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Having Older Grandfather May Raise Child's Autism Risk: Study
Date:3/20/2013

families with older grandparents, it must be remembered that autism was still extremely infrequent even in families with the oldest grandparents," said Dr. Andrew Adesman, chief of developmental and behavioral pediatrics at Steven & Alexandra Cohen Children's Medical Center of New York, in New Hyde Park. "Thus, older parents and grandparents should not be unduly worried."

The new research was published on the same day that the U.S. Centers for Disease Control and Prevention announced that one in every 50 U.S. school children now has an autism spectrum disorder -- up from the 2007 estimate of 1 in 88. The CDC says improved detection and diagnosis are probably responsible for most of that increase.

In the new study, researchers looked at data from Sweden's national registries and compared about 6,000 people with autism to about 31,000 people without the condition. They looked at the age of each person's maternal and paternal grandfather at the time of the individual's birth.

The link between autism and a grandfather's age was significant, the team said, and pointed to the genetic underpinnings of the condition. They noted that previous studies have found a link between older fathers and rising odds for autism in their children, such that men who have a child when age 50 or older have a double the risk of having a child with the disorder.

Mutations lying within sperm cells might be the culprit, the researchers said. Sperm cells undergo division throughout the lifespan, and with each new division errors in the genome can occur. Some of these mutations might remain "silent" in a man's child but then accumulate or re-emerge to cause problems in future generations.

"These findings add further support to the belief that subtle genetic abnormalities -- defects that were previously undetectable -- are likely responsible for some cases of autism," Adesman said.

This type of research might lead to tests that could pinpoint a child's odd
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