-- Among paid workers only, indirect cost savings in patients treated with
HUMIRA plus MTX were attributed as follows:
o 79 percent to improved work performance;
o 12 percent to the patient's improved ability to gain or
o 9 percent to the reduced number of missed workdays.
In a separate analysis of the same study, researchers identified that
in patients with early RA treated with HUMIRA plus MTX, baseline joint
damage (assessed by joint space narrowing, joint space erosion and total
sharp score, or TSS) is an independent predictor of a patient's ability to
maintain or gain employment. TSS is a measure of joint damage progression.
A smaller change in TSS reflects less progression of joint damage, with a
positive score indicating worse radiographic damage. A total of 664
patients were included in this analysis, with average disease duration of
eight months. Key findings included:
-- The likelihood of failing to gain or retain employment was
significantly associated with baseline joint damage (extent of joint
erosion and joint space narrowing), as measured by TSS at baseline
(p<0.0001), as well as poor scores on other measures evaluating
physical and mental well-being.
-- The number of missed work days and degree of work performance were not
associated with baseline joint damage.
-- Missing work due to early RA was significantly associated with scores
on the Health Assessment Questionnaire (HAQ), which evaluates the level
of pain and disability caused by RA (p<0.0001). Therefore, those with
better HAQ scores tended to miss less work.
-- Performance at work was also significantly associated with HAQ scores
(p<0.0001) in addition to other measures evaluating disease activity<
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