Navigation Links
HRT Ups Death Risk for Women With Lung Cancer
Date:5/30/2009

Shortened survival points to estrogen's potential role in the disease, experts say

SATURDAY, May 30 (HealthDay News) -- The current use of combined hormone replacement therapy (HRT) is associated with a higher risk of dying for women diagnosed with non-small cell lung cancer, a new study shows.

The risk was highest in current smokers, less high in former smokers and least high in women who never smoked, say researchers reporting Saturday at the annual meeting of the American Society of Clinical Oncology (ASCO), in Orlando, Fla.

"This is a major concern," said study lead author Dr. Rowan Chlebowski, a medical oncologist with the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center. "In current smokers, one in 100 experience avoidable death from non-small cell lung cancer. Women almost certainly shouldn't be using both combined hormone replacement therapy and tobacco at the same time," he said at a Saturday ASCO news briefing.

"We want to do everything we can to prevent lung cancer," added Dr. Jeffrey Crawford, chief of medical oncology at Duke Comprehensive Cancer Center in Durham, N.C. "But if you're a current or former smoker, in particular, this is another reason not to consider hormone replacement therapy."

According to Chlebowski, about 15 percent of postmenopausal women in the United States still take hormone therapy, although that is down from previous years.

The new results, based on data from the landmark Women's Health Initiative (WHI) trial, relate only to the combined estrogen-plus-progestin regimen of hormone therapy, not to the use of estrogen on its own.

The findings do appear to be another blow for hormone replacement therapy, which has already been associated with an elevated risk of heart attack, stroke and breast cancer.

This new findings were based a secondary analysis of data on more than 16,600 women participating in the Women's Health Initiative. Some of these women had taken combined hormone therapy -- conjugated equine estrogen (CEE) plus medroxyprogesterone acetate (MPA) -- while others had not.

Smoking rates were similar in the two groups. Half of the participants were never smokers, 40 percent were past smokers, and only 10 percent currently smoked.

The risk of developing lung cancer was similar in both groups, but women taking the hormones were 61 percent more likely to die of lung cancer than women in the placebo arm (67 women died in the hormone group vs. 39 of those taking a placebo).

Over a period of almost eight years of treatment and follow-up, 3.4 percent of smokers taking hormone therapy who also developed lung cancer died of the disease, compared to 2.3 percent of smokers who were diagnosed with the illness but did not take HRT, the study found.

"Median survival was 9.4 months versus 16.1 months in favor of the group that did not receive estrogen plus progestin," Chlebowski said.

The findings build on previous research that has hinted that estrogen might play a role in non-small cell lung cancer.

"Such a large trial helps to bring that information home and, especially in smokers, we know that there's an interaction between HRT, lung cancer and smoking from prior observational studies and pre-clinical studies," said Dr. Karen Reckamp, assistant professor of medicine at City of Hope Cancer Center in Duarte, Calif. "We see more and more non-smoking women getting lung cancer in general and often younger women. We know that there are estrogen receptors in the lung and in lung cancers and so there's definitely an interaction between the development of lung cancer and hormones."

More information

There's more on results from the Women's Health Initiative at the U.S. National Heart, Lung, and Blood Institute.



SOURCES: Jeffrey Crawford, M.D., chief, medical oncology, Duke Comprehensive Cancer Center, Durham, N.C.; Karen Reckamp, M.D., assistant professor of medicine, thoracic oncology division, City of Hope Cancer Center, Duarte, Calif.; May 30, 2009, American Society of Clinical Oncology news conference with Rowan Chlebowski, M.D., Ph.D., medical oncologist, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Anemia associated with greater risk of death in heart disease patients
2. U.S. Cancer Death Rates Continue to Fall
3. Fred A. Baughman Jr., MD Announces: Vets Sudden Cardiac Deaths Are Not Suicides or Overdoses
4. U.S. Swine Flu Death Toll Now at 5
5. Psychiatric Drugs Might Raise Cardiac Death Risk
6. Third U.S. Swine Flu Death Reported
7. Massive decline in rates of coronary death in Iceland are largely attributed to risk factor reductions in the population
8. GADA Points to Safety of FDA Approved Generics in Wake of Wellington Polo Horse Deaths from Compounded Drugs
9. Irregular Heartbeat During Angioplasty Could Raise Death Risk
10. Texas Officials Report 2nd Swine Flu Death in U.S.
11. Video: New Survey Finds 97 Percent of Women Understand Weight Increases Heart Disease Risk - The Leading Cause of Female Death in the United States - Yet 55 Percent Remain Overweight
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
HRT Ups Death Risk for Women With Lung Cancer
(Date:12/5/2016)... ... December 05, 2016 , ... Airy Jeanine is putting ... Songwriter-Producer Corey “Chorus” Gibson who has worked on hits by mega-artists like Rihanna, ... https://twitter.com/coreychorus , The sessions taking place in North Jersey’s Cybertime Studios ...
(Date:12/5/2016)... ... December 05, 2016 , ... As renowned, board-certified dermatologists, Dr. Sabrina G. Fabi ... patients who do not do their research and undergo cosmetic dermatology treatments from unqualified ... midst of a renaissance and every other month a new treatment or device is ...
(Date:12/5/2016)... Columbus, OH (PRWEB) , ... December 05, 2016 ... ... novel engineering solution called the CardioQuick Patch® significantly improves the reproducibility and accuracy ... usability in various healthcare settings. , Over the last 60 years, studies ...
(Date:12/4/2016)... , ... December 03, 2016 , ... While James Earl ... serving as host for in a show called "Front Page". One of the forthcoming ... years, breast cancer rates have plummeted in large part due to early detection. Like ...
(Date:12/4/2016)... ... December 04, 2016 , ... Patients who wish ... take advantage of a cosmetic procedure known as Carbon Dioxide (C02) Fractional ... appearance of age spots, fine lines, uneven coloration, wrinkles, scarring, skin laxity ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... Dec 2, 2016 Research and Markets has ... newsletter to their offering. ... , R&D Drug Pipeline ... proprietary R&D Drug Pipeline Database provides 24/7 online access to information ... the market and on investigational drug candidates in research & development. ...
(Date:12/2/2016)... -- bioLytical Laboratories, un líder mundial en test rápidos de enfermedades ... Test , a los miembros de la Kenya Pharmaceutical Association. ... ... HIV Self Test! (PRNewsFoto/bioLytical Laboratories) ... http://photos.prnewswire.com/prnh/20161201/444905 ) bioLytical fue invitada por la Clinton Health ...
(Date:12/2/2016)... SPRINGFIELD GARDENS, N.Y. , Dec. 2, 2016 /PRNewswire/ ... victims, will be included in the Emergency Response Training ... "We are very excited to have LifeVac become part ... Arthur Lih , Founder and CEO of LifeVac. "Having ... use LifeVac safely and effectively will help leverage our ...
Breaking Medicine Technology: