Navigation Links
HPV18 DNA levels are not prognostic for precancerous cervical lesions
Date:1/27/2009

Perhaps surprisingly, the number of copies of the carcinogenic human papillomavirus type 18 (HPV18) relative to cellular DNA is not associated with the likelihood of progression to advanced precancerous lesions of the cervix, according to a study in the January 27 online issue of the Journal of the National Cancer Institute.

Two types of HPV are most frequently associated with cervical cancer, HPV16 and HPV18. Previous studies showed that the number of HPV16 copies per cell correlated with an increasing risk of progression to cervical intraepithelial neoplasia grade 2 or 3 (CIN2-3). The prognostic significance of HPV18 DNA level is not known.

In the current study, Long Fu Xi, M.D, Ph.D., of the University of Washington in Seattle, and colleagues compared the number of copies of HPV18 DNA relative to cellular DNA at baseline with a woman's risk of progressing to CIN2-3. The 303 study participants were drawn from the Atypical Squamous Cells of Undetermined Significance and Low-Grade Squamous Intraepithelial Lesion Triage Study.

During the 2-year study period, 92 women were diagnosed with CIN2-3. Among women with a cytologic diagnosis of low- or high-grade squamous intraepithelial lesions at enrollment, HPV18 DNA level was lower in women with CIN2-3 than those without CIN2-3.

"In summary, our data indicated that HPV18 DNA levels were highest among women with evidence of a benign squamous intraepithelial lesion, intermediate among those with CIN2-3, and lowest among those with normal cytological findings," the authors write. "Thus, testing for high levels of HPV18 DNA does not appear to be clinically useful."

In an accompanying editorial, Eduardo Franco, Dr.P.H., and Franois Coutle, M.D., of McGill University in Montreal, agree with the authors' conclusion and applaud their effort to elucidate the underlying biology of cervical cancer. "As far as clinical practice is concerned, the obvious conclusion from the stu
'/>"/>

Contact: Caroline McNeil
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Study: Higher DHA Levels Improve Neurodevelopmental Outcomes in Premature Girls
2. Children with inflammatory bowel disease have surprisingly high folate levels, study finds
3. Children with Inflammatory Bowel Disease Have Surprisingly High Folate Levels, Study Finds
4. Women in Coastal Areas Have Higher Mercury Levels
5. Cholesterol Levels May Not Measure Cardiac Risk
6. Most heart attack patients cholesterol levels did not indicate cardiac risk
7. High insulin levels raise risk of breast cancer in postmenopausal women
8. Government at all Levels Will Continue to Spend on Essential Services and Invest in the Future, According to Onvia Study
9. Study Shows Fish Oils Dramatically Improve Cholesterol Levels in Professional Football Players
10. Low Levels of 2 Enzymes in Ovarian Cancer Cells Shortened Survival
11. Give Your Heart a Holiday: Eating Almonds Helps Support Healthy Fat Levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... FL (PRWEB) , ... July 30, 2015 , ... Using ... eradicate suicide and teach people more effective ways to prevent and manage major depression. ... to react fast enough, so people fall through the cracks and die needlessly everyday,” ...
(Date:7/30/2015)... Mequon, Wisconsin (PRWEB) , ... July 30, 2015 , ... ... rejuvenation. Kybella is a nonsurgical treatment designed specifically for the elimination ... is one of the first locations in the state of Wisconsin to offer this ...
(Date:7/30/2015)... ... July 30, 2015 , ... The Tisch ... Institute Designation , The Tisch Cancer Institute (TCI) at the Icahn School of ... center. TCI joins an elite group of 69 cancer institutions nationwide that have ...
(Date:7/30/2015)... ... July 30, 2015 , ... Author Dr. Raul Llanos seeks ... in his new self-help book, “ Consciously Healing our Webs of Health, Wellbeing, Success, ... message: “If we take responsibility for ourselves, we can create better realities.” His book ...
(Date:7/30/2015)... Washington, DC (PRWEB) , ... July 30, 2015 ... ... in a fight with its Medicare administrative contractor (MAC) over submitted claims for ... rejected. Calling it a challenge to program integrity, Becky Dennis, a nurse auditor ...
Breaking Medicine News(10 mins):Health News:Happiness Expert Develops Pioneering Online Tools for Sufferers of Major Depression, and Who may be Suicidal 2Health News:Happiness Expert Develops Pioneering Online Tools for Sufferers of Major Depression, and Who may be Suicidal 3Health News:Quintessa MedSpa Offers Nonsurgical Double-chin Elimination 2Health News:The Tisch Cancer Institute at Icahn School of Medicine at Mount Sinai Earns National Cancer Institute Designation 2Health News:The Tisch Cancer Institute at Icahn School of Medicine at Mount Sinai Earns National Cancer Institute Designation 3Health News:The Tisch Cancer Institute at Icahn School of Medicine at Mount Sinai Earns National Cancer Institute Designation 4Health News:The Tisch Cancer Institute at Icahn School of Medicine at Mount Sinai Earns National Cancer Institute Designation 5Health News:The Tisch Cancer Institute at Icahn School of Medicine at Mount Sinai Earns National Cancer Institute Designation 6Health News:New book by Dr. Raul Llanos: ‘The power to change is within’ 2Health News:New book by Dr. Raul Llanos: ‘The power to change is within’ 3Health News:Hospital Details Fight for Bariatric Surgery Reimbursement in AIS Newsletter 2Health News:Hospital Details Fight for Bariatric Surgery Reimbursement in AIS Newsletter 3
... Help Kids Worldwide, NEW YORK, Feb. 4 ... are being asked to submit creative,drawings for the 2008 ... One winner will be chosen from thousands of,entries and ... UNICEF,holiday greeting card, sold exclusively at Pier 1 Imports ...
... YORK, February 4, 2008 The Juvenile Diabetes ... of type 1 diabetes research, announced today that ... company based in Winston-Salem, N.C. that focuses on ... Through its Industry Discovery and Development Partnership Program, ...
... Feb. 4 Renowned esthetician, Karen,Dunlap, has developed ... recognized as the number-one most nutritious and powerful ... the dots between science and,nature, Dunlap discovered that ... -- magnifies its benefits. Her new signature facial, ...
... and 4 percent of former illicit drug users ... year following an organ transplant. These results are ... a journal by John Wiley & Sons. The ... ( http://www.interscience.wiley.com/journal/livertransplantation ). , Substance abuse can lead ...
... 2008 Contrary to previous research, older adults who use ... reduced risk of developing dementia or Alzheimers disease. This is ... the American Geriatrics Society that tracked patients using vitamin E ... than 5 years. The study also finds that the combined ...
... connecting patients and caregivers offers tips to families, ... ... helpful, CHICAGO, Feb. 4 What do you say, what ... or suffering from a serious,disease? To kick-off National Patient Recognition Week, ...
Cached Medicine News:Health News:Budding Young Artists Invited to Compete in 17th Annual Pier 1 Imports/UNICEF Greeting Card Contest 2Health News:Budding Young Artists Invited to Compete in 17th Annual Pier 1 Imports/UNICEF Greeting Card Contest 3Health News:JDRF partners with Plureon to explore generating insulin-producing cells from adult stem cells 2Health News:Breakthrough 'Acai Berry Anti-Aging Facial' Applies Benefits of Nature's Super-Food to the Skin 2Health News:Former substance abusers rarely relapse after organ transplantation 2Health News:Vitamin E or C does not reduce risk of dementia or Alzheimer's 2Health News:It's National Patient Recognition Week - Here's How You Can Do Something Special for Someone Facing Illness 2Health News:It's National Patient Recognition Week - Here's How You Can Do Something Special for Someone Facing Illness 3
(Date:7/29/2015)... Roche (SIX: RO, ROG; OTCQX: RHHBY) ... Mutation Test v2 for Premarket Approval (PMA) to ... a companion diagnostic test for AZD9291, an AstraZeneca ... with an acquired resistant mutation.  ... adenocarcinoma with tumor containing an EGFR sensitizing mutation ...
(Date:7/29/2015)... 2015 Dignity Health Saint Francis Memorial Hospital ... services of the hospital,s former Total Joint Center and ... expanding services to include shoulder orthopedic care. The new ... Memorial Hospital at 1199 Bush Street. ... aimed at providing a continuum of orthopedic care delivered ...
(Date:7/29/2015)... , July 29, 2015  Unilife Corporation ("Unilife" ... UNS), a developer, manufacturer and supplier of injectable drug ... financing strategy that provides the Company with flexibility and ... Unilife has signed an equity purchase agreement for ... LLC ("LPC"), a Chicago -based institutional ...
Breaking Medicine Technology:Roche submits filing to FDA for companion diagnostic for non-small cell lung cancer drug therapy 2Roche submits filing to FDA for companion diagnostic for non-small cell lung cancer drug therapy 3Saint Francis Memorial Hospital Orthopedic Institute Offers Comprehensive Orthopedic Care in One Location 2Unilife Announces Multifaceted Financing Strategy 2Unilife Announces Multifaceted Financing Strategy 3Unilife Announces Multifaceted Financing Strategy 4Unilife Announces Multifaceted Financing Strategy 5
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: