Navigation Links
Halting bone-building osteoporosis drug use cuts risk for additional atypical femur fracture in half
Date:2/8/2012

SAN FRANCISCO There is growing evidence that supports an association between atypical fractures of the femur a rare break of the thigh bone, typically without trauma and the use of bisphosphonates, drugs proven to enhance bone density and reduce fracture incidence caused by osteoporosis. While the risk for suffering an atypical femur fracture while taking bisphosphonates is still very small just 1 in 1,000 patients after six years of treatment research presented today at the 2012 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS) found that discontinuing bisphosphonate use following an atypical femur fracture can significantly lower the risk for a subsequent atypical fracture.

Scientists believe that bisphosphonates may suppress the body's natural process of remodeling -- where old bone tissue is replaced with new, healthy tissue in some patients, resulting in brittle bones susceptible to atypical fractures, especially in the femur.

Investigators reviewed femur fracture data from Jan. 1, 2007 until Dec. 31, 2009 in patients older than 45 enrolled in a large California HMO. There were 126 patients with an atypical femur fracture who reportedly took bisphosphonates prior to their bone break.

The incidence of a subsequent atypical femur fracture occurring in the other thigh was 53.9 percent in patients who continued bisphosphonates for three or more years after their first fracture, compared to 19.3 percent in patients who discontinued bisphosphonate use. Overall, subsequent atypical femur fractures were decreased by 65.6 percent when bisphosphonates were stopped within one year following the first fracture.

"The risk of a contralateral atypical femur fracture (on the opposite side) increases over time if the bisphosphonates are continued," said lead investigator Richard Dell, MD, a researcher in the Department of Orthopaedics at Kaiser Permanente. "Based on these observations, we recommend discontinuing
'/>"/>

Contact: Kristina Goel
goel@aaos.org
847-384-4034
American Academy of Orthopaedic Surgeons
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Molecular playbook for halting heart failure risk factor uncovered
2. Bone-Building Pills Appear to Lower Invasive Breast Cancer Risk
3. Quantity vs. quality: Long-term use of bone-building osteoporosis drugs
4. Early Ovary Removal May Raise Arthritis, Osteoporosis Risk
5. 1st Middle East and Africa Osteoporosis Meeting opens in Dubai
6. Three steps to unbreakable bones on World Osteoporosis Day
7. Capacity to diagnose osteoporosis doubles in Armenia
8. An important breakthrough at the IRCM associated with osteoporosis
9. Bone experts to present strategies for osteoporosis prevention and care in Dubai
10. Osteoporosis Phase III data at 2011 ASBMR Show oral calcitonin tablet is safe and effective
11. FDA Advisers Call for Revised Labels for Osteoporosis Drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... 2014 Good Neighbor Community Services ... upcoming episode of Innovations with Ed Begley Jr, ... and show times TBA. , In this segment, ... Services’ vision to redefine the traditional approach to ... services. Through passion, innovation, determination, excellence, and collaboration, ...
(Date:7/30/2014)... By Alan Mozes ... -- Parents who want to help their preschooler shed excess ... research suggests. Youngsters whose parents joined them in a ... who were enrolled in a traditional child-only program (an average ... partners also benefited, losing almost 15 pounds over two years, ...
(Date:7/30/2014)... 30, 2014 Volunteers from the Church ... drug abuse this summer with massive distribution of ... can find these volunteers on Strøget, the famous Copenhagen ... for its shopping and its ambiance, some quarter of ... typical summer day. , These activities are part ...
(Date:7/30/2014)... well as evolutionary changes in a living organismhad been ... the genome. , However, recent studies have shown that ... that arise simultaneously and in close proximity to each ... in regions where chromosomal rearrangements take place. , The ... may one day lead to new cancer therapies, according ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 ... authentication, access management and secure communications solutions for ... OneSign ® is the most widely selected single ... Paragon or Horizon electronic medical records (EMR) systems ... of about 11 percent in the last 12 ...
Breaking Medicine News(10 mins):Health News:Good Neighbor Community Services to be Featured in an Upcoming Episode of Innovations With Ed Begley, Jr. 2Health News:Make Kids' Weight Loss a Family Affair, Study Suggests 2Health News:Make Kids' Weight Loss a Family Affair, Study Suggests 3Health News:Make Kids' Weight Loss a Family Affair, Study Suggests 4Health News:Biologists describe mechanism promoting multiple DNA mutations 2Health News:Imprivata Achieves 51 Percent Single Sign-on Market Share Amongst U.S. Hospitals Using McKesson Paragon or Horizon EMR Systems, According to HIMSS Analytics 2
... Researchers at the University of Texas, have shown that use ... cancer.Up to 70 per cent of US women born since ... suggested that use of the hormones in the Pill could ... have failed to reveal a connection. The early Pill users ...
... to day problem among the adolescents. Every day, more than ... young smokers will eventually die from tobacco-related causes.// A new ... are among the driving forces causing young girls to become ... Institute, followed more than 1,500 young girls, beginning at ages ...
... of taking care your medication. Sometimes half a pill does the ... a medication, or be given a double dose of a medicine ... into two or more doses. ,Doctors at the Mayo ... splitting. First, you need to check if your pill is amenable ...
... darkness might prevent retinal damage in diabetes. One of the ... diabetic retinopathy. This results from damage to the retina //- ... which responds to light.In diabetes, the blood supply to the ... rods (the cells responsible for night vision) which have a ...
... a type of ultrasound test may be able to identify ... most common causes of sudden death in young people.The condition, ... different mutations in as many as 10 genes. In HCM, ... pump blood and putting patients at risk of heart failure ...
... at home reduces hospitalisation in those with lung disease. Researchers ... of oxygen on 200 patients with smoker's lungs - where ... in an outpatient clinic, then continued at home. ... proved to be beneficial. The patients had a 40 per ...
Cached Medicine News:Health News:What makes young girls smoke 2Health News:Ultrasound test may detect heart condition early 2
(Date:7/30/2014)... ALEXANDRIA, Va. , July 30, 2014 /PRNewswire-USNewswire/ ... of Managed Care Pharmacy (AMCP) last evening expressed ... developed by the Joint Commission of Pharmacy Practitioners ... other member organizations over a two-year period to ... process for pharmacists.  "Pharmacists are ...
(Date:7/30/2014)... 30, 2014  El Camino Hospital, a leader in ... utilizing the Leaf Patient Monitoring system to help prevent ... of patients susceptible to bed sores. The ... study of the system, which showed dramatic improvement in ... regularly is the one of the most effect ways ...
(Date:7/30/2014)... 30, 2014   Unique Pizza and Subs ... Pink: UPZS), a Delaware Corporation, is pleased to ... Larasan Pharmaceutical Corporation ("Larasan"), a nature-based pharmaceutical company that ... agreement, US-based Larasan will work with Unique to ... through Larasan,s vast distribution network throughout ...
Breaking Medicine Technology:AMCP Endorses JCPP "Pharmacists' Patient Care Process" 2El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 2El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 3Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 2Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 3
... 15, 2011 Patient Safety Technologies, Inc. (the "Company", ... its third quarter of 2011 ended September 30th, 2011. ... the third quarter of 2011, the number of institutions ... the Company lost no customers.  This compares to approximately ...
... (NYSE: BSX ) commends the leadership of Senator ... Kerry (D-MA) for their introduction today of the Patient Access ... The legislation is a thoughtful and well-timed effort to ...  It seeks to improve the ability of companies like Boston ...
Cached Medicine Technology:Patient Safety Technologies Reports Third Quarter 2011 Results 2Patient Safety Technologies Reports Third Quarter 2011 Results 3Patient Safety Technologies Reports Third Quarter 2011 Results 4Patient Safety Technologies Reports Third Quarter 2011 Results 5Patient Safety Technologies Reports Third Quarter 2011 Results 6Patient Safety Technologies Reports Third Quarter 2011 Results 7
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: