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'Headache' Publication Describes Potential Mechanistic Rationale for LEVADEX(TM) Favorable Adverse Event Profile
Date:9/22/2009

not stimulate receptors thought to be responsible for the adverse event profile characteristics of IV DHE.

"We believe that these receptor studies could explain the lower adverse event incidence seen in clinical trials with LEVADEX to date because of the novel pharmacokinetic profile of our formulation and delivery method," said Shashidhar H. Kori, M.D., vice president of clinical development and medical affairs of MAP Pharmaceuticals. "In Phase 2 and Phase 3 clinical trials, LEVADEX has shown the potential to provide rapid and sustained relief of migraine symptoms and good tolerability for patients. Based on our receptor studies and clinical trials to date, we believe that LEVADEX has the potential to provide a treatment alternative for the many patients who suffer from the debilitating effects of migraine."

About LEVADEX(TM)

LEVADEX orally inhaled migraine therapy is a novel migraine therapy in Phase 3 development. Patients administer LEVADEX themselves using the company's proprietary TEMPO inhaler. LEVADEX has been designed to be differentiated from existing migraine treatments. It is a novel formulation of dihydroergotamine (DHE), a drug used intravenously in clinical settings to effectively and safely treat migraines. Based on clinical results, the company believes that LEVADEX has the potential to provide both fast onset of action and sustained pain relief and other migraine symptom relief in an easy-to-use and non-invasive at-home therapy.

LEVADEX is designed to incorporate the multiple beneficial mechanisms of action that allow DHE to block initiation of migraine, limit pain, reduce inflammation and stop a migraine at any point in the migraine cycle. Based on research to date, including the FREEDOM-301 trial, the company believes the unique pharmacokinetic profile of LEVADEX has the potential to effectively treat migraines, while minimizing the side effects commonly seen with DHE an
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SOURCE MAP Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
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