Navigation Links
Health benefits of exercise may depend on cellular degradation, UT Southwestern researchers report
Date:1/20/2012

DALLAS Jan. 20, 2012 The health benefits of exercise on blood sugar metabolism may come from the body's ability to devour itself, UT Southwestern Medical Center researchers report in the journal Nature.

Autophagy is a process by which a cell responds to starvation and other stresses by degrading damaged or unneeded parts of itself to produce energy. It is sometimes called the cell's housekeeping pathway.

"Exercise is known to have many health benefits but the mechanisms have been unclear. Autophagy is also known to have several health benefits, and these benefits correspond closely to the effects of exercise. We hypothesized that some of the health benefits of exercise might be explained through autophagy," said senior author Dr. Beth Levine, professor of internal medicine and microbiology who leads the Center for Autophagy Research at UT Southwestern.

Dr. Levine, a Howard Hughes Medical Institute (HHMI) investigator at the medical center, decided to focus on one specific health effect of exercise the ability of exercise to prevent blood sugar abnormalities in the face of a high-fat diet. Her mouse study provides the first evidence that exercise stimulates autophagy.

The researchers found that mice genetically unable to increase autophagy in response to short-term exercise have decreased endurance and fail to experience the normal benefits of exercise on blood sugar metabolism.

This discovery led the team to investigate whether autophagy is important in the protective effects of chronic exercise on diabetes. A high-fat diet induced diabetes-like changes in blood sugar metabolism in both control mice and in test mice that were genetically unable to increase autophagy above baseline levels, said Dr. Congcong He, lead author and a postdoctoral researcher in Dr. Levine's lab. However, the researchers found that exercise reversed these blood sugar abnormalities in control mice but not in the autophagy-deficient mice.

"Our finding that exercise fails to improve glucose metabolism in autophagy-deficient mice strongly suggests that autophagy is an important mechanism by which exercise protects against diabetes," said Dr. Levine. "It also raises the possibility that activation of autophagy may contribute to other health benefits of exercise, including protection against cancer, neurodegenerative diseases and aging.

Dr. Levine has made fundamental discoveries previously that are in large part credited for expanding the field of autophagy research. In 1999, she identified the first mammalian autophagy gene, beclin 1, and its link to the suppression of breast cancer, which marked the first discovery of an association between defects in an autophagy gene and a human disease.

She similarly is credited with demonstrating that autophagy functions in innate immunity protecting against lethal viral encephalitis as well as initially reporting that autophagy plays a role in lifespan extension, shown in a study of C. elegans worms.


'/>"/>

Contact: Deborah Wormser
deborah.wormser@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Related medicine news :

1. Carolinas HealthCare System Volunteers to Join Navy Rescue Mission in Haiti
2. SXC Health Solutions to Host Fiscal 2009 Fourth Quarter and Year End Results Conference Call
3. A New Website Series Improves Appearance and Health City by City
4. Diet-to-Go Welcomes 2 Key Philadelphia Fitness Centers as Partners-in-Health
5. Quantum Health Appoints Stark as Executive Vice President of Sales
6. New Report: The Internet Has More Influence Over Consumer Health Actions than Traditional DTC Channels
7. Satellite Healthcares Sheila Doss Elected Western Chapters Coordinator-Elect of the American Nephrology Nurses Association
8. Changing the Course of Kids Health
9. Mental Health America Encourages Journalists, Media Professionals to Submit Entries for 2010 Media Awards
10. Idaho House Moves State Closer to Health Care Disaster
11. UNT Health Science Centers Roby Helps Identify Bodies of Chiles Patio 29
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Health benefits of exercise may depend on cellular degradation, UT Southwestern researchers report
(Date:6/27/2016)... ... June 27, 2016 , ... ... patient payment industry today announced its strategic partnership with Connance, a healthcare ... , The two companies’ proven, proprietary technology combine to provide health systems, ...
(Date:6/26/2016)... ... 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic ... World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. ... some of the world’s leading providers of cereal and other breakfast foods. Its residents ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... have been diagnosed with endometriosis. These women need a treatment plan to not ... comprehensive approach that can help for preservation of fertility and ultimately achieving a ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, ... Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms ... Final Cut Pro X . Simply select a ProHand generator and drag it above ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary ... Work award to iHire in recognition of their exemplary accomplishments in worksite health promotion. ... Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced ... Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality ... - Global Forecast to 2021" report to their ... global pharmaceutical excipients market is projected to reach USD ... in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... 2016 Roche (SIX: RO, ROG; OTCQX: RHHBY) ... Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated testing ... With this clearance, Roche is the first IVD company ... for sepsis risk assessment and management. PCT ... PCT levels in blood can aid clinicians in assessing ...
(Date:6/23/2016)... June 23, 2016 Capricor ... ), a biotechnology company focused on the discovery, ... that patient enrollment in its ongoing randomized HOPE-Duchenne ... exceeded 50% of its 24-patient target. Capricor expects ... third quarter of 2016, and to report top ...
Breaking Medicine Technology: