Navigation Links
'Happy hour' gene discovery suggests cancer drugs might treat alcoholism
Date:5/21/2009

l rather incomplete.

Human studies have pointed to a strong genetic component to alcoholism, but identifying the specific genes responsible has proved difficult. Studies have also indicated that an individual's sensitivity to alcohol intoxication acts as a predictor of future alcoholism, with a link between lower initial response and increased risk of addiction. Therefore, Heberlein's team explained, genes and pathways involved in the acute response to alcohol can yield insight into the genetic factors contributing to the more complex process of addiction.

Earlier studies have shown that fruit flies are a useful tool for unraveling the basis for the effects of alcohol. Several genes previously identified as playing a role in fruit flies' alcohol response hold similar roles in mammals.

In search of more in the new study, the researchers screened mutant flies for those less sensitive to ethanol. That screen led them to happyhour, a gene closely related to mammalian enzymes known as the Ste20-family kinases of the GCK-1 subfamily.

Heberlein said they still don't know exactly how alcohol exerts its influence on the EGFR pathway or how that leads to the telltale changes in behavior that come with alcohol intoxication. Those questions will be the subject of future investigation. Her team is also exploring other new gene candidates that turned up in the fly screens. She says that several of those appear to be tied to the EGFR pathway in different ways.

"It's not yet clear how it all fits together," she said. "But the fact that we've come, in an unbiased way, to molecules in the same pathway is telling us this is really, really important."


'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Despite grumbling, most Americans say they are happy at work
2. Most patients who have male-to-female sex-change surgery are happy, despite complications
3. A Happy Halloween Means Safety First
4. A Happy New You in the New Year
5. Be Healthy Be Happy(TM) with the Motherhood(R) Maternity and March of Dimes(R) Bracelet
6. Is your dating partner happy?
7. Smoking doesnt make you happy
8. Happy Marriage, Happy Heart
9. Give and Be Happy
10. Massage Chairs Promote Comfort and Happy Dads for Fathers Day
11. For Women, a Happy Marriage Means Sweet Dreams
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2014)... Pittsburgh, PA (PRWEB) August 23, 2014 ... penis sometimes comes into contact with the dirty water ... or the seat itself," said one of two inventors ... exposure to germs, we developed this protective device." , ... contacting unsanitary toilet surfaces, including the water, bowl and ...
(Date:8/23/2014)... 2014 On Monday, August 18th, ... breach suffered by Community Health Systems, which operates ... 4.5 million records containing Personally Identifiable Information (PII) like ... Mandiant, who was engaged to investigate the incident, the ... group of cyber attackers based in China, who they ...
(Date:8/23/2014)... 2014 Pixel Film Studios, a leader of ... release of ProIntro Vol.3, a customizable title tool for ... tile just by dragging ProIntro Vol.3 in their timeline" says ... a definite time saver and i think our users will ... beautifully designed titles made with Final Cut Pro X users ...
(Date:8/23/2014)... (PRWEB) August 23, 2014 Teen drug ... Carolina. It’s no different in Wilmington, NC. Substance abuse ... are falling victim to drug and alcohol dependency in ... are looking to overcome substance abuse, but don’t know ... adolescent treatment facility can be a challenge because most ...
(Date:8/22/2014)... The IT manager of Top10BestSEOHosting.com is a web professional ... has recently announced that GoDaddy ( http://www.top10bestseohosting.com/go/GoDaddy.com/ ) is ... GoDaddy is a popular supplier of cheap web hosting, ... at affordable rates. It offers three Linux shared hosting ... on the length of the contract. The longest contract ...
Breaking Medicine News(10 mins):Health News:This Time Prominent Hospital Group Falls Prey to Hackers Believed to be Based in China 2Health News:This Time Prominent Hospital Group Falls Prey to Hackers Believed to be Based in China 3Health News:This Time Prominent Hospital Group Falls Prey to Hackers Believed to be Based in China 4Health News:A new plugin was announced today, ProIntro Vol.3 from Pixel Film Studios for Final Cut Pro X 2Health News:Troubled Teens Wilmington Helpline Guides Adolescents to the Path of Recovery 2
... 20, 2009 Researchers at Ben-Gurion University of the Negev ... and terrorist attacks in adolescents, demonstrating that strong social support ... The study, believed to be the first of its ... , the journal of The American Academy of Pediatrics. ...
... , , , WASHINGTON, July 20 The ... , Pro-life leaders to hold press conference discussing potential backlash -- ... to kill the innocent. , , Address: National Press ... Time and Date: 2:00 PM, Tuesday, July 21 , , ...
... looks at costs and benefits of revising treatment guidelines ... therapy soon after an HIV diagnosis should be standard ... cost is a barrier, new research contends. , An ... avoided over a five-year period, the researchers say, if ...
... , CHAPEL HILL, N.C., July 20 RealMed ... partnership to provide RealMed EDI Revenue Management Services to clients ... RealMed will provide services including online ECS claims filing, editing ... Eligibility Verification). In return, TSI Healthcare has committed ...
... , WESTBURY, N.Y., July 20 ... Long Island (OCLI) practice will perform FREE surgery at the Island ... have lost some or all of their vision because of cataracts. ... this outpatient surgical procedure to residents of Nassau, Suffolk and Queens ...
... , , ... , MADISON, N.J., July 20 ... (NYSE: DGX ), today announced that NYCLIX is ... organizations across New York City using the company,s Centergy(TM) ...
Cached Medicine News:Health News:Social support buffers adolescent depression after terrorist attacks: Ben-Gurion University 2Health News:Earlier HIV Treatment Could Save Lives Worldwide 2Health News:RealMed Corporation and TSI Healthcare Announce Strategic Partnership 2Health News:Ophthalmic Consultants of Long Island (OCLI), the Largest and One of the Most Prestigious Multi-Specialty Ophthalmology Practices on Long Island, Participates in Mission Cataract USA 2Health News:Ophthalmic Consultants of Long Island (OCLI), the Largest and One of the Most Prestigious Multi-Specialty Ophthalmology Practices on Long Island, Participates in Mission Cataract USA 3Health News:Quest Diagnostics MedPlus Subsidiary Enables New York Clinical Information Exchange (NYCLIX) to Share Meaningful Data and Enhance Patient Care 2Health News:Quest Diagnostics MedPlus Subsidiary Enables New York Clinical Information Exchange (NYCLIX) to Share Meaningful Data and Enhance Patient Care 3Health News:Quest Diagnostics MedPlus Subsidiary Enables New York Clinical Information Exchange (NYCLIX) to Share Meaningful Data and Enhance Patient Care 4
(Date:8/21/2014)... , Aug. 21, 2014 The spinal column ... the human body. Signals carried to and from the brain ... skills and nervous system. Injury or ailment here can be ... with a loss of control over their body. Though back ... a person,s life, there are more options available to make ...
(Date:8/21/2014)... Aug. 21, 2014 /CNW/ - Eisai Limited is pleased to ... the first-of-its-kind comic book available in Canada ... designed specifically to educate children and their parents about epilepsy, ... affecting more than 300,000 Canadians. Eisai is guided by ... , in which the patient is central – there was ...
(Date:8/21/2014)... Mass. , Aug. 21, 2014  Decision ... COPD,  physicians in Brazil ... follow clinical guidelines and commonly prescribe long-acting beta-agonist ... although they do so within current severe cost/coverage ... (FDCs) that are expected to launch in these ...
Breaking Medicine Technology:Don't Live in Pain: Four Life Improving Benefits of Back Surgery 2Eisai Pleased to Support Canadian Epilepsy Alliance Comic Book that Teaches Children About Epilepsy 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 3
... Food and Drug Administration (FDA) approves many generic drugs that treat a wide variety of ... , (Logo: http://www.newscom.com/cgi-bin/prnh/20090824/FDALOGO ) ... This FDA Consumer Update describes seven significant approvals made by ... , , ...
... to gain acceptance.  Additional financing will allow the Talheim ( Germany ) based company to accelerate the development of new products. , ... , , ... ... ...
Cached Medicine Technology:FDA Consumer Health Information - Generic Drug Roundup: April 2010 2Novalung Records 50% Growth 2Novalung Records 50% Growth 3
CK-MB Control...
For the quantitative in vitro determination of CK-MB in serum and plasma...
For the quantitative in vitro determination of Cholesterol in serum and plasma....
For the quantitative in vitro determination of Alkaline Phosphatase in serum or plasma....
Medicine Products: