Navigation Links
'Half-match' bone marrow transplants wipe out sickle cell disease in selected patients
Date:9/20/2012

plant candidate had experienced many severe pain crises, significant organ problems, or had failed hydroxyruea, the only drug known to curtail sickle cell symptoms. The team found donors for 17 of the 19 patients: 14 were half-identical and three were fully matched siblings. The youngest patient was 15; the oldest 46.

Before each transplant, sickle cell patients received a "conditioning" regimen of low-dose immunosuppression drugs, low toxicity chemotherapy, and low-dose total body irradiation. Brodsky says this gentler approach to pre-transplant therapy has made transplant possible for sickle cell patients whose tissues and organs have been ravaged by the disease.

After the transplant, all patients received high doses of the chemotherapy drug cyclophosphamide, which kills remaining blood cells, including diseased sickled cells, and preserves the donor's stem cells responsible for making new, healthy cells.

Of the 17 patients, six transplants were not successful; however, because of the reduced intensity of the conditioning regimen, all of these patients recovered their own blood cells.

There were no deaths, some infections, and only slight skin-related graft versus host disease symptoms in one patient, which cleared without therapy, the researchers reported. Some brain swelling occurred in three patients during the conditioning period and resolved without neurologic damage.

The Johns Hopkins doctors say that while the majority of patients in the trial had successful transplants, about less than half did not.

"Sickle cell disease patients undergo multiple blood transfusions throughout their lives and may have acquired antibodies against many different blood types, making it more difficult than usual to give patients donated bone marrow." says Javier Bolaos-Meade, M.D., associate professor of oncology at the Johns Hopkins Kimmel Cancer Center and principal investigator of the study.

Improving the rate
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Lack of sleep affects bone health and bone marrow activity
2. New genetic clues to why most bone marrow transplant patients develop graft-versus-host disease
3. HIV Undetectable in 2 Men After Bone Marrow Transplants: Study
4. Bone marrow transplant eliminates signs of HIV infection
5. Clinical trial seeks to cure advanced Crohns disease using bone marrow transplant
6. HIV drug reduces graft-vs.-host disease in bone marrow transplant patients, Penn study shows
7. HIV Drug May Prevent Bone Marrow Transplant Complication
8. Markey receives $6.25 million to study deadly blood and bone marrow disease
9. Fertilizing bone marrow helps answer why some cancers spread to bones
10. Noninvasive imaging technique may help kids with heart transplants
11. Protecting the hearts of those waiting for kidney and liver transplants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... At the end of February 2015, Choices ... to the Oscars” in the Stardust Penthouse on the ... impressive Los Angeles skyline. These events honoring the 2015 ... leading producer of sustainable product placement in TV and ... providers of eco-friendly and socially conscious products and services, ...
(Date:4/17/2015)... Organic Valley, the nation’s largest cooperative of ... Year of Soils by “Cycling for Sustainability” through California ... will travel 215 miles from Auburn, California, to the ... the impact of agriculture on water and soil in ... Wisconsin, Oregon, and Washington state, the cyclists have diverse ...
(Date:4/17/2015)... Calvary Hospital recently announced Timothy P. Barr ... President on May 11. The Fund directs all fundraising efforts ... succeeds Vincent J. Spinelli, who retired several months ago. , ... and supervise the important work that the Fund does every ... continues to expand and bring our signature care to people ...
(Date:4/17/2015)... Lowcostcarinsuranceprice.com has released a new blog post explaining the ... car insurance rates . , Falling asleep at ... have a big impact on auto insurance prices. The premiums ... claimed benefits. The newly released blog post talks more about ... , It is now possible to find low cost ...
(Date:4/17/2015)... Wholelifelifeinsurance.org has released a new blog post ... policies . , Whole life insurance can help ... families at the same time. Whole life insurance is ... customized to it the client’s needs. , Whole ... some appropriate steps.Comparing life insurance quotes is very important ...
Breaking Medicine News(10 mins):Health News:Choices Recovery Speaks with Dakota Hood of “The Hunger Games” about Addiction in Hollywood 2Health News:Organic Valley Farmers and Employees "Cycling for Sustainability" Through 215 Miles of California Watershed April 19-25 2Health News:Organic Valley Farmers and Employees "Cycling for Sustainability" Through 215 Miles of California Watershed April 19-25 3Health News:Timothy P. Barr Appointed Executive Vice President of Calvary Fund 2Health News:Timothy P. Barr Appointed Executive Vice President of Calvary Fund 3Health News:Accidents Caused By Sleeping at The Wheel Can Increase Auto Insurance Costs 2Health News:Whole Life Insurance Policies At Affordable Prices By Comparing Quotes 2
... 21 The Hispanic got milk? Milk Mustache Mobile,Drink Well. ... tour, including,the top 10 Hispanic cities, to reintroduce Hispanics to ... cruised through Denver,hosting free events to encourage local residents to ... drink -- milk. , At the ...
... are government agencies and media -- , FLEMINGTON, N.J., ... among 688 physicians revealed that over the past few ... impact that the H1N1 swine flu will have on ... )The study was conducted last night ...
... fewer signs of condition , , THURSDAY, May 21 (HealthDay News) ... has been identified by U.S. researchers, who said their finding ... , The researchers found that mice without the ion channel ... to normal mice, those lacking the gene for TRPA1 had ...
... HILLS, N.J., May 21 The Christopher & ... to finding cures and treatments for spinal cord ... with paralysis, announced today it has received a ... arm, the TD Charitable Foundation. The donation ...
... Sensors for Medicine and Science, Inc., a ... could dramatically improve continuous glucose monitoring for people ... $10 million financing with a strategic investor. ... existing Series C preferred stock. No product ...
... Gulf Coast Medical Center,s Average ER Wait TimePANAMA CITY, Fla., ... Panama City, FL area to find out the average ER ... to the hospital. The hospital is posting its average ... this year, we became the only hospital in our area ...
Cached Medicine News:Health News:The Hispanic got milk? Campaign Visited Denver May 17th - May 20th 2Health News:Physicians are Less Concerned about H1N1 Swine Flu 2Health News:Physicians are Less Concerned about H1N1 Swine Flu 3Health News:Physicians are Less Concerned about H1N1 Swine Flu 4Health News:Christopher & Dana Reeve Foundation Receives $25,000 Gift from TD Bank 2Health News:Christopher & Dana Reeve Foundation Receives $25,000 Gift from TD Bank 3Health News:ER Wait Times at Your Fingertips 2
(Date:4/16/2015)... , April 16, 2015 Mindray ... developer, manufacturer, and marketer of medical devices worldwide, ... Securities and Exchange Commission an Annual Report on Form ... year ended December 31, 2014. An electronic version of ... on Mindray,s investor relations website at  http://ir.mindray.com  or  ...
(Date:4/16/2015)... April 16, 2015  Hologic, Inc. (NASDAQ: ... screening study i published on-line this week ... of the American Cancer Society. The ... of Pittsburgh Medical Center, supports current consensus guidelines ii ... women 30-65 years of age be co-tested with ...
(Date:4/16/2015)... 16, 2015  Amgen (NASDAQ: AMGN ) today ... results on Tuesday, April 21, 2015, after the close ... followed by a conference call with the investment community ... Amgen will be Robert A. Bradway , chairman ... senior management team. Live audio of the ...
Breaking Medicine Technology:Mindray Files Annual Report on Form 20-F with the U.S. Securities and Exchange Commission 2Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 2Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 3Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 4Amgen Announces Webcast Of 2015 First Quarter Financial Results 2
... UBM Conferences , a division of UBM Plc ... Extractables and Leachables Webinar to be hosted on May ... to attend webinar will evaluate the considerations to be ... development, in addition to highlighting how monomers and additives, ...
... ARBOR, Mich., May 16, 2012  Rubicon Genomics, Inc., ... sample-specific pre-analytical processes to improve the performance and ... research and clinical testing, today announced the launch ... family of sample preparation kits designed and optimized ...
Cached Medicine Technology:Global Webinar Focuses on Considerations for Extractables and Leachables 2Rubicon Genomics Launches ThruPLEX™ Family of Sample Preparation Products for Next Generation Sequencing Applications 2Rubicon Genomics Launches ThruPLEX™ Family of Sample Preparation Products for Next Generation Sequencing Applications 3
... for Unparalleled Comfort Pick one of our ... Notice the trigger and ejector positionsright where they ... pipettors are ergonomically designed to help avoid repetitive ... Productivity In The Palm Of Your Hand ...
... Ergonomic Design for Unparalleled Comfort ... it. Notice the balance. Notice the trigger and ... left-handed. Thats because our pipettors are ergonomically designed ... long hours of pipetting. Productivity In The ...
... ergonomic solution and best value in high ... action and ultra lightweight design reduce hand ... with long, lever tip ejector , Color ... universal tips or for greater performance use ...
... Finnpipette BioControl multichannel has ... as the single channel ... fits allseven multichannel and ... cone modules. Both pipettes ...
Medicine Products: