Navigation Links
'Half-Match' Marrow Transplants Help Some With Sickle Cell
Date:9/21/2012

By Alan Mozes
HealthDay Reporter

FRIDAY, Sept. 21 (HealthDay News) -- In what might one day prove to be a breakthrough for those suffering from sickle cell anemia, new research suggests that bone marrow transplants based on partially matched donors can, in some cases, turn out as well for patients as fully matched transplants.

But, the finding is based on a very small study involving just 17 patients, and was described as "preliminary" in nature.

Still, with fully matched donors in drastically short supply, the notion that so-called "half-matched" transplants might also work raises the possibility that many more patients could avail themselves of a treatment for what can be an extremely painful, debilitating and ultimately fatal illness.

"We're trying to reformat the blood system and give patients new blood cells to replace the diseased ones, much like you would replace a computer's circuitry with an entirely new hard drive," study author Dr. Robert Brodsky, director of the division of hematology at Johns Hopkins and the Johns Hopkins Family Professor of Medicine and Oncology in Baltimore, said in a university news release.

"[But] while bone marrow transplants have long been known to cure sickle cell disease, only a small percentage of patients have fully matched eligible donors," he added.

Brodsky and his colleagues discussed the donor dilemma and their efforts to broaden transplant options in the Sept. 6 online edition of the journal Blood.

Roughly 100,000 Americans live with sickle cell anemia, a genetic disorder that impedes the normal workings of hemoglobin molecules responsible for transporting oxygen within red blood cells. The stiffening and misshaping of such cells into the telltale form of a "sickle" ultimately leads to cell clumping. In the end, oxygen delivery to organs and tissues shuts down.

As the illness progresses, patients typically struggle with excruciating pain, along with a risk complications, including kidney failure, stroke, lung disease and blood clots. Many die of the disease before the age of 50.

Treatment is often centered around the use of narcotics for pain control, along with frequent blood transfusions and hospitalizations.

The good news: bone marrow transplants involving fully matched tissue donors have shown the potential to effect a cure in some patients.

The bad news: the vast majority of patients are black (with about one in every 400 blacks struck by the disease) and national donor registries are limited, leaving many to wait in vain for a donor match.

Brodsky and his team performed bone marrow transplants involving both fully matched donors (three cases) and half-matched donors (14 cases), among patients between 15 and 46 years of age.

Both full and partial donor matches were drawn from family members such as parents, children and/or siblings. And all patients underwent a comparatively "gentle" pre-procedure prep regimen of immuno-suppression, chemotherapy and radiation treatment, the study authors said.

The result: 11 of the 17 transplants were deemed "successful." And of these 11 patients, eight had undergone half-matched operations.

The study authors said there were no fatalities. They concluded that the half-matched approach appeared to produce a success rate greater than 50 percent.

Dr. Zora Rogers, clinical director of the General Hematology Program at the Children's Medical Center in Dallas, said that while the findings are "encouraging," they should be interpreted with caution.

"First of all," she said, "it's important to recognize that this half-matched procedure performed predominantly among adults was not as good as a fully matched transplant performed among children would be, where the cure rate exceeds 90 percent. In fact, when you look at the 11 patients they say got better, six of them, if you will, were really 'cured' of their disease, while the other five of them remained a mixture of someone with the disease and without."

"But more importantly," Rogers added, "I would also point out that what a success rate of a little bit over 50 percent means is that you could go through this very big deal transplant, put your life at risk, and have it fail about half the time. Now, sickle cell is a horrible disease. Don't get me wrong. But unlike in leukemia or other malignancies where a transplant is your only hope, with sickle cell it's just an option. So, for patients who wish to pursue a cure this may expand their choices. But they need to consider this information carefully."

More information

For more on sickle cell anemia, visit the U.S. National Library of Medicine.

SOURCE: Sept. 20, 2012, news release, Johns Hopkins, Baltimore


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Half-match bone marrow transplants wipe out sickle cell disease in selected patients
2. Fertilizing bone marrow helps answer why some cancers spread to bones
3. Markey receives $6.25 million to study deadly blood and bone marrow disease
4. HIV Drug May Prevent Bone Marrow Transplant Complication
5. HIV drug reduces graft-vs.-host disease in bone marrow transplant patients, Penn study shows
6. Clinical trial seeks to cure advanced Crohns disease using bone marrow transplant
7. Bone marrow transplant eliminates signs of HIV infection
8. HIV Undetectable in 2 Men After Bone Marrow Transplants: Study
9. New genetic clues to why most bone marrow transplant patients develop graft-versus-host disease
10. Lack of sleep affects bone health and bone marrow activity
11. First, Second Kidney Transplants Have Similar Success: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Half-Match' Marrow Transplants Help Some With Sickle Cell
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a ... utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will revolutionize the ... a CBD form that can be easily incorporated into liquid products, while reducing costs ...
(Date:10/13/2017)... QUEENS, N.Y (PRWEB) , ... October 13, 2017 , ... ... recently became a member of ElderCounsel, a national organization of elder law and special ... constantly changing laws and rules. It also provides a forum to network with elder ...
(Date:10/13/2017)... LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for care ... is the 90-day elimination period, when the family pays for care, is often waived, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional ... action towards gender equality at their inaugural Summit in New York City in June. ... a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at ... of the most popular and least understood books in the Holy Scriptures, Revelation. The ... that have baffled scholars for centuries. Many have tossed it off as mere rubbish, ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  True Health, a ... amplified its effort during National Breast Cancer Awareness ... cancer risks. ... Oncology calculated that more than 10 million American ... mutations in BRCA1 or BRCA2 and have not had ...
(Date:10/10/2017)... Pa. , Oct. 10, 2017   West ... in innovative solutions for injectable drug administration, today shared ... West,s ID Adapter for improving the intradermal administration of ... Fourth Skin Vaccination Summit in May 2017 by Dr. ... Lead, Polio Department, World Health Organization (WHO), and recently ...
(Date:10/4/2017)...  South Korean-based healthcare product Development Company I.M. Lab ... Kickstarter. The device will educate the user about ,proper, ... efficiency compared to the dated and pricey CPR training ... of the compression for a more informed CPR training. ... raise $5,000. cprCUBE ...
Breaking Medicine Technology: