Navigation Links
Harmless soil-dwelling bacteria successfully kill cancer
Date:9/4/2011

A bacterial strain that specifically targets tumours could soon be used as a vehicle to deliver drugs in frontline cancer therapy. The strain is expected to be tested in cancer patients in 2013 says a scientist at the Society for General Microbiology's Autumn Conference at the University of York.

The therapy uses Clostridium sporogenes a bacterium that is widespread in the soil. Spores of the bacterium are injected into patients and only grow in solid tumours, where a specific bacterial enzyme is produced. An anti-cancer drug is injected separately into the patient in an inactive 'pro-drug' form. When the pro-drug reaches the site of the tumour, the bacterial enzyme activates the drug, allowing it to destroy only the cells in its vicinity the tumour cells.

Researchers at the University of Nottingham and the University of Maastricht have now overcome the hurdles that have so far prevented this therapy from entering clinical trials. They have introduced a gene for a much-improved version of the enzyme into the C. sporogenes DNA. The improved enzyme can now be produced in far greater quantities in the tumour than previous versions, and is more efficient at converting the pro-drug into its active form.

A fundamental requirement for any new cancer therapy is the ability to target cancer cells while excluding healthy cells. Professor Nigel Minton, who is leading the research, explains how this therapy naturally fulfils this need. "Clostridia are an ancient group of bacteria that evolved on the planet before it had an oxygen-rich atmosphere and so they thrive in low oxygen conditions. When Clostridia spores are injected into a cancer patient, they will only grow in oxygen-depleted environments, i.e. the centre of solid tumours. This is a totally natural phenomenon, which requires no fundamental alterations and is exquisitely specific. We can exploit this specificity to kill tumour cells but leave healthy tissue unscathed," he said.

The research may ultimately lead to a simple and safe procedure for curing a wide range of solid tumours. "This therapy will kill all types of tumour cell. The treatment is superior to a surgical procedure, especially for patients at high risk or with difficult tumour locations," explained Professor Minton. "We anticipate that the strain we have developed will be used in a clinical trial in 2013 led by Jan Theys and Philippe Lambin at the University of Maastricht in The Netherlands. A successful outcome could lead to its adoption as a frontline therapy for treating solid tumours. If the approach is successfully combined with more traditional approaches this could increase our chance of winning the battle against cancerous tumours."


'/>"/>

Contact: Laura Udakis
l.udakis@sgm.ac.uk
44-118-988-1843
Society for General Microbiology
Source:Eurekalert  

Related medicine news :

1. Not All Birthmarks Harmless, Expert Says
2. Sex between adolescents in romantic relationships is often harmless to their academics
3. Harmless Brain Abnormalities in Kids Pose Disclosure Dilemmas
4. Color, Odor Changes in Urine Usually -- But Not Always -- Harmless, Reports Harvard Women's Health Watch
5. Babies Born With Heart Disease Often Harmed by Gut Bacteria
6. Dangerous Bacteria Hide Out in Nurses, Doctors Uniforms
7. UF medicinal chemists modify sea bacteria byproduct for use as potential cancer drug
8. Bacterial Strain Behind Black Death Plague Is Likely Extinct: Study
9. Study: Afghan patients a common source of drug-resistant bacteria
10. New Bacteria Linked to Tattoo Infections
11. Are Kids Brown-Bagging Bacteria?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Harmless soil-dwelling bacteria successfully kill cancer
(Date:7/22/2017)... , ... July 21, 2017 , ... Reassured For Life ... brokerage firm servicing Albertans,” says owner and licensed broker Nerissa McNaughton. “I launched this ... be difficult, but it is a very necessary conversation. I make it easy. As ...
(Date:7/22/2017)... (PRWEB) , ... July 22, 2017 , ... ... patients with irreparable rotator cuff repairs the opportunity to return to sports and ... American Orthopaedic Society for Sports Medicine’s Annual Meeting in Toronto, Ontario, ...
(Date:7/21/2017)... ... July 21, 2017 , ... The Bryant ... to families and business owners in the Dalton region, is working in conjunction ... overcoming sexual assault and physical abuse. , The GreenHouse is headquartered in Dalton ...
(Date:7/21/2017)... ... July 21, 2017 , ... The Ellis Agency, an eastern Georgie provider ... in a community wide charity event with the goal of bringing in support for ... woman who lives with epilepsy, recently launched a charity campaign of her own by ...
(Date:7/21/2017)... (PRWEB) , ... July 21, 2017 , ... ... insurance assistance and financial planning services to communities in the greater Birmingham area, ... to provide resources to underprivileged young people in the region. , The Chris ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... , July 21, 2017  Endo International plc ... completing a comprehensive review of its manufacturing network, the ... and distribution facilities in Huntsville, Alabama ... take place over the next 12 to 18 months. ... impacted by declining volumes of commoditized products and these ...
(Date:7/19/2017)... , July 19, 2017  Mako Medical Laboratories ... and the Military Family Assistance Fund (MFA) to bring ... to visit with their families one last time ... to coordinate the travel and logistics needed for these ... deployed soldiers and their families. We just wish we ...
(Date:7/14/2017)... plc (NASDAQ: ENDP ) will announce its second-quarter 2017 ... management team will host a conference call and webcast before the ... The dial-in number to access the call is U.S./ Canada ... 45397076. Please dial in 10 minutes prior to the scheduled start ... the call will be available from August 8, 2017 at 11:30 ...
Breaking Medicine Technology: