Navigation Links
Hand bone mineral density is an effective predictor of mortality in rheumatoid arthritis
Date:6/12/2008

Paris, France, Thursday 12 June 2008: Low bone mineral density in the hand is a valid predictor of overall mortality in patients with rheumatoid arthritis (RA) and indicates long-term prognosis, according to a new study presented today at EULAR 2008, the Annual Congress of the European League Against Rheumatism in Paris, France. Digital X-ray radiogrammetry (DXR) demonstrated bone mineral density to be as effective predicting mortality as well-established means of assessment such as radiographic damage and functional disability.

During the study, different standard measures of disease activity were investigated in order to assess their capacity to predict all-cause mortality. Over a period of 27 years (1978 2005), age-sex adjusted proportional hazards models for 84 RA patients, found the following to be significant predictors of mortality:

  • Bone mineral density in the hand (RR=0.55/1SD, 95% CI 0.35-0.87)

  • Steinbrocker functional classification (RR=1.86/1SD, 95% CI 1.35-2.56)

  • The physician's global assessment (RR=1.37/1SD, 95% CI 1.02-1.82)

  • Erythrocyte sedimentation rate (RR=1.86/1SD, 95% CI 1.41-2.46)

Conversely, during this study, certain measures of rheumatic disease activity, including rheumatoid factor, Larsen index, Ritchie index and the patient's global assessment, were not found to be significant predictors of mortality in RA.

The study's lead researcher, Dr Christina Book of Malm University Hospital, Sweden, said: "This long-term study establishes that measurement of bone mineral density in the hand may be an important physical gauge in anticipating the course of rheumatoid arthritis. It offers physicians an effective tool for assessing a patient's disease and so developing the most appropriate individual management plan."

In the study, 152 consecutive patients (119 women, 33 men) with a mean disease duration of 13 years were enrolled. X-rays of the hands at inclusion were available in 108 patients, and in 84 of these, bone mineral density was evaluated by DXR on the same digitised hand X-rays used for scoring radiographic joint damage. Placement of joint prostheses or severe malalignment prevented DXR evaluation in the other 24 patients. Manual measurements, such as dividing the combined cortical thickness by the width of metacarpal II (CCTr) were performed in all 108 patients with X-rays at inclusion. Measures of disease activity and damage at inclusion in the 84 subjects were used to predict mortality by Cox regression models. Furthermore, standardised mortality ratios were computed using the general Swedish population as a benchmark, to assess the overall increased mortality in the group, which was three-folded increased.


'/>"/>

Contact: Rory Berrie / Camilla Dormer
eularpressoffice@uk.cohnwolfe.com
44-077-892-70392
European League Against Rheumatism
Source:Eurekalert

Related medicine news :

1. New Renuva Daily Balance Spray Is Designed to Be the Easiest and Best Way to Take Daily Vitamins and Minerals
2. Bone mineral content continues to increase in obese adolescents during weight loss
3. Study finds widespread vitamin and mineral use among cancer survivors
4. Collagen Matrix, Inc. Receives FDA 510(k) Clearance for SynOss(TM) Synthetic Mineral Bone Graft Material
5. Physicists at CCNY determine density limit for randomly packed spherical materials
6. First study to examine vitamin D insufficiency in pediatric patients with low bone density
7. Neighborhood ethnic density associated with risk of psychosis among immigrants in the Netherlands
8. Bone Density Tests Do Predict Womens Fracture Risk
9. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
10. Whole Milk Cheaper, Effective Contrast Agent for GI Scans
11. Tracking Cancer Drugs Effectiveness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from ... at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center ... care topics including advance care planning, healthcare costs and patient and family engagement. ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... ... the United States, named Dr. Sesan Ogunleye, as the Medical Director of its new ... the facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... ... ... crisis. Her son James, eight, was out of control. Prone to extreme mood shifts and ... him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife on ... say he was going to kill them. If we were driving on the freeway, ...
(Date:6/24/2016)... ... 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited to ... Recovery® program to drive cancer patients to and from their cancer treatments. Comfort ... quality of life and ongoing independence. Getting to and from medical treatments is ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... today announced the appointment of Dr. Edward ... as a Non-Executive Director, effective June 23, 2016.Dr. ... Compensation and Nominations and Governance Committees.  As a ... will provide independent expertise and strategic counsel to ...
Breaking Medicine Technology: