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Handheld device for detecting counterfeit and substandard medicines tested by PQM
Date:2/20/2013

Rockville, Md., February 13, 2013 With substandard and counterfeit medicines a dangerous and growing problem in the developing world and elsewhere, identifying new technologies to detect such drugs is an urgent matter. In a new study published in the Journal of Pharmaceutical and Biomedical Analysis, scientists from the U.S. Pharmacopeial Convention (USP) evaluated a handheld Raman device's potential to detect counterfeit and substandard medicines. The device, called TruScan, is currently used to test Active Pharmaceutical Ingredients (API) and finished pharmaceutical products, and it was evaluated for its ability to differentiate among drug products with different APIs, different brands of the same API, and drug products having the same API but of different strengths, with focus on the specificity and precision of the testing. While TruScan could be used successfully in the initial screening for authentication of the identity of certain targeted medicines, it may not be reliable enough to establish whether the medicines are substandard or not. The print version of the study appears in the journal's February issue.

"Thin Layer Chromatography (TLC) test methods, such as Minilab, which PQM uses on a regular basis to detect counterfeit and substandard medicines, have been in the market for several years. They are quite reliable, but require specific training and the use of chemicals," said Mustapha Hajjou, Ph.D., lead author of the study, and a program manager for USP's Promoting the Quality of Medicines program (PQM), which is funded by USAID. "There is an increased interest in other, 'non-invasive' spectroscopic methods to detect counterfeit medicines, including near-infrared (NIR) and Raman spectroscopy, like the device we tested, and those would undoubtedly be simpler to use. We just have to make sure they produce reliable results for various types of medicines including substandard medicines, and that is what we tried to evaluate with the Tr
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Contact: Claudia Costabile
cac@usp.org
301-816-8314
US Pharmacopeia
Source:Eurekalert

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