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Halving the radiation dose in cardiac perfusion imaging is now 'feasible'
Date:5/17/2011

present study was designed to test whether radiation dose could be reduced without loss of resolution in the diagnostic images.

Radiation effective dose is measured in millisieverts, and, with conventional protocols, each investigation exposes the patient to a radiation dose of between 8 and 25 mSv. This study compared outcome from two protocols, a conventional full dose injection of tracer substance and a half-dose injection. Each group comprised 109 patients, who were investigated with stress-only, rest-and-stress and stress-and rest imaging. The full dose protocol was applied with dosages ranging between 12 and 32 milicurries (mCi) (depending on patient weight); in the half dose protocol dosages ranged between 5 and 17 mSCi. These were converted to radiation effective dose (in mSv).

Professor Zafrir explains that the study only became possible because of the introduction of new image processing software, which was originally designed to reduce the time it takes to acquire a full diagnostic image. " The aim of our study," she says, "was to use the same software but to assess the feasibility of reducing the tracer dose instead of reducing the acquisition time."

Results showed that 94% of the images from the half-dose protocol were assessed as "excellent to good", suggesting no loss of image quality or diagnostic accuracy when the radiation dose of the perfusion was halved.

Professor Zafrir also reports that 35% of the patients in the half-dose group had only a single stress-only investigation, and they were exposed to a mean of just 1.9 mSv. The total effective dose for stress-rest investigation was 7.19 mSv in the half dose protocol compared to 14.4 mSv in the conventional dose protocol.

"So it's our view that myocardial perfusion imaging is feasible with significant radiation dose reduction," says Professor Zafrir. "We found that image quality using the new processing software was similar to that in conventional prot
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Contact: Jacqueline Partarrieu
press@escardio.org
33-492-947-756
European Society of Cardiology
Source:Eurekalert

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