Navigation Links
Harnessing miRNA natural gene repressors for anticancer therapy
Date:12/1/2008

Michel Sadelain and colleagues, at Memorial Sloan-Kettering Cancer Center, New York, have developed a new approach to modulate the expression of genes for therapeutic purposes, and used this to mediate effective anticancer therapy in mice.

Small, noncoding RNA molecules known as miRNAs are powerful natural repressors of gene expression. In the study, the miRNA miR-181a was harnessed to segregate expression of genes in immune cells known as T cells at different stages of their development. miR-181a is highly expressed in developing T cells, in which it represses expression of many genes, and markedly downregulated in mature T cells. Sadelain and colleagues engineered mouse bone marrow cells to express therapeutic genes only when miR-181a expression is downregulated. These cells were then transplanted into mice and allowed to develop into mature T cells. Expression of the genes (and therefore the proteins made from the genes) was not detected in developing T cells, i.e., when miR-181a was highly expressed, but was detected in mature T cells, i.e., when miR-181a was downregulated. When the genes controlled by miR-181a were responsible for making proteins that target T cells to tumor cells expressing the protein hCD19, the mice that were transplanted with the engineered bone marrow cells were able to reject tumors expressing hCD19. The authors therefore suggest that it might be possible to harness miRNA-regulated therapeutic gene expression in stem cellbased therapies, including cancer immunotherapy.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Harnessing Human Energy for Medical Good
2. Harnessing the Mind to Manage Irritable Bowel Syndrome
3. Sigma-Aldrich Announces mirPremier(TM) microRNA Isolation Kit for miRNA Purification
4. Scientists discover new role for miRNA in leukemia
5. Scientists Develop Natural Protection for Stored Foods
6. Preparation for Natural Disasters Critical for People With Diabetes, Chronic Medical Conditions
7. SIV infection of natural hosts provides new insights into HIV disease complexity
8. Big Relief for Tiny Itch Mites Found in All Natural Spray Remedy
9. Natural aorta grafts have few side effects for infection-prone patients
10. Fitness Champion Natalie Waples to be Spokesperson for Natural Nutrition International Direct Marketing Campaign
11. New Herbal Water Creating Taste Sensation: Ayalas Herbal Water Has No Calories, No Preservatives and No Artificial Additives. Just All the Natural Benefits of Herbs!
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2017)... ... September 19, 2017 , ... Spain’s popular line of health ... coming soon to RonnieColemanNutrition.com. , ACPG Laboratories has been in business for ... brand reliant on the healing properties of plants, a proven science known as ...
(Date:9/19/2017)... ... , ... For decades doctors, nurses, and other healthcare providers have been trained ... and calculating their cardiovascular disease (CVD) risk in the next 10 years. , ... today: an estimated 10-year risk prediction! , Imagine if the weatherman says there is ...
(Date:9/19/2017)... Reno, Nev. (PRWEB) , ... September 19, 2017 ... ... 20 students across the country with the Davidson Fellows Scholarship on September 27 ... awards for projects in Science, Technology, Engineering, Mathematics, Literature and Music. , “I ...
(Date:9/19/2017)... ... September 19, 2017 , ... Emergency nursing expertise, ... Certified Emergency Nurse (CEN®) certification according to a large-scale study announced today ... study, conducted by the Human Resources Research Organization (HumRRO) in late 2016 and ...
(Date:9/18/2017)... ... September 19, 2017 , ... Food Proteins ... , expected to grow at the fastest CAGR of 9.1% over the next ... Protein Trends & Growth Opportunities in Asia’ – highlighting alternative proteins, sustainable food ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... Caris Life Sciences, a leading innovator ... of precision medicine, today announced results from two ... molecular profiling approach in guiding therapeutic strategies in ... (CGP+) with Caris Molecular Intelligence ® to ... level, leading to more therapeutic options and improved ...
(Date:9/7/2017)... WARSAW, Ind. , Sept. 7, 2017  Zimmer ... leader in musculoskeletal healthcare, today announced that it will ... Annual Global Healthcare Conference at the Grand Hyatt hotel ... September 11, 2017 at 11:40 a.m. Eastern Time. ... accessed via Zimmer Biomet,s Investor Relations website at ...
(Date:9/6/2017)... , Sept. 6, 2017  Robert G. Szewc, ... Pinnacle Professional Member in recognition of his contributions to ... serves as a Nephrologist at the practice of Kidney ... medicine, kidney care and hypertension solutions. He has worked ... years of career experience, as well as expertise in ...
Breaking Medicine Technology: