Navigation Links
'Half-match' bone marrow transplants wipe out sickle cell disease in selected patients
Date:9/20/2012

Treatments include blood transfusions and a drug, hydroxyurea. Many patients use narcotics to control severe pain and have repeat hospitalizations. Bone marrow transplants have been successful in curing some cases, but matching donors are rare and the procedure itself poses risk.

In the current study, 17 patients at the Johns Hopkins Hospital were offered bone marrow transplant options, including the use of half-matched donor marrow to try and replace their "sickled" blood cells with new, healthy ones. The transplants were successful in 11 of the patients, of whom eight were only half-matches. Results of the trial were published in the Sept. 6 early online edition of Blood.

"We're trying to reformat the blood system and give patients new blood cells to replace the diseased ones, much like you would replace a computer's circuitry with an entirely new hard drive," says Robert Brodsky, M.D., director of the Division of Hematology at Johns Hopkins and The Johns Hopkins Family Professor of Medicine and Oncology. "While bone marrow transplants have long been known to cure sickle cell disease, only a small percentage of patients have fully matched, eligible donors."

National registries often are of little help in finding donors for sickle cell patients, because most of those in need are African American and other minorities who are vastly underrepresented in registries, say the Johns Hopkins researchers.

To overcome the shortage of donors, investigators at Johns Hopkins developed techniques, recently tested in leukemia and lymphoma patients, to transplant with bone marrow that is half-identical or "haploidentical" to the patient's tissue type. Half-matched bone marrow can be obtained from parents, children and most siblings, and is extracted by needle from the hip bone.

For the study, the Johns Hopkins team screened 19 patients to find bone marrow donors with either half-identical or fully matched tissue. Each trans
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Lack of sleep affects bone health and bone marrow activity
2. New genetic clues to why most bone marrow transplant patients develop graft-versus-host disease
3. HIV Undetectable in 2 Men After Bone Marrow Transplants: Study
4. Bone marrow transplant eliminates signs of HIV infection
5. Clinical trial seeks to cure advanced Crohns disease using bone marrow transplant
6. HIV drug reduces graft-vs.-host disease in bone marrow transplant patients, Penn study shows
7. HIV Drug May Prevent Bone Marrow Transplant Complication
8. Markey receives $6.25 million to study deadly blood and bone marrow disease
9. Fertilizing bone marrow helps answer why some cancers spread to bones
10. Noninvasive imaging technique may help kids with heart transplants
11. Protecting the hearts of those waiting for kidney and liver transplants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2015)... (PRWEB) , ... August 30, 2015 , ... ... Ultrasound (HIFU) medical devices for the treatment of prostate cancer, has announced the ... this summer at the treatment center in Puerto Vallarta, Mexico. , The Sonablate® ...
(Date:8/29/2015)... ... August 29, 2015 , ... ... inventors from Miller Place, N.Y. "I specialize in manual therapy, and my invention ... it can be used for additional muscle dysfunction throughout the body." , They ...
(Date:8/29/2015)... NY (PRWEB) , ... August 29, 2015 , ... Next ... end of summer (which astronomically, officially ends on September 22nd this year). For IT ... cyber security hangovers linger on which could prove far more costly than a simple ...
(Date:8/29/2015)... ... 2015 , ... Vascular Health Sciences announced today that an ... HP, and that all claims and counterclaims have been irrevocably dismissed. , In ... the United States District Court for the Southern District of Texas for breach ...
(Date:8/28/2015)... ... August 28, 2015 , ... The Kentucky State Department of Workforce Investment ... position they are applying for, they are unable to pass the initial drug test ... drug testing policies in order to be able to hire long-term, skilled talent. (1) ...
Breaking Medicine News(10 mins):Health News:Image Fusion Technology Combines MRI and Ultrasound Images to Treat Prostate Cancer 2Health News:Inventors and InventHelp Clients Develops Tension Reliever (LGI-1951) 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 3Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 4Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 2Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 3Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 4
... MADISON - For the millions of Americans whose vision is ... lowly neural progenitor// cell may be riding to the rescue. ... derived from human fetal stem cells have been shown to ... to the kinds of diseases that afflict humans. The new ...
... Diabetes and high blood pressure, two conditions rooted in ... than race alone in determining// who is mostly likely ... from cardiologists at Johns Hopkins. Each year, nearly 300,000 ... ,Experts say that racial disparities have long been known ...
... lawmakers Monday it could be a decade or more before ... drugs // in the way the agency approves knockoffs of ... Janet Woodcock's testimony could benefit companies such as Amgen Inc. ... the U.S. for their products, some of the most complex ...
... blood thinner, one of the first signs the drug is ... and bruising,// an inconvenient side effect of preventing the blood ... stroke. While potentially life-saving, the drugs can also pose a ... of blood levels. ,So when he didn’t see ...
... disease causing tennis-ball-size ulcers so painful that victims feel ... than two years// become the second illness after smallpox ... and other preventive methods, the United Nations health agency ... of years of effort by local and international groups ...
... secretary said that computer based therapy will be available ... will be available to all patients in England from ... Beating the blues have been designed as therapies for ... warned that computer aided programs may not be suitable ...
Cached Medicine News:Health News:Stem Cell Therapy Shows Promise for Rescuing Deteriorating Vision 2Health News:Stem Cell Therapy Shows Promise for Rescuing Deteriorating Vision 3Health News:Who Gets Heart Failure? Race Takes Back Seat to Diabetes and High Blood Pressure 2Health News:Who Gets Heart Failure? Race Takes Back Seat to Diabetes and High Blood Pressure 3Health News:FDA Cites Challenges of Generic Biotech 2Health News:New Blood Thinner May Work Without Bleeding Risk 2Health News:Ancient Worm Disease Could Be Eradicated Within Two Years, UN Agency Reports 2Health News:Computer Based Therapy For Depression 2
(Date:8/27/2015)... FRANKLIN, Mass. , Aug. 27, 2015 /PRNewswire/ ... in the KSSTA Knee Journal, compared the Arthrosurface ... "inlay" Arthroplasty design, versus an "onlay" design implant ... showed similar improvements in function and pain scores, ... showed progression of osteoarthritis (OA). However, 53% of ...
(Date:8/27/2015)... Aug. 27, 2015 Biosimilars are not ... the U.S. Food and Drug Administration (FDA) for ... in its draft guidance issued today. The FDA,s ... proposes distinguishable names, calling for biological products to ... suffix. This proposal reflects the agency,s thinking that ...
(Date:8/27/2015)... , August 27, 2015 According to ... (Transfer, Hammock, Toilet, Seating, Universal, Standing, Bariatric ), Material (Nylon, Padded, ... Forecast to 2020", published by MarketsandMarkets, the Medical Lifting Sling Market ... 411.5 Million in 2015, at a CAGR of 11.4 % from ... ma rket data T ables and ...
Breaking Medicine Technology:Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 2Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 3Biologics Prescribers Collaborative (BPC) Statement on FDA Draft Guidance entitled "Nonproprietary Naming of Biological Products" 2Medical Lifting Sling Market Worth USD 706.0 Million by 2020 2Medical Lifting Sling Market Worth USD 706.0 Million by 2020 3Medical Lifting Sling Market Worth USD 706.0 Million by 2020 4
... Failed to Reach Statistical ... ... /PRNewswire-,FirstCall/ -- United Therapeutics Corporation (Nasdaq: UTHR ) and its,wholly- ... pivotal trials of OvaRex(R) MAb for the,treatment of advanced ovarian cancer. ...
... Cancer Patients, ROCKVILLE, Md., Dec. 4 ... company developing,therapeutics for the treatment of cancer and ... multi-center Phase 2 clinical trial with,MKC-1 in patients ... study will be to determine the antitumor activity ...
Cached Medicine Technology:Clinical Studies of OvaRex in Advanced Ovarian Cancer Fail to Meet Primary Endpoint 2Clinical Studies of OvaRex in Advanced Ovarian Cancer Fail to Meet Primary Endpoint 3Clinical Studies of OvaRex in Advanced Ovarian Cancer Fail to Meet Primary Endpoint 4EntreMed Commences Phase 2 Study with MKC-1 in Pancreatic Cancer 2EntreMed Commences Phase 2 Study with MKC-1 in Pancreatic Cancer 3EntreMed Commences Phase 2 Study with MKC-1 in Pancreatic Cancer 4
... VasoSeal VHD was the ... stop bleeding after diagnostic ... radiology procedures. It is ... device approved for immediate ...
... Hemostats First Stop absorbable collagen hemostat. FirstStop ... superior handling and removal characteristics. It can ... to fit the wound. FirstStop products are ... be peeled away after hemostasis is achieved. ...
The VasoSeal Low Profile device is designed for smaller sheath angiography procedures. VasoSeal Low Profile. Seal your arterial punctures with confidence....
The VasoSeal Low Profile device is designed for smaller sheath angiography procedures. VasoSeal Low Profile. Seal your arterial punctures with confidence....
Medicine Products: