muscles (nonsubcutaneous fat) had a direct correlation to the amount of hard, calcified plaque they had. Calcified plaque itself is not considered risky, but it is associated with the development of atherosclerosis, or the presence of less stable, fatty deposits in the blood vessels that can lead to heart attack and stroke.

"Our hypothesis was that this kind of fat is quite different from subcutaneous fat, or fat just below the skin," Ding said. "Subcutaneous fat may not be as bad as having fat deposited around organs and in between muscles."

Last month, Ding published results of a similar study showing that fat deposited around the heart (pericardial fat) is associated with calcified plaque in the arteries and therefore may be worse than having a high BMI or a thick waist.

"For the previous study, our hypothesis was that pericardial fat released inflammatory cytokines and free fatty acids directly into the coronary arteries, leading to endothelial dysfunction, which initiates atherosclerosis," Ding said.

Ding is continuing long-term studies to investigate whether individuals with excessive fat deposited in and around organs and muscles may be at higher risk of cardiovascular disease and cardiac events regardless of overall body fat.

"We know that even thin people could have excessive non-subcutaneous fat," Ding said. "If this hypothesis is confirmed, we should look for ways to specifically target the non-subcutaneous fat depot."


'/>"/>

Contact: Jessica Guenzel
jguenzel@wfubmc.edu
336-716-3487
Wake Forest University Baptist Medical Center
Source:Eurekalert

Related medicine news :

1. Produce for Kids(R) and PBS KIDS(R) Partner for a Second Year with Nationwide School-Based Healthy Eating Campaign
2. Families Urged to Use Go Red Corazon Family Tree to Begin a Heart-Healthy Legacy
3. During the Recent Chino Based Earthquake Did You Know What to Do? The City of Burbank Senior Services Division and the National Alliance For Healthy Communities Would Like to Help.
4. NARSAD Introduces Healthy Minds Across America, an International Event Recognizing the Toll of Mental Illness, on Sunday, Sept. 14
5. Part of the in-group? A surprising new strategy helps reduce unhealthy behaviors
6. Healthy people and enhancement drugs
7. Message to Birmingham Residents: Forgo Fad Dieting and Join the Campaign for Healthy Weight
8. WXYZ-TV/Channel 7 is On Your Side With Healthy Living For Kids; Free Immunizations for Children on Sunday, August 24 at Charles H. Wright Museum of African American History
9. Jessica Simpson Lends Healthy Image for Drink Smart Campaign
10. Fruits & Veggies - More Matters Helps Moms Instill Healthy Eating Habits
11. Preparing To Send Your Children Off To School? Healthy Breakfast, Lunch and Snack Ideas From Cabot(R) Can Contribute to a Better, More Productive School Year
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... 2016 , ... LaserShip, a regional parcel carrier that services the eastern U.S., ... last Friday in order to aid in the Flint water crisis. In 2014, LaserShip ... located in Clio, only 15 miles away from Flint. , “We have deep roots ...
(Date:2/10/2016)... ... February 10, 2016 , ... As part of its ongoing ... February 2016. Each webinar features a dynamic expert and thoughtful presentation to give ... patients and facilities. Both events are free to attend, but registration is ...
(Date:2/10/2016)... ... 10, 2016 , ... The Wickman Agency in Garland, TX ... local community. Pledging to select a new beneficiary every 60 days, the agency ... goal is to bring community awareness to important local causes by forming campaigns ...
(Date:2/10/2016)... ... ... Dr. Jessica Barron, of Barron Family Dental in Thornton, Colorado , is ... the North Metro Denver area. The new dental practice focuses on comfort where patients ... the most relaxing environment. , While some dental visits can create anxiety for patients, ...
(Date:2/10/2016)... ... ... Gout is like no other joint pain. It strikes suddenly, like flicking on ... redness. It is triggered by the crystallization of uric acid within the joints. It ... to the February 2016 issue of Harvard Men's Health Watch. , The large joint ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... Inc. (Vanda) (NASDAQ: VNDA ), today announced financial ... year ended December 31, 2015. --> ... for Vanda with the continued growth of HETLIOZ in ... for Non-24," said Mihael H. Polymeropoulos, M.D., Vanda,s President ... product portfolio builds on this success and underscores Vanda,s ...
(Date:2/10/2016)... --> --> This press release is intended for U.S. ... Japan .  --> A separate press release has been prepared for ... continues to strengthen its presence in ... continues to strengthen its presence in Japan ... to strengthen its presence in Japan ...
(Date:2/10/2016)... A new report from business intelligence provider GBI Research - Alzheimer,s ... will more than double from just under $5 billion in 2014 to an ... 11%. Canada , France , ... , the UK, and Japan , and will primarily be ... Canada , France , Germany , ...
Breaking Medicine Technology: