Navigation Links
HPV18 DNA levels are not prognostic for precancerous cervical lesions
Date:1/27/2009

Perhaps surprisingly, the number of copies of the carcinogenic human papillomavirus type 18 (HPV18) relative to cellular DNA is not associated with the likelihood of progression to advanced precancerous lesions of the cervix, according to a study in the January 27 online issue of the Journal of the National Cancer Institute.

Two types of HPV are most frequently associated with cervical cancer, HPV16 and HPV18. Previous studies showed that the number of HPV16 copies per cell correlated with an increasing risk of progression to cervical intraepithelial neoplasia grade 2 or 3 (CIN2-3). The prognostic significance of HPV18 DNA level is not known.

In the current study, Long Fu Xi, M.D, Ph.D., of the University of Washington in Seattle, and colleagues compared the number of copies of HPV18 DNA relative to cellular DNA at baseline with a woman's risk of progressing to CIN2-3. The 303 study participants were drawn from the Atypical Squamous Cells of Undetermined Significance and Low-Grade Squamous Intraepithelial Lesion Triage Study.

During the 2-year study period, 92 women were diagnosed with CIN2-3. Among women with a cytologic diagnosis of low- or high-grade squamous intraepithelial lesions at enrollment, HPV18 DNA level was lower in women with CIN2-3 than those without CIN2-3.

"In summary, our data indicated that HPV18 DNA levels were highest among women with evidence of a benign squamous intraepithelial lesion, intermediate among those with CIN2-3, and lowest among those with normal cytological findings," the authors write. "Thus, testing for high levels of HPV18 DNA does not appear to be clinically useful."

In an accompanying editorial, Eduardo Franco, Dr.P.H., and Franois Coutle, M.D., of McGill University in Montreal, agree with the authors' conclusion and applaud their effort to elucidate the underlying biology of cervical cancer. "As far as clinical practice is concerned, the obvious conclusion from the stu
'/>"/>

Contact: Caroline McNeil
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Study: Higher DHA Levels Improve Neurodevelopmental Outcomes in Premature Girls
2. Children with inflammatory bowel disease have surprisingly high folate levels, study finds
3. Children with Inflammatory Bowel Disease Have Surprisingly High Folate Levels, Study Finds
4. Women in Coastal Areas Have Higher Mercury Levels
5. Cholesterol Levels May Not Measure Cardiac Risk
6. Most heart attack patients cholesterol levels did not indicate cardiac risk
7. High insulin levels raise risk of breast cancer in postmenopausal women
8. Government at all Levels Will Continue to Spend on Essential Services and Invest in the Future, According to Onvia Study
9. Study Shows Fish Oils Dramatically Improve Cholesterol Levels in Professional Football Players
10. Low Levels of 2 Enzymes in Ovarian Cancer Cells Shortened Survival
11. Give Your Heart a Holiday: Eating Almonds Helps Support Healthy Fat Levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... Casinos in Australia have grown ... international and online casinos. Revenue is estimated to increase ... through 2014-15. Greater per capita gambling expenditure has assisted ... in discretionary income levels have also assisted revenue growth, ... such as casino gambling services. Revenue is estimated to ...
(Date:7/12/2014)... July 12, 2014 “After my mom’s stroke, she ... a stroke and loss the use of his left side. Eating ... a way to help people like them enjoy eating again,” said ... prototype for the PATRICIA CAROL HALL PLATE (P C H PLATE). ... a more ergonomic way to eat for individuals who suffer from ...
(Date:7/12/2014)... OH (PRWEB) July 12, 2014 Wright & ... against DePuy Orthopedics , Inc., a subsidiary of Johnson & ... he suffers chronic pain after receiving a metal-on-metal DePuy Pinnacle ... later to remove the artificial hip implant. The DePuy hip ... Court, Northern District of Texas (Case No. 3:14-cv-2427) where ...
(Date:7/12/2014)... July 12, 2014 Dubai is buzzing ... legend is heading to the UAE. The National ... will be in the UAE from 28-31 October to ... support of diabetes awareness. The event is being organized ... and event management company based in Dubai. The announcement ...
(Date:7/12/2014)... 12, 2014 Floor-grade instrument ... 4.1 out of 5. This above-average score represents ... underpinning buyer negotiation power over the three years ... Son, “during the period, surging demand for healthcare ... with new product development, have placed upward pressure ...
Breaking Medicine News(10 mins):Health News:Casinos in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Casinos in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:Casinos in Australia Industry Market Research Report Now Updated by IBISWorld 4Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 2Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 3Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 4Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 5Health News:Los Angeles Basketball Legend Headed to Dubai 2Health News:Los Angeles Basketball Legend Headed to Dubai 3Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 3Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 4
... successfully respond to drugs that combat the AIDS virus can ... level enjoyed by people without HIV, a study published ... sheds light on poorly understood conditions as to why some ... immune cells, others see a slower increase in these key ...
... unwanted baby girls have been drowned in milk, burned alive in ... these days it is much easier to kill them in the ... in a new book on how a traditional preference for sons ... ,India has only 927 females for every 1,000 males ...
... a gene variant that raises a childs risk of ... attributed to inflammation of the gastrointestinal tract . ... a German study that identified the same gene variant ... is a chronic and painful condition attributed to inflammation ...
... a 58-year-old Texan, went for a swim only to ... surgeries, he is still in danger of losing a ... is fighting necrotizing fasciitis, a tissue-destroying disease caused by ... marketing consultant also is suffering from multiple organ failure ...
... than a thousand prisoners has failed to solve the ... rehabilitation programmes, said the BMA today. ,The ... Ministry of Justices introduction of emergency measures designed to ... A key element of the Government strategy was an ...
... belief that male circumcision can reduce HIV infection rates ... will be told next week . ,David ... conference to be held in Sydney from July 22-25, ... in HIV prevention. ,"We always knew that ...
Cached Medicine News:Health News:HIV Drug Combo can Boost Immune Marker in Long-term Patients: Study 2Health News:New Book Gives Gruesome Account of India Girl Killings 2Health News:New Book Gives Gruesome Account of India Girl Killings 3Health News:Gene Variants for Crohn's Disease Identified 2Health News:Gene Variants for Crohn's Disease Identified 3Health News:Texan Battles Flesh-eating Bacteria Contracted While Swimming 2Health News:Prison Healthcare Continues to Fail Despite Emergency Measures, Warns BMA 2Health News:Male Circumcision can Cut HIV Infection, Studies Show 2
(Date:7/10/2014)... DIEGO , July 10, 2014  RESMED INC. (NYSE: ... its fourth quarter and fiscal year ended June 30, 2014 ... Stock Exchange market close. A press release with ResMed,s results ... the company will host a webcast to discuss operating results ... to begin at 1:30 p.m. US Pacific Time and the ...
(Date:7/10/2014)... July 10, 2014  Decision Resources Group finds ... disease (ID) specialists are willing to prescribe Durata,s ... for use as OPAT, approximately two-thirds of the ... to their hospital inpatients. However, our findings indicate ... are initiated on OPAT following hospital discharge, and ...
(Date:1/15/2014)... DALLAS , Jan. 15, 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com ... to its store . (Photo: ... consumption upgrade and policy support, China,s ... the years, with total market size rising from 3.28 ...
Breaking Medicine Technology:ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3
... Pharmacy Technician Certification Board (PTCB) certification ... Technician Workforce Coalition of the Triad continue to ... North Carolina,s evolving healthcare system. The ... local community colleges, was formed to address the ongoing ...
... UNION CITY, Calif., July 19, 2011 Abaxis, Inc. (NasdaqGS: ... has scheduled a conference call to discuss its financial results ... 30, 2011. The call will be at 4:15 p.m. ET ... results for the first quarter of fiscal year 2012 after ...
Cached Medicine Technology:The Pharmacy Technician Workforce Coalition of the Triad and PTCB Position Pharmacy Technicians for Employment 2The Pharmacy Technician Workforce Coalition of the Triad and PTCB Position Pharmacy Technicians for Employment 3Abaxis to Report First Quarter Fiscal Year 2012 Financial Results Thursday, July 28, 2011 2
... Nanopipetting System Genesis NPS based on the ... you to miniaturize your assays for high ... and direct dilutions., Furthermore it is ... including gene expression analysis, gene mapping, SNP ...
... is a reagent dispensing system designed to ... microplates. This dispenser can be equipped with ... orifice nozzle heads. Precise plate positioning and ... to a variety of plate types including ...
... Dispenses volumes down to 0.5ul for 384 ... less than 30 seconds per plate significantly ... user interface that provides one-button dispensing. It ... suspensions, beads, or cells, with high precision ...
... QFill2 is the ideal system for fast, accurate ... pressure driven, pinch valve controlled dispensing mechanism, ensures ... all of the components that come into contact ... clean, and autoclave. The unique compact design saves ...
Medicine Products: