Navigation Links
'Headache' Publication Describes Potential Mechanistic Rationale for LEVADEX(TM) Favorable Adverse Event Profile
Date:9/22/2009

MOUNTAIN VIEW, Calif., Sept. 22 /PRNewswire-FirstCall/ -- MAP Pharmaceuticals, Inc. (Nasdaq: MAPP) today announced publication of results from an in vitro study of its novel LEVADEX(TM) (MAP0004) orally inhaled migraine therapy in development exploring the potential mechanism by which the pharmacokinetics (PK) and pharmacodynamics of LEVADEX may produce fewer adverse events than those seen with intravenous dihydroergotamine (DHE). Results will be published in a manuscript titled Reduced Adverse Event Profile of Orally Inhaled DHE (MAP0004) vs IV DHE: Potential Mechanism in an upcoming issue of Headache: The Journal of Head and Face Pain and are available currently in the online version.

LEVADEX, a novel formulation of DHE that is administered via oral inhalation using the company's proprietary TEMPO(R) inhaler, recently met all four primary endpoints in the efficacy portion of a Phase 3 clinical trial. As presented in a late-breaking session at the 14th Congress of the International Headache Society, in the trial LEVADEX provided therapeutic levels of DHE but with lower rates of adverse events, such as dizziness, nausea and paresthesia, than those historically seen with intravenous dosing of DHE.

The in vitro study measured receptor binding and functional activity of DHE at the maximum plasma concentrations (Cmax) achieved in human PK trials after IV administration or after LEVADEX inhalation. The IV DHE Cmax was at least ten times higher than LEVADEX Cmax while the AUCs were approximately the same. The lower LEVADEX Cmax was associated with markedly different receptor binding and functional activity. LEVADEX provided Cmax levels sufficiently high to trigger anti-migraine receptors to the same degree as IV dosing, but did
'/>"/>

SOURCE MAP Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related medicine news :

1. SAGE to publish leading international headache journal Cephalalgia
2. High-Octane Caffeine May Trigger Headaches
3. Children with headache
4. Surgery for Neck Pain May Also Relieve Headaches
5. Jefferson Headache Center study shows novel, orally inhaled migraine therapy effective
6. Neck surgery for cervical spine disorders found to alleviate associated headaches
7. Neck Surgery for Cervical Spine Disorders Found to Alleviate Associated Headaches
8. Many Kids Outgrow Chronic Headaches
9. Viles & Beckman, LLC: Stop Your Headache NOT Your Liver
10. EHE International Supports the National Headache Foundation
11. New Online Tool Helps People With Headache Take Control, Get Relief
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... May 23, 2013 Medical device development ... the Sheikh Zayed Institute for Pediatric Surgical Innovation at ... Annual Pediatric Surgical Innovation Symposium will be held June ... It will address critical issues in pediatric surgical ... are available on the Sheikh Zayed Institute website. ...
(Date:5/23/2013)... (PRWEB) May 23, 2013 Dr. ... their condition specific remedies are now available at Whole ... Niguel, CA 92677. The line of natural biotherapy formulas ... Market Chain. , Represented by Brandstorm HBC (Los Angeles, ... Foods Markets throughout California, Nevada and Arizona, as well ...
(Date:5/23/2013)... After working continuously for weeks and ... Shopping Cart Elite officially announced the launch ... Arizona based online store retailing in wheels, seats, parts, ... new stores to our clientele has always been our ... Soshkin. “We are extremely elated with this addition as ...
(Date:5/23/2013)... 23, 2013 FindUrgentCare.com launched updates to ... search option for patients. The new advanced feature ... including payment preferences, offered services, insurances accepted and hours ... way to narrow their search and receive targeted results ... provide ambulatory care to walk-in patients in a non-emergency, ...
(Date:5/23/2013)... (PRWEB) May 23, 2013 Greenville ... that all team members and doctors have recently ... professional rescuer with an Automated External Defibrillator (AED). ... (AED) is a medical device designed to analyze ... to victims of ventricular fibrillation to restore the ...
Breaking Medicine News(10 mins):Health News:Children’s National to Host Symposium on Medical Device Development 2Health News:Dr. Garber's Natural Solutions Now Available at Whole Foods Market, Laguna Niguel, CA 2Health News:Shopping Cart Software Provider, Shopping Cart Elite Officially Announces the Launch Of Redsandmotorsports.com 2Health News:Find Urgent Care Launches New Site Design and Functionality to Provide Advanced Search Options for Users in Need of an Urgent Care Clinic 2Health News:Find Urgent Care Launches New Site Design and Functionality to Provide Advanced Search Options for Users in Need of an Urgent Care Clinic 3Health News:Greenville Oral & Maxillofacial Surgeons Announce CPR Re-Certification 2
... Common Shares Issued and Listed on OTCBB, ... (OTC Bullets and Board: CHHB) (,China,Bio-Immunity" or "the ... share exchange agreement with Lawford Asia Limited (,Lawford,).,According ... all of the issued and outstanding stock of ...
... Grant Stevens, MERRIMACK, N.H., Aug. 6 ... Medical Inc. announced today that Grant,Stevens, MD, will ... to offer,the SmoothShapes(R) system for longer lasting cellulite ... dynamic light therapy, in addition,to contoured rollers and ...
... eDiets.com,Inc. (Nasdaq: DIET ), leveraging the power of ... to everyone, today announced,results for the second quarter and ... the second quarter of 2008 were $6.5 million, compared ... for the quarter was $(3.1),million, or $(0.12) per diluted ...
... Raritan, NJ, August 6, 2008 The nation,s first, ... (cSSTIs), known as SSTIR (the Skin and Soft Tissue ... plans to enroll more than 1,200 hospitalized patients by ... better understand treatment patterns and provide data to help ...
... study finds , , WEDNESDAY, Aug. 6 (HealthDay News) -- Stroke ... times as likely to die in the hospital or be ... new Canadian study suggests. , The finding is based ... recovery from an ischemic stroke. Ischemic strokes are the most ...
... than to adults. That,s one reason why abstinence-only ... sexual activity, according to new University of Washington research., , ... treated abstinence and sexual activity as opposites. However, teenagers ... Tatiana Masters, lead author of a new study and ...
Cached Medicine News:Health News:China Bio-Immunity Corporation Completes Share Exchange and Reverse Merger 2Health News:China Bio-Immunity Corporation Completes Share Exchange and Reverse Merger 3Health News:China Bio-Immunity Corporation Completes Share Exchange and Reverse Merger 4Health News:New Anti-Cellulite Treatment Prepares Women for Fall's Short Skirts 2Health News:New Anti-Cellulite Treatment Prepares Women for Fall's Short Skirts 3Health News:eDiets.com(R) Announces Q2 2008 Results 2Health News:eDiets.com(R) Announces Q2 2008 Results 3Health News:eDiets.com(R) Announces Q2 2008 Results 4Health News:eDiets.com(R) Announces Q2 2008 Results 5Health News:eDiets.com(R) Announces Q2 2008 Results 6Health News:eDiets.com(R) Announces Q2 2008 Results 7Health News:Ortho-McNeil initiates first-of-its-kind skin infection registry 2Health News:GI Bleeding After Stroke Raises Death Risk 2Health News:GI Bleeding After Stroke Raises Death Risk 3Health News:When it comes to abstinence teens, adults aren't speaking the same language 2Health News:When it comes to abstinence teens, adults aren't speaking the same language 3
(Date:5/23/2013)... NEW YORK , May 23, 2013  Echo ... has committed to waive down the Acceptance Threshold from ... Affected plus one Elan Share in accordance with the ... to the conditions summarized below. Under the ... to acquire Elan (NYSE: ELN ) for ...
(Date:5/23/2013)... 23, 2013 Nederland keurt als ... urinewegsymptomen geassocieerd met BPH Astellas Pharma ... Astellas Pharma Inc, gebaseerd in Tokyo ... aan dat het Nederlandse College ter Beoordeling van Geneesmiddelen ... De handelsvergunning verleend voor VESOMNI is voor ...
(Date:5/22/2013)... , May 22, 2013 Advanced Prenatal Therapeutics ... device that will help alleviate the high blood pressure ... cartridge is expected to be the first medical device ... maternal and fetal death. Every year, preeclampsia ... United States . It is characterized by high ...
Breaking Medicine Technology:Royalty Pharma Reduces Acceptance Condition to 50% Plus One Share 2Royalty Pharma Reduces Acceptance Condition to 50% Plus One Share 3Royalty Pharma Reduces Acceptance Condition to 50% Plus One Share 4Royalty Pharma Reduces Acceptance Condition to 50% Plus One Share 5Royalty Pharma Reduces Acceptance Condition to 50% Plus One Share 6Royalty Pharma Reduces Acceptance Condition to 50% Plus One Share 7Royalty Pharma Reduces Acceptance Condition to 50% Plus One Share 8Royalty Pharma Reduces Acceptance Condition to 50% Plus One Share 9Royalty Pharma Reduces Acceptance Condition to 50% Plus One Share 10Astellas ontvangt handelsvergunning voor VESOMNITM van Nederlandse College ter Beoordeling van Geneesmiddelen 2Astellas ontvangt handelsvergunning voor VESOMNITM van Nederlandse College ter Beoordeling van Geneesmiddelen 3Astellas ontvangt handelsvergunning voor VESOMNITM van Nederlandse College ter Beoordeling van Geneesmiddelen 4Advanced Prenatal Therapeutics - Using Targeted Apheresis to Treat Preeclampsia 2
... , Elsevier,s Pageburst platform to be ... Program Elsevier, the leading global provider of ... today that West Kentucky Community and Technical College ... Technical College System and a public, two-year, degree-granting institution ...
... patent covering tumor suppression technologies, including the company,s lead ... The University of Texas System by the ... discovery that chromosome 3p21.3 genes act as cancer suppressors. ... as FUS1, the anti-cancer agent in Oncoprex ...
Cached Medicine Technology:West Kentucky Community and Technical College Embraces Elsevier's Digital Textbook Platform for Radiography Program 2West Kentucky Community and Technical College Embraces Elsevier's Digital Textbook Platform for Radiography Program 3Genprex Announces New Patent Issuance in Japan 2
Bartels Clostridium difficile Toxin A Enzyme Immunoassay (EIA) is intended for the qualitative detection of Clostridium difficile Toxin A in human faecal specimens as an aid in the diagnosis of Clost...
One step Immuno-Chromatographic Assay for the detection of C. difficile toxin A....
... CCD cameras provide fast, accurate, reliable and ... quality at an excellent price. , , ... TOMEY TR-4000 Auto Refractor provides highly accurate ... is obtained simply by pushing a button. ...
... Rechargeable, cordless slit-lamp microscope Portable, for ... Easy selection of slit width , ... halogen lamp light source , Simultaneous ... pack , Supports digital / video ...
Medicine Products: