Navigation Links
Harmless soil-dwelling bacteria successfully kill cancer
Date:9/4/2011

A bacterial strain that specifically targets tumours could soon be used as a vehicle to deliver drugs in frontline cancer therapy. The strain is expected to be tested in cancer patients in 2013 says a scientist at the Society for General Microbiology's Autumn Conference at the University of York.

The therapy uses Clostridium sporogenes a bacterium that is widespread in the soil. Spores of the bacterium are injected into patients and only grow in solid tumours, where a specific bacterial enzyme is produced. An anti-cancer drug is injected separately into the patient in an inactive 'pro-drug' form. When the pro-drug reaches the site of the tumour, the bacterial enzyme activates the drug, allowing it to destroy only the cells in its vicinity the tumour cells.

Researchers at the University of Nottingham and the University of Maastricht have now overcome the hurdles that have so far prevented this therapy from entering clinical trials. They have introduced a gene for a much-improved version of the enzyme into the C. sporogenes DNA. The improved enzyme can now be produced in far greater quantities in the tumour than previous versions, and is more efficient at converting the pro-drug into its active form.

A fundamental requirement for any new cancer therapy is the ability to target cancer cells while excluding healthy cells. Professor Nigel Minton, who is leading the research, explains how this therapy naturally fulfils this need. "Clostridia are an ancient group of bacteria that evolved on the planet before it had an oxygen-rich atmosphere and so they thrive in low oxygen conditions. When Clostridia spores are injected into a cancer patient, they will only grow in oxygen-depleted environments, i.e. the centre of solid tumours. This is a totally natural phenomenon, which requires no fundamental alterations and is exquisitely specific. We can exploit this specificity to kill tumour cells but leave healthy tissue unscathed," he s
'/>"/>

Contact: Laura Udakis
l.udakis@sgm.ac.uk
44-118-988-1843
Society for General Microbiology
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Not All Birthmarks Harmless, Expert Says
2. Sex between adolescents in romantic relationships is often harmless to their academics
3. Harmless Brain Abnormalities in Kids Pose Disclosure Dilemmas
4. Color, Odor Changes in Urine Usually -- But Not Always -- Harmless, Reports Harvard Women's Health Watch
5. Babies Born With Heart Disease Often Harmed by Gut Bacteria
6. Dangerous Bacteria Hide Out in Nurses, Doctors Uniforms
7. UF medicinal chemists modify sea bacteria byproduct for use as potential cancer drug
8. Bacterial Strain Behind Black Death Plague Is Likely Extinct: Study
9. Study: Afghan patients a common source of drug-resistant bacteria
10. New Bacteria Linked to Tattoo Infections
11. Are Kids Brown-Bagging Bacteria?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Harmless soil-dwelling bacteria successfully kill cancer
(Date:7/3/2015)... ... 03, 2015 , ... First Choice Emergency Room , the largest network ... as the new Medical Director of its Frisco facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:7/3/2015)... ... July 03, 2015 , ... Yisrayl Hawkins, Pastor and ... this week that he says will reveal biblical truth and expose popular lies regarding ... Your Bible Say Don’t Have Sex”, immediately goes into the core of the subject ...
(Date:7/3/2015)... ... 2015 , ... The Celebrity Dresses is currently running a promotion through July ... will have the opportunity to get 10% discount on orders that are over $100. ... have to use coupon codes or remember redemption codes. , There is a ...
(Date:7/2/2015)... ... July 02, 2015 , ... sweetFrog Enterprises, LLC. is pleased to announce the opening of its ... the Lone Star State. The premium frozen yogurt chain was listed as #22 on the ... 19 in the Village at Bachman Lake, is located at:, 3701 W. Northwest Highway, STE ...
(Date:7/2/2015)... ... ... Following the recent report by JAMA Internal Medicine published on ... Samir Becic emphatically declared a war on obesity in the United States. , "Obesity ... must understand the magnitude of this discovery. For that reason, I am declaring, along ...
Breaking Medicine News(10 mins):Health News:First Choice Emergency Room Announces Dr. Mariah N. Manzanares as Medical Director of Frisco, TX Facility 2Health News:First Choice Emergency Room Announces Dr. Mariah N. Manzanares as Medical Director of Frisco, TX Facility 3Health News:Yisrayl Hawkins Explains What the Bible Really Says about Sex in New Publication This Week 2Health News:Celebrity Fashion Summer Party Dresses on sale at TheCelebrityDresses.com 2Health News:sweetFrog Opens 18th Location in the Lone Star State 2Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 2Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 3Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 4
... by a jackal in Bihar's Gopalganj district, but there are ... patients. ,In the last two days, ... and children - in half a dozen villages under the ... ,The injured are being treated at different hospitals ...
... bio-technology pharma company from Zurich, Switzerland has developed a ... months at a time . ,The drug ... blood pressure by contracting vessels, by inducing antibodies. ... CYT006-AngQb developed by Cytos Biotechnology reduced systolic blood pressure ...
... in that US doctors tend to prescribe unwanted, even possibly ... the name of lecture assignments. ,Lawmakers are ... to disclose payments made to doctors and also keep within ... earn more money from drug makers than doctors in any ...
... heiress Paris Hilton under house arrest, has defended his ... from a 'life-threatening' psychiatric condition called decompensating. ... mental state to the point of severe depression, nervousness ... Simple Life star's condition was even more complicated because ...
... Louis University has found that a patient's emotional state plays ... surgery. ,After hip surgery, two tests are ... is a clinical measure of hip function given by the ... considers a wide variety of factors in determining the overall ...
... at the University of York and Hull York Medical School ... folate. ,Folate is a vitamin that comes ... and peas. Fortified cereal products, sunflower seeds as well as ... been claiming that adding folate to bread or flour will ...
Cached Medicine News:Health News:US Lawmakers Considering Legislation to Restrict Payments by Drug Companies to Doctors 2Health News:US Lawmakers Considering Legislation to Restrict Payments by Drug Companies to Doctors 3Health News:Emotions Play 'significant Role' in Recovery from Hip Surgery 2
(Date:7/2/2015)... , July 2, 2015 ... as ,Friendly Aedes aegypti , , reduced ... Brazil by 95%, well below ...      (Logo: http://photos.prnewswire.com/prnh/20150630/227348LOGO) , The journal PLOS ... trial of Oxitec,s genetically engineered mosquitoes. The results showed ...
(Date:7/2/2015)... Research and Markets( http://www.researchandmarkets.com/research/nlfg34/cancer ) has announced the ... by Application - Forecast to 2020" report to their offering. ... $13.1 Billion in 2020 from an estimated $7.1 Billion in 2015, ... dominated by North America , followed by ... of the World (RoW). The cancer diagnostics market in ...
(Date:7/2/2015)... Pharma Major Lupin Limited today announced the acquisition of ... subject to certain closing conditions. The acquisition marks ... 765 billion in sales, placing it as one of the ... Health). For over a decade, Russian pharmaceutical market recorded double ... Russia to be one of the ...
Breaking Medicine Technology:Oxitec Mosquito Works to Control Aedes aegypti in Dengue Hotspot 2Oxitec Mosquito Works to Control Aedes aegypti in Dengue Hotspot 3Global Cancer Diagnostics Market Report 2015 - Technology, Imaging and by Applications Forecasts to 2020 for the $13 Billion Industry 2Lupin Acquires Biocom in Russia 2Lupin Acquires Biocom in Russia 3
... 1, 2011 Hologic, Inc. (NASDAQ: HOLX ) ... Financial Officer, will be presenting at the Nasdaq OMX 27th ... 11:15am (GMT). Interested parties are invited to listen ... the investor section of Hologic,s website at www.hologic.com/investors-overview . ...
... Md., Dec. 1, 2011 The Food and Drug Administration ... products, including a potentially contaminated nasal spray ... unapproved drug sold as a testosterone booster ... alerts were prompted by reports FDA received from health care ...
Cached Medicine Technology:
... Get the equivalent of 7.5 liters out ... will you need two machines for your high-flow ... OXYMIZER Disposable Oxygen-Conserving Devices function like standard conservers, ... flow of oxygen required to saturate a patient. ...
Lightweight Pneumatic Conserver., ,NOTE: All models passed the ASTM PS 127-00 regulator ignition safety test....
Lightweight Pneumatic Conserver., ,NOTE: All models passed the ASTM PS 127-00 regulator ignition safety test....
... an average 5:1 increase in usage time at ... a standard cannula. , ,The combination of ... oxygen patients a superior alternative to liquid oxygen. ... , ,NOTE: Each ...
Medicine Products: