Navigation Links
Harnessing miRNA natural gene repressors for anticancer therapy
Date:12/1/2008

Michel Sadelain and colleagues, at Memorial Sloan-Kettering Cancer Center, New York, have developed a new approach to modulate the expression of genes for therapeutic purposes, and used this to mediate effective anticancer therapy in mice.

Small, noncoding RNA molecules known as miRNAs are powerful natural repressors of gene expression. In the study, the miRNA miR-181a was harnessed to segregate expression of genes in immune cells known as T cells at different stages of their development. miR-181a is highly expressed in developing T cells, in which it represses expression of many genes, and markedly downregulated in mature T cells. Sadelain and colleagues engineered mouse bone marrow cells to express therapeutic genes only when miR-181a expression is downregulated. These cells were then transplanted into mice and allowed to develop into mature T cells. Expression of the genes (and therefore the proteins made from the genes) was not detected in developing T cells, i.e., when miR-181a was highly expressed, but was detected in mature T cells, i.e., when miR-181a was downregulated. When the genes controlled by miR-181a were responsible for making proteins that target T cells to tumor cells expressing the protein hCD19, the mice that were transplanted with the engineered bone marrow cells were able to reject tumors expressing hCD19. The authors therefore suggest that it might be possible to harness miRNA-regulated therapeutic gene expression in stem cellbased therapies, including cancer immunotherapy.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Harnessing Human Energy for Medical Good
2. Harnessing the Mind to Manage Irritable Bowel Syndrome
3. Sigma-Aldrich Announces mirPremier(TM) microRNA Isolation Kit for miRNA Purification
4. Scientists discover new role for miRNA in leukemia
5. Scientists Develop Natural Protection for Stored Foods
6. Preparation for Natural Disasters Critical for People With Diabetes, Chronic Medical Conditions
7. SIV infection of natural hosts provides new insights into HIV disease complexity
8. Big Relief for Tiny Itch Mites Found in All Natural Spray Remedy
9. Natural aorta grafts have few side effects for infection-prone patients
10. Fitness Champion Natalie Waples to be Spokesperson for Natural Nutrition International Direct Marketing Campaign
11. New Herbal Water Creating Taste Sensation: Ayalas Herbal Water Has No Calories, No Preservatives and No Artificial Additives. Just All the Natural Benefits of Herbs!
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... ... July 24, 2017 , ... Cheerag D. Upadhyaya , M.D., ... Bloch Neuroscience Institute (SLMBNI), part of Saint Luke’s Health System . Dr. ... Cheerag D. Upadhyaya, MD. M.Sc., FAANS joins Stanley P. Fisher, M.D., who ...
(Date:7/24/2017)... Angeles, California (PRWEB) , ... July 24, 2017 ... ... building fire in Oakland, California effectively destroyed the construction site and threatened numerous ... a July 7th article on NBCLosAngeles.com. Los Angeles Area consulting ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... initiatives designed to promote awareness for Topricin’s revolutionary, natural, after-burn skin care product, ... of the leading causes of long term skin conditions, including cancer. In ...
(Date:7/24/2017)... ... July 24, 2017 , ... The 2017 NCSL International Workshop ... theme focuses on the new ISO/IEC 17025 standards. This marks the first time ... and calibration will be changed. , As an exhibitor, METTLER TOLEDO will ...
(Date:7/24/2017)... Napa, Calif. (PRWEB) , ... July 24, 2017 ... ... massager, on Tuesday received the prestigious StorErotica “Consumer’s Choice” Award, for favorite sex ... presented at the 11th annual StorErotica Awards to be consumer voted. The Magic ...
Breaking Medicine News(10 mins):
(Date:7/17/2017)... 2017  MedX Holdings, Inc., the manufacturer and global ... rehabilitation equipment, today announced the national roll out of ... the gold standard for the treatment of low back ... equipment. How it ... or practice who prescribe the MedX Home Back Machine ...
(Date:7/13/2017)... Products, a leader in medical product innovation and global patient care, ... hospice patient care. ... Centurion Medical Products ... management and emotional comfort are part of a hospice,s primary mission. ... unneeded emergency department admission due to severe fecal impaction. One of ...
(Date:7/12/2017)... , July 12, 2017  Eli Lilly and Company ... agreement with generic companies to resolve pending patent litigation in ... Virginia regarding the Cialis ® (tadalafil) ... on April 26, 2020. As part of the agreement, Cialis ... September 27, 2018. "The unit dose patent for ...
Breaking Medicine Technology: