Navigation Links
Hair samples from infants show exposure to anti-HIV drugs in the womb and during breast-feeding
Date:7/21/2012

Researchers from the University of California, San Francisco (UCSF) and Makerere University in Uganda have used hair and blood samples from three-month old infants born to HIV-positive mothers to measure the uninfected babies' exposureboth in the womb and from breast-feedingto antiretroviral medications their mothers were taking. The results, they said, are surprising.

"We found high levels of exposure to three antiretroviral medications in the hair samples of HIV uninfected infants at twelve weeks of life," said study senior author, Monica Gandhi, MD, MPH, associate professor of medicine at the UCSF Division of HIV/AIDS at San Francisco General Hospital and Trauma Center (SFGH).

"From looking at plasma level data at the same time point, we believe that transfer of two of the medicines from mother to baby occurs exclusively in the womb and transfer of the third medication occurs both in the womb and through breastfeeding."

The findings could lead to new ways to protect infants from HIV transmission and to better understand the development of toxicities and resistance to the drugs, the researchers said.

A single plasma level of a medication reflects drug exposure over approximately 24 hours. Measuring the concentrations of antiretrovirals in a small hair sample reveals exposure over the past month. The team therefore measured both plasma and hair levels of medications in babies whose mothers were taking HIV medications to get a better idea of when drugs are being passed from mother to baby. "Since fetuses start growing hair in the womb, hair sampling gives us an opportunity to examine exposures to drug before birth," said Gandhi.

UCSF researchers have pioneered the use of hair sampling for measuring antiretroviral levels. The procedure is now a standard measure in many research studies, equivalent in HIV clinical care to measuring hemoglobin A1C to monitor average blood glucose levels in patients with diabetes.
'/>"/>

Contact: Jeff Sheehy
jsheehy@ari.ucsf.edu
415-597-8165
University of California - San Francisco
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. SomaLogic publishes proteomic biomarker analysis of lung cancer tissue samples
2. Depressed moms behavior may play role in infants sleep problems
3. Research shows efficacy of treatment model developed at Women & Infants
4. Low-Income Mothers May Overfeed Their Infants
5. Gut flora affects maturation of B cells in infants
6. Phthalates in PVC floors taken up by the body in infants
7. Disease that stunts infants growth traced to same gene that makes kids grow too fast
8. Infants cant distinguish between large and small groups
9. Women & Infants to participate in national effort to increase breastfeeding rates
10. Keep Infants Out of Sun and Heat, Experts Warn
11. Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hair samples from infants show exposure to anti-HIV drugs in the womb and during breast-feeding
(Date:8/4/2015)... ... August 04, 2015 , ... PerceptiMed, ... Richard Carmona, M.D., M.P.H., FACS, to its Board of Directors effective August 1, ... lives," Dr. Carmona said. "I strongly believe in the mission of the company ...
(Date:8/4/2015)... , ... August 04, 2015 , ... ... Local Food,” scheduled for Nov. 3 – 4, 2015, at UC San Diego, ... create new businesses, improve food access, and manage resources efficiently against the dueling ...
(Date:8/4/2015)... ... ... Many men are confused about the safety of testosterone replacement therapy. In ... voice of authority for men seeking accurate information about testosterone. , Renew Man™ ... in the safe and effective treatment of low testosterone. In recent years, the experts ...
(Date:8/4/2015)... ... August 04, 2015 , ... They say a picture is worth a thousand ... and medical art can be essential. StayWell, a health solutions company, announced today it ... solutions have been used by physicians and other health care providers for more than ...
(Date:8/4/2015)... ... August 04, 2015 , ... Discovia, a leading ... announced that John Munro, a 15-year veteran of the eDiscovery services industry, has ... , “I am thrilled to join Discovia at this important point in its ...
Breaking Medicine News(10 mins):Health News:Dr. Richard Carmona, 17th Surgeon General of the United States, Joins PerceptiMed, Inc.’s Board of Directors 2Health News:Dr. Richard Carmona, 17th Surgeon General of the United States, Joins PerceptiMed, Inc.’s Board of Directors 3Health News:Diversity of Urban and Hydroponic Farms of the Future to Highlight Seedstock Annual Conference Field Trip 2Health News:Diversity of Urban and Hydroponic Farms of the Future to Highlight Seedstock Annual Conference Field Trip 3Health News:New Video from Renew Man™ Raises Awareness of the Right Way to Correct Low Testosterone 2Health News:New Video from Renew Man™ Raises Awareness of the Right Way to Correct Low Testosterone 3Health News:StayWell Offers Instant Downloads, Licensing of Medical Art to Improve Patient Education 2Health News:StayWell Offers Instant Downloads, Licensing of Medical Art to Improve Patient Education 3Health News:John Munro Joins eDiscovery Leader Discovia as Vice President of Managed Services Operations 2Health News:John Munro Joins eDiscovery Leader Discovia as Vice President of Managed Services Operations 3
... the sentencing of actor Sylvester Stallone came as an anti-climax ... Sydney. ,He was fined $2,975 for bringing banned ... of $10,000. ,A Customs search of his luggage ... February last had revealed 48 vials of the banned human ...
... of those suffering from AIDS came forth as hundreds of ... there to support them, gathered at a candlelight memorial ... AIDS Candlelight Memorial Day late Sunday saw more than 500 ... wearing white T-shirts and holding a candles. The third Sunday ...
... American bio-pharmaceutical major Gilead, which has entered into generic ... its HIV drug Viread, is hoping to get a ... made considerable progress in implementing our access programme and ... a pricing of $1 a day for the pill," ...
... According to a new study, repeated exposure to one person's ... shared opinions from multiple people. , ,This ... recipients sense of familiarity and in some cases gives a ... then it actually is. , ,In a series ...
... is on in the US to rein in sexual offenders ... safer for everyone. ,Social networking sites allow users ... and let them send messages to one another and, in ... MySpace had initially balked when attorneys general from eight states ...
... in the Shangdong province of eastern China have been afflicted ... has since been contained, state news agency Xinhua has reported. ... and another 393 people mostly children were still ... agency said, citing Bao Wenhui, the deputy director of the ...
Cached Medicine News:Health News:Steroid Scam: Sylvester Stallone Gets Away With a Light Punishment 2Health News:AIDS Victims, Supporters Gather in Bond of Hope 2Health News:Gilead's AIDS Drug Awaits Patent in India 2Health News:Repetition Is Like Chanting The More It is Heard the More You Believe It 2Health News:My Space Pressured into Sharing Data on Sex Offenders 2
(Date:8/4/2015)... Md. , Aug. 4, 2015 ... drug-free over-the-counter ActiPatch® Musculoskeletal Pain Therapy medical devices, ... users of its ActiPatch 7-day trial device has ... journal Pain Management http://www.futuremedicine.com/doi/full/10.2217/PMT.15.35 .  ... the survey and submitted an assessment.  ...
(Date:8/4/2015)... 4, 2015 Research and Markets ( http://www.researchandmarkets.com/research/nl392k/alcohol ... Ethoxylate Market by Application (Household & Personal Care, Pharmaceutical, ... Forecasts to 2019" report to their offering. ... valued at $5,124.9 million in 2014 and is projected ... 2014 to 2019. The data mentioned in the report ...
(Date:8/4/2015)... Second Quarter 2015 Highlights: ... quarter of 2014 , Net earnings attributable to Team ... after adjustments , Diluted net earnings per share of ... 15.2% to $99.4 million 2015 Outlook: ... of 24.0% to 26.0%; Adjusted EBITDA margin remains between 10.5% ...
Breaking Medicine Technology:BioElectronics' Landmark 5,000+ Chronic Pain Patient Study Published in Pain Management Medical Journal 2Global Alcohol Ethoxylate Market 2015 - Market Trends, Forecasts to 2019 for the $5.1 Billion Industry 2Global Alcohol Ethoxylate Market 2015 - Market Trends, Forecasts to 2019 for the $5.1 Billion Industry 3Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 2Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 3Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 4Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 5Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 6Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 7Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 8Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 9Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 10Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 11Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 12Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 13Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 14Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 15Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 16Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 17Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 18Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 19Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 20Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 21Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 22Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 23Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 24Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 25Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 26Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 27Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 28Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 29Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 30Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 31Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 32Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 33
... Phase 2 Results of Perifosine in the Treatment of ... ... NEW YORK, June 2 Keryx Biopharmaceuticals,Inc. (Nasdaq: ... KRX-0401,(Perifosine) have been selected for both poster presentation and,publication ...
... June 2 Jazz,Pharmaceuticals, Inc. (Nasdaq: JAZZ ) ... Phase III pivotal clinical trials of JZP-6,(sodium oxybate) for ... this trial is a key milestone in the JZP-6,program. ... trial in the fourth,quarter of 2008," said Samuel Saks, ...
Cached Medicine Technology:Keryx Biopharmaceuticals, Inc. Announces Poster Presentation Highlighting Observed Clinical Activity of KRX-0401 (Perifosine) at the American Society of Clinical Oncology Meeting in Chicago, Illinois 2Keryx Biopharmaceuticals, Inc. Announces Poster Presentation Highlighting Observed Clinical Activity of KRX-0401 (Perifosine) at the American Society of Clinical Oncology Meeting in Chicago, Illinois 3Keryx Biopharmaceuticals, Inc. Announces Poster Presentation Highlighting Observed Clinical Activity of KRX-0401 (Perifosine) at the American Society of Clinical Oncology Meeting in Chicago, Illinois 4Keryx Biopharmaceuticals, Inc. Announces Poster Presentation Highlighting Observed Clinical Activity of KRX-0401 (Perifosine) at the American Society of Clinical Oncology Meeting in Chicago, Illinois 5Jazz Pharmaceuticals, Inc. Completes Enrollment in First of Two Phase III Clinical Trials of Sodium Oxybate to Treat Fibromyalgia 2Jazz Pharmaceuticals, Inc. Completes Enrollment in First of Two Phase III Clinical Trials of Sodium Oxybate to Treat Fibromyalgia 3
... centrifuge is designed especially for ... cover with safety interlock switch, ... emissions, "hold" position for continuous ... motor, maximum stability and compact, ...
... The Rotanta 460 family ... extraordinary line that meets ... demands. They feature high ... Their state-of-the-art technology and ...
The Spinchron 15 centrifuge provides all the versatility and high capacity needed for today's full-service clinical lab needs. This centrifuge is available in a nonrefrigerated model with a speed up ...
... lens handle lets them hold the ... itself. Lenses and tints are shown ... white with literature holders on each ... black, red, or white marble, gray ...
Medicine Products: