Navigation Links
Half-Dose Flu Shot Works Well in Young Adults
Date:12/8/2008

The finding could greatly expand the supply of the seasonal vaccine, experts say

MONDAY, Dec. 8 (HealthDay News) -- A half-dose flu shot is sufficient to trigger an immune response in healthy adults younger than age 50 who've had prior flu vaccinations, U.S. researchers report.

The finding suggests that using half-doses in healthy young people may be a way of coping with vaccine shortages.

"Since 2002, optimum influenza vaccine delivery has been impaired as a result of supply shortages. With the abrupt loss of half the anticipated national influenza vaccine supply in October 2004, the option of using a reduced dose for immunization of healthy, high-priority groups became a critical consideration," Dr. Renata J.M. Engler, of Walter Reed Army Medical Center and colleagues wrote as background information in their study.

In a study involving healthy adults, aged 18 to 64, who'd been vaccinated within the past one to three years, Engler and colleagues gave a full-dose flu shot to 554 participants and a half-dose shot to 556 participants. Blood samples taken before and 21 days after vaccination were tested for antibodies against influenza and the volunteers reported any flu-like symptoms they experienced during this time period.

"Antibody responses to intramuscular half-dose trivalent inactivated influenza vaccine in healthy, previously immunized adults were not substantially inferior to the full-dose vaccine, particularly for ages 18 to 49 years," the researchers wrote.

The participants were given their flu shots between November and December 2004. Those who received the half-dose shot had no more medical visits for respiratory or cardiovascular reasons than those who received the full-dose flu shot.

The study is published in the Dec. 8/22 issue of the Archives of Internal Medicine.

"Given the benefits of immunizing healthy working adults and caregivers, these data support the validity of a dose reduction strategy in the setting of vaccine shortages," the researchers wrote. "Reduced dosing could have a significant impact on the response to vaccine shortages, particularly at a local level when faced with considerable delays in vaccine supply delivery."

Engler and colleagues also found that women of all ages had a greater immune response to both doses of the flu vaccine than men. Women who received the half dose had similar antibody responses as men who received the full dose.

"These findings suggest that guidelines for vaccine use during shortages should take sex, as well as age, into consideration. As recommendations for influenza expand and evidence that elderly persons [men older than 60 years] may require higher doses of vaccine for optimal responses, reduced doses in healthy, younger populations may become a valuable national strategy," the study authors concluded.

Instead of trying to find ways to stretch vaccine supplies, better methods of flu vaccine production are needed, Dr. Ann R. Falsey, of Rochester General Hospital, N.Y., said in an accompanying editorial.

"Although the results of this study are useful and can provide a guide to extending the vaccine supply during periods of shortage, perhaps the real message of this study is that better methods of influenza vaccine production that are less prone to problems are clearly needed," she wrote.

More information

The U.S. Centers for Disease Control and Prevention has more about preventing seasonal flu.



-- Robert Preidt



SOURCE: JAMA/Archives journals, news release, Dec. 8, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Start 2009 with The Chopra Centers Signature Self-Empowerment Workshop
2. PAHEF Works to Prevent Violence Against Women
3. Major Retailers Experience 161% Increase in Attempted Hacker Attacks, According to SecureWorks
4. Over-the-Phone Weight Loss Counseling Works
5. International workshop aims to boost public engagement work in developing countries
6. BET Networks Joins the International Call to Stop the Spread of HIV on World AIDS Day Monday, December 1 with a Special Episode of 106 & PARK Followed by BET News Exclusive ARE YOU POSITIVE?
7. HHS AIDS.gov to Use Blogs, Virtual Worlds, and Social Networks to Deliver HIV Information for World AIDS Day 2008
8. Agito Networks Names New CEO, Broadens Depth of Experience of Enterprise Mobility Leader
9. Message Archiving Leader Privacy Networks Announces Free Anti-Spam Software to Businesses and Organizations
10. Employers Want National Approach to Health Care—Still Believe Employer-Based System Works Best: New Survey Looks At Attitudes toward Health Care Reform and Major Health Care Issues.
11. Nurture(R) by Steelcase Wins Second Consecutive Nightingale Award for SYNC(TM) Caregiver Workspace Solution
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Half-Dose Flu Shot Works Well in Young Adults
(Date:6/25/2016)... ... ... of Bruton Memorial Library on June 21 due to a possible lice infestation, as reported ... head lice: the parasite’s ability to live away from a human host, and to infest ... in the event that lice have simply gotten out of control. , As lice are ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency ... named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a ... area —Johnson is one of the first doctors to perform the treatment. Orthobiologics ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Conventional wisdom preaches ... success. In terms of the latter, setting the bar too high can result in ... than just slow progress toward their goal. , Research from PsychTests.com ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... To deal with these feelings, many turn to unhealthy avenues, such as drug or ... Center of Marne, Michigan, has released tools for healthy coping following a traumatic event. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate ... in Latin America . ... ... ... ...
(Date:6/23/2016)... 23, 2016 The vast majority of dialysis ... facility.  Treatments are usually 3 times a week, with ... including travel time, equipment preparation and wait time.  This ... grueling for patients who are elderly and frail.  Many ... and rehabilitation centers for some duration of time. ...
(Date:6/23/2016)... June 23, 2016 The Biotechnology ... continues to present great opportunities to investors. Stock-Callers.com assesses ... Intrexon Corp. (NYSE: XON ), Vertex Pharmaceuticals ... (NASDAQ: ARNA ), and Regeneron Pharmaceuticals Inc. ... stocks and receive your complimentary trade alerts at: ...
Breaking Medicine Technology: