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HUMIRA(R) (adalimumab) Data Show That Treating Early Rheumatoid Arthritis With Combination Treatment Resulted in Cost Savings From Improved Work Productivity
Date:6/12/2008

approximately USD$6,086) per patient per

year.

-- Among paid workers only, indirect cost savings in patients treated with

HUMIRA plus MTX were attributed as follows:

o 79 percent to improved work performance;

o 12 percent to the patient's improved ability to gain or

retain employment;

o 9 percent to the reduced number of missed workdays.

In a separate analysis of the same study, researchers identified that in patients with early RA treated with HUMIRA plus MTX, baseline joint damage (assessed by joint space narrowing, joint space erosion and total sharp score, or TSS) is an independent predictor of a patient's ability to maintain or gain employment. TSS is a measure of joint damage progression. A smaller change in TSS reflects less progression of joint damage, with a positive score indicating worse radiographic damage. A total of 664 patients were included in this analysis, with average disease duration of eight months. Key findings included:

-- The likelihood of failing to gain or retain employment was

significantly associated with baseline joint damage (extent of joint

erosion and joint space narrowing), as measured by TSS at baseline

(p<0.0001), as well as poor scores on other measures evaluating

physical and mental well-being.

-- The number of missed work days and degree of work performance were not

associated with baseline joint damage.

-- Missing work due to early RA was significantly associated with scores

on the Health Assessment Questionnaire (HAQ), which evaluates the level

of pain and disability caused by RA (p<0.0001). Therefore, those with

better HAQ scores tended to miss less work.

-- Performance at work was also significantly associated with HAQ scores

(p<0.0001) in addition to other measures evaluating disease activity

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SOURCE Abbott
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