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Harvard expert on inflammation's role in obesity receives Columbia's 2010 Naomi Berrie Award
Date:11/19/2010

promoted the concept of the existence of "metabolic inflammasomes" that integrate metabolic processes with immune response and insulin signaling. These concepts link organelle function to metabolic homeostasis and suggest critical mechanisms involved in metabolic functions of endoplasmic reticulum and its failure in obesity.

Dr. Hotamisligil is the 2010 recipient of the Turkish Government Ministry's Health & Medical Excellence Award. In 2009, he was elected a Fellow of American Association for the Advancement of Science (AAAS). He obtained his Ph.D. in biological chemistry and molecular pharmacology from Harvard Medical School in 1995 and his M.D. from Ankara University Medical School in Ankara, Turkey in 1986. He is currently an advisory member of the Juvenile Diabetes Research Foundation (JDRF) Research Portfolio.

Naomi Berrie Fellow in Diabetes Research Awardee Focuses on Metabolic Pathways of Diabetes

The award to a the junior investigator goes to Rebecca A. Haeusler, Ph.D., a post-doctoral research scientist in the lab of Domenico Accili, M.D., director of the Columbia University Diabetes and Endocrinology Research Center at the Naomi Berrie Diabetes Center. Dr. Haeusler was cited for her work in understanding the roles of a certain transcription factor, FOXO1, in the disordered lipid metabolism and cardiovascular disease in diabetes.

Through her work she has found that FOXO1 protects against excessive hepatic lipid production in the context of hyperglycemia, and that its inhibition a consequence of intensive insulin treatment used in diabetes may paradoxically exacerbate some of the lipid abnormalities of diabetes. These insights have immediate implications for the clinical management of diabetes.

Dr. Haeusler hopes to extend these insights into the common abnormalities of lipid metabolism that are observed in patients with type 2 diabetes. "Understanding those processes will help us understand how atherosclerosi
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Contact: Alex Lyda
alyda@columbia.edu
212-305-0820
Columbia University Medical Center
Source:Eurekalert

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