Navigation Links
HPV18 DNA levels are not prognostic for precancerous cervical lesions
Date:1/27/2009

Perhaps surprisingly, the number of copies of the carcinogenic human papillomavirus type 18 (HPV18) relative to cellular DNA is not associated with the likelihood of progression to advanced precancerous lesions of the cervix, according to a study in the January 27 online issue of the Journal of the National Cancer Institute.

Two types of HPV are most frequently associated with cervical cancer, HPV16 and HPV18. Previous studies showed that the number of HPV16 copies per cell correlated with an increasing risk of progression to cervical intraepithelial neoplasia grade 2 or 3 (CIN2-3). The prognostic significance of HPV18 DNA level is not known.

In the current study, Long Fu Xi, M.D, Ph.D., of the University of Washington in Seattle, and colleagues compared the number of copies of HPV18 DNA relative to cellular DNA at baseline with a woman's risk of progressing to CIN2-3. The 303 study participants were drawn from the Atypical Squamous Cells of Undetermined Significance and Low-Grade Squamous Intraepithelial Lesion Triage Study.

During the 2-year study period, 92 women were diagnosed with CIN2-3. Among women with a cytologic diagnosis of low- or high-grade squamous intraepithelial lesions at enrollment, HPV18 DNA level was lower in women with CIN2-3 than those without CIN2-3.

"In summary, our data indicated that HPV18 DNA levels were highest among women with evidence of a benign squamous intraepithelial lesion, intermediate among those with CIN2-3, and lowest among those with normal cytological findings," the authors write. "Thus, testing for high levels of HPV18 DNA does not appear to be clinically useful."

In an accompanying editorial, Eduardo Franco, Dr.P.H., and Franois Coutle, M.D., of McGill University in Montreal, agree with the authors' conclusion and applaud their effort to elucidate the underlying biology of cervical cancer. "As far as clinical practice is concerned, the obvious conclusion from the stu
'/>"/>

Contact: Caroline McNeil
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Study: Higher DHA Levels Improve Neurodevelopmental Outcomes in Premature Girls
2. Children with inflammatory bowel disease have surprisingly high folate levels, study finds
3. Children with Inflammatory Bowel Disease Have Surprisingly High Folate Levels, Study Finds
4. Women in Coastal Areas Have Higher Mercury Levels
5. Cholesterol Levels May Not Measure Cardiac Risk
6. Most heart attack patients cholesterol levels did not indicate cardiac risk
7. High insulin levels raise risk of breast cancer in postmenopausal women
8. Government at all Levels Will Continue to Spend on Essential Services and Invest in the Future, According to Onvia Study
9. Study Shows Fish Oils Dramatically Improve Cholesterol Levels in Professional Football Players
10. Low Levels of 2 Enzymes in Ovarian Cancer Cells Shortened Survival
11. Give Your Heart a Holiday: Eating Almonds Helps Support Healthy Fat Levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... York, New York (PRWEB) July 30, 2014 ... from uncontrollable brain bleeding has filed a Xarelto lawsuit ... by the blood thinner, Bernstein Liebhard LLP reports. According ... Court for the District of Vermont on July 25th, ... days when he suffered an irreversible brain bleed that ...
(Date:7/30/2014)... 2014 Imprivata ® (NYSE: ... and secure communications solutions for the healthcare industry, ... the most widely selected single sign-on (SSO) solution ... electronic medical records (EMR) systems with a 51 ... percent in the last 12 months), according to ...
(Date:7/30/2014)... Visitors to our region recognize how special it ... protection. Bob Kiesendahl, one of the owners of Woodloch ... Conservancy for donations collected through participation in the Green ... fast, as visitors welcome the opportunity to invest in ... The Kiesendahl family has owned Woodloch Resort for multiple ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 Hamilton ... opening of its new Carmel office on July 30th. ... will finally be moving to the state-of-the-art suite, located ... and innovative space will allow for one-on-one patient comfort, ... surgery experience. , Dr. Hamilton’s new office-suite will ...
(Date:7/30/2014)... (HealthDay News) -- Some obese people have a genetic ... in their brains when they see food, researchers report. ... triggers feelings of pleasure and gratification at the sight ... designed to prevent overeating, the scientists suggested. More ... typically caused by a combination of overeating, a ...
Breaking Medicine News(10 mins):Health News:Xarelto Lawsuit Alleges Man’s Death from Uncontrollable Brain Bleeding Was Caused by Xarelto, Bernstein Liebhard LLP Reports 2Health News:Xarelto Lawsuit Alleges Man’s Death from Uncontrollable Brain Bleeding Was Caused by Xarelto, Bernstein Liebhard LLP Reports 3Health News:Imprivata Achieves 51 Percent Single Sign-on Market Share Amongst U.S. Hospitals Using McKesson Paragon or Horizon EMR Systems, According to HIMSS Analytics 2Health News:Pocono Mountain Resort Guests Contribute Over $8500 to Protect Land in 6 Short Months 2Health News:Hamilton Facial Plastic Surgery Opens New Carmel Office 2Health News:Gene Mutation May Make Food More Tempting 2
... Health Advocate Christy Turlington Burns will speak at the ... Health meeting at the AAP National Conference & Exhibition ... ET. Ms. Turlington Burns is the founder of Every ... to increase public awareness of and support for improved ...
... developed by the Centers for Disease Control and ... Pediatrics (AAP), will be launched at the 2011 ... Oct. 15-17. "Autism Case Training -- ... on the fundamental components of identifying, diagnosing, and ...
... New research presented this week highlights the ability ... investigate publicly available genomic data to assess biological ... prospective cancer biomarkers for further validation. The unique ... not possible by other methods, from the massive ...
... onset breast tenderness after starting combination hormone therapy may ... women who don,t experience breast tenderness, a study by ... One reason for this may be that their breasts ... was much more pronounced after initiation of estrogen and ...
... Il. -- MRI scanning could become a powerful new ... according to Loyola University Health System cardiologist Binh An ... MRI study of patients who had recently begun taking ... cholesterol drugs significantly reduced the amount of cholesterol in ...
... 14 (HealthDay News) -- One in six cellphones in Britain ... coli, likely because so many people don,t wash their hands ... The findings also suggest that many people lie about their ... of Hygiene & Tropical Medicine and Queen Mary, University of ...
Cached Medicine News:Health News:CDC to launch new autism curriculum at AAP national conference & exhibition 2Health News:Drug safety, efficacy, and potential new cancer biomarker predicted by NextBio 2Health News:Drug safety, efficacy, and potential new cancer biomarker predicted by NextBio 3Health News:Breast tenderness in women getting combo hormone therapy associated with increase in breast density 2Health News:Breast tenderness in women getting combo hormone therapy associated with increase in breast density 3Health News:MRIs could become powerful tools for monitoring cholesteral therapy 2Health News:1 in 6 Cellphones in Britain Contaminated With 'Fecal Matter' 2
(Date:7/30/2014)... ALEXANDRIA, Va. , July 30, 2014 /PRNewswire-USNewswire/ ... of Managed Care Pharmacy (AMCP) last evening expressed ... developed by the Joint Commission of Pharmacy Practitioners ... other member organizations over a two-year period to ... process for pharmacists.  "Pharmacists are ...
(Date:7/30/2014)... 30, 2014 PuraMed BioScience ® , ... over-the-counter (OTC) medicinal and healthcare products, announced today ... name along with the name,s red and yellow ... trademarked name MigraPure ®  going forward. The ... homeopathic, natural migraine pain reliever will be reintroduced ...
(Date:7/30/2014)... -- Research and Markets has announced the addition of ... report to their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... a lower CAGR in developed countries; however, it is expected to ... , India , and Brazil ... of the hematology analyzers and reagents market is driven by factors ...
Breaking Medicine Technology:AMCP Endorses JCPP "Pharmacists' Patient Care Process" 2PuraMed BioScience Rebrands its Natural Migraine Relief Medication, LipiGesic M 2PuraMed BioScience Rebrands its Natural Migraine Relief Medication, LipiGesic M 3Hematology Analyzers & Reagents Market - Forecasts to 2019 2
... 13, 3010 Amgen (Nasdaq: AMGN ) ... evaluating XGEVA™ (denosumab) versus placebo in 1,432 men with ... study, demonstrated that XGEVA significantly improved median bone metastasis-free ... p=0.03) compared to placebo (primary endpoint), and significantly improved ...
... Fla., Dec. 13, 2010 The creators of the innovative Pill ... toys and a much needed medication management system to pediatric ... at Broward General, in Fort Lauderdale, Florida. ... will be onsite Wednesday, December 15, from 1-3 pm distributing ...
Cached Medicine Technology:XGEVA™ (Denosumab) Significantly Improved Bone Metastasis-Free Survival in Men With Prostate Cancer 2XGEVA™ (Denosumab) Significantly Improved Bone Metastasis-Free Survival in Men With Prostate Cancer 3XGEVA™ (Denosumab) Significantly Improved Bone Metastasis-Free Survival in Men With Prostate Cancer 4XGEVA™ (Denosumab) Significantly Improved Bone Metastasis-Free Survival in Men With Prostate Cancer 5XGEVA™ (Denosumab) Significantly Improved Bone Metastasis-Free Survival in Men With Prostate Cancer 6XGEVA™ (Denosumab) Significantly Improved Bone Metastasis-Free Survival in Men With Prostate Cancer 7Med Time Technology, Inc. Teams up with Give A Smile, Inc. to Provide Pill Timer™ Kits and Toys to Children and Parents at the Chris Evert Children's Hospital of Broward General 2
Inquire...
... with low electroendosmosis (EEO) ... DNA/RNA applications. If separated ... be used as substrates ... and restriction endonucleases, a ...
... NuSieve 3:1 Agarose is a molecular biology grade, ... for fine resolution of small DNA, RNA, and ... enhance the speed of gel processing and blotting. ... resolution of DNA fragments up to 1,000 bp, ...
... With a very high gel ... exclusion limit, Certified megabase agarose is ... FIGE applications. The gels remain easy ... as 0.3% and allow shorter run ...
Medicine Products: