Navigation Links
Half-matched transplants widen pool of donors for leukemia and lymphoma
Date:7/7/2011

dvanced disease or at high risk for relapse were included in each of the Phase II trials. Six of the participating centers conducted both types of transplants. Johns Hopkins conducted the haploidentical transplant trial only.

Transplants with cord blood, collected from the umbilical cord and placenta after a baby is born, are generally done in children because of the small number of cells in a single unit of cord blood. Adults, on the other hand, need two units.

Bone marrow tissue is extracted by needle from the hip bone of donors. Marrow that is half-identical to a patient's tissue type can be obtained from parents, children and most siblings.

Results of the two trials show one-year survival rates of 54 percent for cord blood transplant and 62 percent for haploidentical marrow. Survival without disease progression at one year was 46 percent for cord blood and 48 percent for haploidentical marrow. The investigators say this is comparable to survival achieved by similar patients undergoing transplants from fully matched siblings or unrelated adult donors.

Relapse rate after one year was 45 percent for haploidentical marrow transplants and 31 percent for cord blood. No patients had severe graft versus host disease (GVHD) an attack on the patient's normal tissues by immune cells of the donor -- after bone marrow transplant.

At one year, deaths not caused by relapse occurred in seven percent of haploidentical patients and 24 percent of cord blood transplants.

Fuchs says that in the past, haploidentical transplants failed more often because the transplanted cells caused severe GVHD, especially in older patients. Half of the patients enrolled in the current trials were 50 and older.

"Ten years ago, it was unthinkable to do a haploidentical transplant," says Fuchs, who led the haploidentical transplant clinical trial.

To overcome the GVHD problems, Fuchs and colleagues at the Johns Hopkins Bon
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Internal Anthem Blue Cross/WellPoint Document: Only Patients Who Push Back Get Covered Out of State Liver Transplants
2. Los Angeles Hair Transplant Cosmetic Surgeon Corrects Bad Hair Transplants With New Hair Restoration Method
3. Kidney transplants: Expanding the pool of available organs
4. Patients with treatment-resistant CLL respond positively to stem cell transplants
5. Hispanics and Asians less likely to receive liver transplants
6. Biosynthetic Corneas Show Promise in Transplants
7. OHSU research suggests compound administered during some bone marrow transplants elevates risks
8. Kidney Transplants for Elderly Double Over Decade
9. HIV Patients Do Well After Kidney Transplants: Study
10. 2 people receive kidney transplants in pilot program using CMU software
11. Gene protects lung from damage due to pneumonia, sepsis, trauma, transplants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... , ... August 29, 2015 , ... ... insufficient scrotal support and protection against dribbled urine and sweat. "In order to ... Hills, N.Y. , The EASY ACCESS DRYNESS ENHANCED MEN'S UNDERGARMENT provides optimal support ...
(Date:8/29/2015)... Aliso Viejo, CA (PRWEB) , ... August 29, 2015 , ... ... Cut Pro X . Each preset contains 15 seconds of unique footage that users ... presets that rise, fall, zoom, attract and more. Users can customize color, brightness, scale, ...
(Date:8/28/2015)... ... ... Rio Salado College joined nine educational institutions in Washington D.C., ... EDUCAUSE - Next Generation Learning Challenges 2015 Breakthrough Models Incubator funded by the ... Incubator hosted by EDUCAUSE and NGLC, which is designed to bring leadership teams ...
(Date:8/28/2015)... ... ... An article published August 19th by the LA Times documented ... open a pizzeria in Westchester. Mr. LaRocco was aware from opening prior pizza parlors ... current process, having already gone on for over a year, is taking much longer ...
(Date:8/28/2015)... , ... August 28, 2015 , ... The 6th ... renowned Brain Aneurysm Foundation has added yet another accolade to its cadre of widespread ... , “With the help of the medical community and the University of ...
Breaking Medicine News(10 mins):Health News:Modified Men’s Underwear Promote More Comfort and Hygiene - Designed by InventHelp Client (LGI-1968) 2Health News:FCPX Effects Developer, Pixel Film Studios, Releases ProDrop Particles. 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 3Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 4Health News:Article on Building Approval Process for LA Business Highlights the Need for a Bridge Between Businesses and City Officials, says Fire Protection Group Inc. 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 3
... Dec. 18 Many large companies depend,on successful ... portfolio. These alliances are developed to achieve common ... deals to tap into expertise of small biotech ... development expertise, and market,insight to the smaller companies., ...
... Art Mellor is one of,more than 400,000 people in ... (MS). It,s, a debilitating disease that causes,paralysis, blindness, incontinence ... that Mellor, the founder of the Accelerated,Cure Project for ... in raising the funds he needs to scratch "Develop ...
... over their daily activities and do challenging work they enjoy ... new study from The University of Texas at Austin published ... "The most important finding is that creative activity helps people ... with the Population Research Center at The University of Texas ...
... jeopardize further breakthroughs: report , , TUESDAY, Dec. 18 (HealthDay ... treatments for liver, kidney, head and neck and lung ... cancer care, the American Society of Clinical Oncology says ... while treatment is improving the lives of many cancer ...
... Cytopia,s first Phase II clinical trial, MELBOURNE, Australia, ... approval to proceed with a Phase II clinical,study assessing ... myeloma,patients. Patient enrolment will soon commence., This Phase ... further clinical,studies planned for the anti-cancer vascular-disrupting agent CYT997 ...
... Whether enjoying a meal at,home, at work or on ... don,t want to sacrifice great taste ... or convenience. ... leader in the frozen sandwich category has,found the solution. ... whole grains in every bite with seven delicious varieties ...
Cached Medicine News:Health News:Developing Excellence in Alliance 2Health News:This Holiday Season Some Dream of a White Christmas - The Accelerated Cure Project Dreams of Developing a Cure for Multiple Sclerosis 2Health News:This Holiday Season Some Dream of a White Christmas - The Accelerated Cure Project Dreams of Developing a Cure for Multiple Sclerosis 3Health News:Creative work has health advantages, Population Research Center study shows 2Health News:Cancer Care Advances in 2007 Offer Hope 2Health News:Cancer Care Advances in 2007 Offer Hope 3Health News:Cancer Care Advances in 2007 Offer Hope 4Health News:Cytopia Commences Phase II Cancer Drug Study 2Health News:Cytopia Commences Phase II Cancer Drug Study 3Health News:A Whole New Sandwich Debuts in the Freezer Aisle: LEAN POCKETS(R) Brand Introduces Latest Whole Grain Varieties 2Health News:A Whole New Sandwich Debuts in the Freezer Aisle: LEAN POCKETS(R) Brand Introduces Latest Whole Grain Varieties 3
(Date:8/28/2015)... , Aug. 28, 2015 ... the addition of the "Investigation Report on China,s ... Tobramycin is a traditional antibiotic whose eye drop ... the treatment of potential infection or inflammation caused by ... China are able to produce tobramycin, among ...
(Date:8/28/2015)... , Aug. 28, 2015 ... announced the addition of the "Investigation Report ... their offering. Developed by Pharmacia & ... receptor agonist which effectively reduces intraocular pressure. As ... latanoprost (under the trade name of Xalatan) entered ...
(Date:8/28/2015)... , Aug. 28, 2015  Perrigo Company plc ... it has completed the acquisition of leading OTC brands ... €200 million. The transaction is a clear demonstration of ... Company,s leading European distribution network spanning 36 countries.  ... C. Papa commented, "We are excited to complete ...
Breaking Medicine Technology:Investigation Report on China's Tobramycin Market, 2015-2019 2China Latanoprost Market Investigation Report 2015-2019 2Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 2Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 3Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 4
... management in the biopharmaceutical industry will "redouble efforts at ... intellectual property theft, counterfeiting and piracy, along with real ... a resolution unanimously adopted by the trustees ... the group applauds the ongoing efforts by labor and ...
... Inc. (NASDAQ: IDIX ), announced today that Idenix ... Life Sciences Conference on September 21, 2011 at 2:00 p.m. ... The live and archived webcast of the company ... Idenix Investor Center at www.idenix.com . Please log in ...
Cached Medicine Technology:PILMA Vows to 'Redouble' Support for Increased Protections Against Intellectual Property Theft 2
... Gentian violet ink stands ... Millimeter scale ruler printed ... for quick measuring. Flexible, ... both inch and metric ...
Freer elevator, double end, 7 1/4", S/B....
Stainless steel dull finish....
The Ultima 2000 SE is flexible in meeting the needs of both office and operating room use. It is the answer for the clinical practice with a wide range of ophthalmic demands looking for minimal risk ...
Medicine Products: