Navigation Links
Has osteoporosis treatment failed when a fracture occurs?
Date:8/31/2012

The International Osteoporosis Foundation (IOF) has published practical guidelines to assist clinicians in assessing treatment efficacy in patients who experience a fracture while on medication for osteoporosis.

Osteoporosis drug therapy typically reduces the risk of fracture in the range of 30-70% for vertebral fractures, 40-50% for hip fractures and 15-20% for non-vertebral fractures. Nevertheless, even an effective therapy does not completely eliminate the risk of fracture, and some patients will experience a fracture while complying with their prescribed treatment.

This situation is not just worrying for the patient, it also poses a challenge for the physician who must decide whether to continue or discontinue with the treatment regimen. Does the fracture signify that the patient has failed to respond to the particular treatment? Should the type of treatment be changed? Or is the patient one of a significant minority who fails to respond to available treatments, for a number of many possible reasons?

The IOF Inadequate Responders Working Group, comprised of international experts on IOF's Committee of Scientific Advisors, outlines many of the issues associated with clinical decisions in the treatment of osteoporosis. Professor Adolfo Diez-Perez, chair of the Working Group, explains, "Treatment issues are extremely complex. In addition there is a scarcity of data about the effectiveness of alternative treatments when one has been deemed to have failed. Notwithstanding these complexities and limitations, the Working Group has used the best available evidence to create a check list of pragmatic criteria which can help doctors define treatment failure and take appropriate action."

The position paper, published in the journal 'Osteoporosis International', outlines how the response to treatment in patients who have been complying with their treatment for at least six months can be assessed on the basis of the number of fractures, changes in bone mineral density and bone turnover markers.

Professor Cyrus Cooper, chair of the IOF Committee of Scientific Advisers, stated: "Recent advances in the management of osteoporosis have led to large numbers of patients being treated with a variety of drugs. An increasingly frequent clinical conundrum is the management of a patient who sustains a fracture while on treatment. Although patient and physician may view this as a sign of treatment failure, this is not always the case. The objective of the current practical guidance was to provide a clinical pathway whereby physicians can ascertain whether a patient has failed to respond adequately to an anti-osteoporosis treatment. As a result, doctors will be able to define treatment failure more effectively, and take appropriate action. The algorithm produced pays testimony to the expert input from a host of international scientific advisers, coming together to address this important clinical topic in a timely and efficient manner."


'/>"/>

Contact: L. Misteli
info@iofbonehealth.org
41-229-940-100
International Osteoporosis Foundation
Source:Eurekalert

Related medicine news :

1. Teen Girls Need Bone Health Advice to Stave Off Osteoporosis
2. Major IOF osteoporosis meeting to take place in Kuala Lumpur, Malaysia
3. Meeting in Jordan to educate medical professionals on latest advances in osteoporosis
4. ASBMR task force urges use of fracture liaision services to reduce costly osteoporosis bone breaks
5. US Drug Watchdog Now Offers to Help All Woman Who Used Fosamax For Osteoporosis and Then Had an Unexplained a Femur Break Get to the Best Attorneys
6. US Drug Watchdog Now Offers To Help Women Who Used TheOsteoporosis Drug Called Fosamax And Then Had A Unexplainable Femur Fracture Get To The Best Attorneys Or Law Firms
7. Experts recommend men at risk for osteoporosis undergo bone density testing
8. Certain Genetic Regions May Be Tied to Osteoporosis
9. ESC analysis reveals arrhythmia treatment gaps between Eastern and Western Europe
10. 30-day mortality after AMI drops with improved treatment
11. Personalized antiplatelet treatment improves outcome after PCI
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... December 07, 2016 , ... The Honolulu cosmetic and medical ... which launched October 17, 2016, features comprehensive information regarding a wide range of ... and patients can discover the latest clinical dermatology treatments for medical skin concerns ...
(Date:12/7/2016)... ... 07, 2016 , ... 1105 Media’s Live From program has ... Awards competition. Live From won in the Use of Social Media category. The ... projects undertaken by the media industry’s most innovative marketing professionals. , ...
(Date:12/7/2016)... (PRWEB) , ... December 07, ... ... Technologies, announced its newest portable bioelectronic medicine device WellnessPro Plus for consumers ... Plus substantially enhances the WellnessPro platform by expanding the treatment modalities available ...
(Date:12/7/2016)... ... 07, 2016 , ... “Walking With God: Inspirational Lessons from My Life's Journey”: ... to be aware of God's direction in their lives. “Walking With God: Inspirational Lessons ... and active church leader. , Sanford says, “I enjoy sharing the true ...
(Date:12/7/2016)... ... 07, 2016 , ... Dr. Greg Leyer, the Chief Scientific ... Washington DC workshop on November 2nd. The conference was an opportunity for both ... supplement regulations. , Dr. Leyer spoke about two main topics at the ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... Dec. 6, 2016 The pen needles market ... from USD 1.65 billion in 2016, growing at a ... to 2021. Over the years, the pen needles ... cater to the growing demand for safety injections in ... development of safety pen needles with an aim to ...
(Date:12/6/2016)... , Dec. 6, 2016  Nearly 30 million people ... from the epidemic of diabetes. 1 However, nearly ... elevated glucose levels (hyperglycemia) and significant glucose variability. 2 ... complications, including cardiovascular events. If left untreated, hyperglycemia can ... eye disease or blindness. 3 As ...
(Date:12/6/2016)... , Dec. 6, 2016 With opioids commonly used ... in the prescription drug market that has led to nationwide fatalities. ... seven to eight times stronger than heroin or morphine, resulting in ... ... Smolkin , vice president, clinical operations, Behavioral Health for HMC HealthWorks, ...
Breaking Medicine Technology: