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Hard to Treat Diseases, Inc. (HTDS) Experiments with Hyperbaric Oxygenation (HBO) Traumatic Brain Injury
Date:8/3/2009

BELGRADE, Serbia, Aug. 3 /PRNewswire-FirstCall/ - Hard to Treat Diseases, Inc. (HTDS:PK), http://www.htdsmedical.com announced that researchers in its Slavica BioChem division have reported results on experiments in which the potential beneficial effects of Hyperbaric oxygenation (HBO) after traumatic brain injury have been explored. These experiments were conducted in collaboration with doctors from the Hyperbaric Medical Center, School of Medicine, University of Belgrade, Serbia.

Hyperbaric oxygen (HBO) has been used as a primary or adjunctive therapy over the last 50 years with controversial results, both in experimental and clinical studies. However, the mechanisms underlying the neuroprotective vs. neurodegenerative effects of HBO treatment are still uncertain.

The results of the research group revealed that repetitive HBO treatments, which started 1 hour after traumatic brain injury significantly, reduced axonal loss and neuronal degeneration, suggesting that HBO was able to attenuate the effects of brain damage by reducing the progression of neuronal injury.

These data indicate that HBO-induced prevention of neurodegeneration might be beneficial in improvement of neurological outcome after traumatic brain injury.

Dr. Sanja Pekovic, Chief Project Scientist, Chief Strategy Officer said (sic) "The experiments were performed on rats, but since we haven't hyperbaric chambers, HBO treatments were performed at the Hyperbaric Medical Center. These data for the first time showed (all was visualized using immunohistochemical technique and specific antibodies to neuronal markers) that HBO prevent axonal loss and neuronal degeneration, since data concerning brain injury are lacking and are controversial. "

Our Washington Poster will be posted on Pink Sheets Supplemental Info Filing as a pdf.

The results were presented by Professor Mirjana Stojiljkovic. (Professor
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SOURCE Hard to Treat Diseases
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