Navigation Links
Hallmark Alzheimer's disease changes found in retinas of humans and imaged in live animals
Date:6/24/2010

ufficient detail about these changes, the most definitive diagnosis of Alzheimer's disease comes after an autopsy.

The research team considered the retina a better target for noninvasive imaging of Alzheimer's disease because it is readily accessible and, unlike other components of the eye, it is part of the central nervous system, having a direct connection and thus many similarities with the brain. Previous studies have documented non-specific visual disturbances, eye disorders and certain types of retinal abnormalities occurring with Alzheimer's disease and other neurodegenerative conditions, but this is the first to identify human retinal plaque deposits that could provide a specific diagnostic marker of Alzheimer's disease.

Among the new findings:

  1. In lab tests, plaques in the retinas of mice genetically modified to model Alzheimer's disease could be detected at a very early, pre-symptomatic stage before the plaque appeared in the brain.
  2. A high-resolution, noninvasive optical imaging approach was developed to monitor individual beta-amyloid plaques in the retinas of live mice. The system is based on a harmless specific marker and the adaptation of an existing optical system used to examine rodent eyes.
  3. The research team used a fluorescent compound called curcumin to label and detect retinal plaques. This is believed to be the first use of curcumin as an imaging agent to detect Alzheimer's disease-related plaques in the retinas of live animals. Curcumin, a natural component of the spice turmeric, binds to beta-amyloid plaques and makes them visible when viewed microscopically. In the Cedars-Sinai research, curcumin injected into the bloodstream of live mice crossed the blood-retinal barrier and specifically bound to the retinal plaques, allowing them to be viewed in high resolution with a noninvasive procedure.
  4. Observations from multiple genetically engineered mouse models of Alzheimer's disease demonstr
    '/>"/>

Contact: Sandy Van
sandy@prpacific.com
808-526-1708
Cedars-Sinai Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Hallmark Insights' Employer Survey Reveals Cost-Savings Benefits of Health & Wellness Programs
2. Hallmark Insights Completes SAS 70 Type II Audit
3. Blood stem-cell transplant regimen reverses sickle cell disease in adults
4. New research identifies modifiable risk factors for heart disease
5. Distinct demographic profiles between Crohns disease and ulcerative colitis
6. Summit Medical Group hosts “Go Red Day” to Raise Awareness of Heart Disease and Stroke
7. Keenan Selects Nurtur and Healthyroads for Integrated Disease Management and Personal Wellness Programs
8. Michael J. Fox Foundation Awards $2.8 Million to Drive Development of Parkinsons Disease Biomarker Pipeline
9. Tests showing smokers their individual risk of future disease will help them quit, says paper
10. Researcher to track spread of disease, malware and power outages
11. Texas Health Dallas Launches Screening Program for Female Heart Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2015)... FL (PRWEB) April 28, 2015 Two ... System were named to Becker's Hospital Review’s list ... . Peter Pronovost, M.D., Ph.D. , director of ... and senior vice president for patient safety and ... M.D., M.H.C.M. , vice president of medical affairs and ...
(Date:4/28/2015)... BC (PRWEB) April 28, 2015 Vancouver ... a blog stating that it is smarter to call ... a personal injury claim. The blog reasons that there ... since these professional are well-versed with the law and ... client would be able to on their own. Competent ...
(Date:4/28/2015)... 28, 2015 The popular all-natural supplement ... for their newly launched L-Style Revolution Program™, and collectively ... counting in just two short months. The customized ... exercise plan for men and women of all health ... loss and weight maintenance goals faster than traditional methods. ...
(Date:4/28/2015)... April 28, 2015 MSA Executive ... executive search, announced today that it has been retained ... Operating Officer search for The Queen's Health ... Reporting to QHS President & CEO Arthur A. Ushijima, ... have operating responsibility for the Queen’s Medical Center Punchbowl ...
(Date:4/28/2015)... Pittsburgh, PA (PRWEB) April 28, 2015 ... by Blair A. Jobe, MD, FACS , has ... replacing esophageal tissue with extracellular matrix (ECM) can help ... lethal form of esophageal cancer. , ECM is a ... for cell attachment and migration and signals that guide ...
Breaking Medicine News(10 mins):Health News:Johns Hopkins Medicine and All Children’s Hospital Leaders Recognized as Top Experts in Patient Safety 2Health News:Johns Hopkins Medicine and All Children’s Hospital Leaders Recognized as Top Experts in Patient Safety 3Health News:Johns Hopkins Medicine and All Children’s Hospital Leaders Recognized as Top Experts in Patient Safety 4Health News:Vancouver Personal Injury Lawyers Recently Stated in Latest Blog That It Is Smarter To Call A Lawyer Before ICBC 2Health News:Sports Nutrition Supplement Brand, Liporidex, Is Making History With Its New L-Style Revolution Diet & Exercise Program Reaching Over 10,000 Pounds Lost In Two Months 2Health News:Sports Nutrition Supplement Brand, Liporidex, Is Making History With Its New L-Style Revolution Diet & Exercise Program Reaching Over 10,000 Pounds Lost In Two Months 3Health News:The Queen’s Health Systems Retains MSA Executive Search to Recruit Executive Vice President & Chief Operating Officer 2Health News:Allegheny Health Network Launches First U.S. Clinical Trial of Extracellular Matrix as Replacement for Pre-Cancerous Tissue 2Health News:Allegheny Health Network Launches First U.S. Clinical Trial of Extracellular Matrix as Replacement for Pre-Cancerous Tissue 3
... health, , THURSDAY, Feb. 18 (HealthDay News) -- New research ... a lot and those who have them less often: The ... more depressed. , The finding comes from a study ... episodic, if they occurred no more than 14 days a ...
... ... than later, says substance abuse expert Glenn Williams in his new Authentic/Biblica book, Talking Smack ... (PRWEB) February 18, 2010 ... COO Glenn Williams, a psychologist and substance abuse expert who has worked with parents and ...
... ... Carnie Wilson, will host a blog on The Fresh Diet, chronicling her quest to whittle ... Corner at blog.thefreshdiet.com where the daughter of the legendary Beach Boy, Brian Wilson, will discuss ... , ...
... ... related Q&A and social networking site, grows and adds new offerings, including answer customization ... ... SciAnswers.com , launched just over three months ago in November 2009 as a science ...
... ... freight import records from the public. Meanwhile, Microsoft, Google and Sony continue to import ... ... 17, 2010 -- Trade Privacy LLC , a trade data protection company, just ...
... , , , ... Ensign Group, Inc. (Nasdaq: ENSG ), the parent company of ... and assisted living companies, today reported record results for the fourth ... , Financial Highlights Include: , Total ...
Cached Medicine News:Health News:Talking Smack to Keep Kids Drug-Free 2Health News:Talking Smack to Keep Kids Drug-Free 3Health News:Carnie Wilson Blogs On The Fresh Diet 2Health News:SciAnswers.com Grows and Adds a Technical and Healthcare Professionals Job Board. 2Health News:SciAnswers.com Grows and Adds a Technical and Healthcare Professionals Job Board. 3Health News:Trade Privacy LLC: Research Concludes Apple Inc. Has Blocked Their Import Records from Public Access 2Health News:The Ensign Group Reports Fourth Quarter 2009 Adjusted Earnings of $0.43 Per Share; Issues 2010 Guidance 2Health News:The Ensign Group Reports Fourth Quarter 2009 Adjusted Earnings of $0.43 Per Share; Issues 2010 Guidance 3Health News:The Ensign Group Reports Fourth Quarter 2009 Adjusted Earnings of $0.43 Per Share; Issues 2010 Guidance 4Health News:The Ensign Group Reports Fourth Quarter 2009 Adjusted Earnings of $0.43 Per Share; Issues 2010 Guidance 5Health News:The Ensign Group Reports Fourth Quarter 2009 Adjusted Earnings of $0.43 Per Share; Issues 2010 Guidance 6Health News:The Ensign Group Reports Fourth Quarter 2009 Adjusted Earnings of $0.43 Per Share; Issues 2010 Guidance 7Health News:The Ensign Group Reports Fourth Quarter 2009 Adjusted Earnings of $0.43 Per Share; Issues 2010 Guidance 8Health News:The Ensign Group Reports Fourth Quarter 2009 Adjusted Earnings of $0.43 Per Share; Issues 2010 Guidance 9Health News:The Ensign Group Reports Fourth Quarter 2009 Adjusted Earnings of $0.43 Per Share; Issues 2010 Guidance 10Health News:The Ensign Group Reports Fourth Quarter 2009 Adjusted Earnings of $0.43 Per Share; Issues 2010 Guidance 11Health News:The Ensign Group Reports Fourth Quarter 2009 Adjusted Earnings of $0.43 Per Share; Issues 2010 Guidance 12Health News:The Ensign Group Reports Fourth Quarter 2009 Adjusted Earnings of $0.43 Per Share; Issues 2010 Guidance 13Health News:The Ensign Group Reports Fourth Quarter 2009 Adjusted Earnings of $0.43 Per Share; Issues 2010 Guidance 14Health News:The Ensign Group Reports Fourth Quarter 2009 Adjusted Earnings of $0.43 Per Share; Issues 2010 Guidance 15Health News:The Ensign Group Reports Fourth Quarter 2009 Adjusted Earnings of $0.43 Per Share; Issues 2010 Guidance 16
(Date:4/28/2015)...  Perrigo Company plc (NYSE: PRGO ; TASE) ... quarterly dividend of $0.125 per share, payable on June 16, ... From its beginnings as a packager ... headquartered in Ireland , has grown ... manufactures and distributes over-the-counter (OTC) and generic prescription (Rx) ...
(Date:4/28/2015)... 2015 Konica Minolta Medical Imaging Americas ... for fiscal year ended March 31, 2015, led ... Primary Imaging Solutions.  The success of the wireless ... double digit sales figures exceeding expectations.  The AeroDR ... XE, a wireless flat panel detector, specially engineered ...
(Date:4/28/2015)... , April 28, 2015 UPM Pharmaceuticals, ... was awarded the prestigious "2015 Industry Choice Award" in ... presented by Life Science Leader magazine during ... New York City on March ... honor top performing service organizations based on survey responses ...
Breaking Medicine Technology:Konica Minolta Sets Record Digital Radiography Sales 2UPM Pharmaceuticals Awarded The 2015 Industry Choice Award for Mid-sized and Emerging Pharma 2
... 2011 CardioMEMS, Inc ., an Atlanta-based medical ... proprietary wireless sensing and communication technology for the human ... Yadav, M.D., was presented with a Health-Care Heroes Award ... Business Chronicle.  The award was conferred on Dr. Yadav ...
... 2011 CardioGenics Holdings Inc. (CGNH: OTCB) announced today ... presenting at the 7th Annual Spring Growth Stock Conference ... be held on Tuesday, May 24th at the Omni ... will include a select group of institutional portfolio managers ...
Cached Medicine Technology:CardioMEMS Founder Dr. Jay Yadav Honored With Health-Care Heroes Award by the Atlanta Business Chronicle 2CardioMEMS Founder Dr. Jay Yadav Honored With Health-Care Heroes Award by the Atlanta Business Chronicle 3CardioGenics to Present at the 7th Annual Spring Growth Stock Conference Hosted by Security Research Associates, Inc. 2CardioGenics to Present at the 7th Annual Spring Growth Stock Conference Hosted by Security Research Associates, Inc. 3
... Introducing the new large ... new handpieces function as both ... the ultimate in flexibility. Its ... always wanted with the security ...
... 7600 Oscillating Saw offers unparalleled ... thanks to its 14.4V NiMH ... head may be rotated into ... any plane and will accept ...
... Breakthrough in Battery Powered Orthopedic Systems., ... new addition to the Hall® Surgical line ... System is the first and only software ... market. It is a full-function orthopedic power ...
... Introducing the new large ... Our new handpieces function ... electric instruments, offering the ... the versatility the industry ...
Medicine Products: